2024
Noise-aware dynamic image denoising and positron range correction for Rubidium-82 cardiac PET imaging via self-supervision
Xie H, Guo L, Velo A, Liu Z, Liu Q, Guo X, Zhou B, Chen X, Tsai Y, Miao T, Xia M, Liu Y, Armstrong I, Wang G, Carson R, Sinusas A, Liu C. Noise-aware dynamic image denoising and positron range correction for Rubidium-82 cardiac PET imaging via self-supervision. Medical Image Analysis 2024, 100: 103391. PMID: 39579623, DOI: 10.1016/j.media.2024.103391.Peer-Reviewed Original ResearchImage denoisingPositron range correctionDynamic framesSelf-supervised methodsSuperior visual qualityLow signal-to-noise ratioCardiac PET imagingDenoising methodSignal-to-noise ratioSelf-supervisionVisual qualityHigh-energy positronsRange correctionsDenoisingNoise levelImage spatial resolutionImage qualityDefect contrastPET imagingImage quantificationRadioactive isotopesPatient scansQuantitative accuracyImagesFrameNew Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease. Journal Of Nuclear Cardiology 2024, 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionDose-aware Diffusion Model for 3D Low-count Cardiac SPECT Image Denoising with Projection-domain Consistency
Xie H, Gan W, Chen X, Zhou B, Liu Q, Xia M, Guo X, Liu Y, An H, Kamilov U, Wang G, Sinusas A, Liu C. Dose-aware Diffusion Model for 3D Low-count Cardiac SPECT Image Denoising with Projection-domain Consistency. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10655170.Peer-Reviewed Original ResearchImage denoisingImage denoising performanceDeep learning techniquesNoise-levelDenoising performanceDenoising resultsNeural networkLearning techniquesSPECT imagesLow count levelsSPECT scansDenoisingSampling stepIterative reconstructionNoise amplitudeImagesInjected dosePatient studiesDiffusion modelRadiation exposureCardiology studiesSPECTNetworkStochastic natureMLEMExperimental Evaluation of DE-SPECT: A Hyperspectral SPECT System for Region-Selective 3-D Gamma-Ray Spectroscopy of Molecular Theragnostics
Jin Y, Zannoni E, Sankar P, Gura D, Wu R, Zhu S, Zhang F, Streicher M, Yang H, He Z, Metzler S, Liu C, Sinusas A, Meng L. Experimental Evaluation of DE-SPECT: A Hyperspectral SPECT System for Region-Selective 3-D Gamma-Ray Spectroscopy of Molecular Theragnostics. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10657212.Peer-Reviewed Original ResearchCadmium zinc tellurideCadmium zinc telluride detectorsGamma-ray spectroscopyHigh-sensitivity imagingUniform phantomResolution phantomSPECT systemZinc telluridePhantom studyImage qualityPhantomImaging capabilitiesImaging performanceAperture systemFOVMultiple radiotracersHigh-resolutionCollimatorDual-field-of-viewPeripheral vascular diseaseDetectorState-of-the-art technologiesTellurideClinical systemsCoordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging
Jeng G, Chen P, Hsieh M, Liu Z, Langdon J, Ahn S, Staib L, Stendahl J, Thorn S, Sinusas A, Duncan J, O'Donnell M. Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging. IEEE Transactions On Biomedical Engineering 2024, 71: 3312-3323. PMID: 38941195, DOI: 10.1109/tbme.2024.3420220.Peer-Reviewed Original ResearchPrincipal stretchesAxial displacement componentsSpeckle tracking methodSpeckle tracking approachTracking methodRobust filterDisplacement componentsTissue incompressibilityDisplacement estimationStrain componentsDisplacement gradientsStrain informationLocalized diseased regionStrain imagingLagrangian strainLeast-squares methodTracking approachTracking frameworkCoordinate systemCardiac coordinate systemProbe orientationFilterHigher spatial resolutionCardiac datasetsEnhanced accuracyHeteroscedastic Uncertainty Estimation Framework for Unsupervised Registration
Zhang X, Pak D, Ahn S, Li X, You C, Staib L, Sinusas A, Wong A, Duncan J. Heteroscedastic Uncertainty Estimation Framework for Unsupervised Registration. Lecture Notes In Computer Science 2024, 15002: 651-661. DOI: 10.1007/978-3-031-72069-7_61.Peer-Reviewed Original ResearchUnsupervised registrationReal-world medical imagesCollaborative training strategyMedical image datasetsDeep learning methodsAccurate displacement estimationSignal-to-noise ratioImage datasetsRegistration architectureLearning methodsMedical imagesTraining strategyNoise distributionUncertainty estimationWeighting schemeRegistration performanceSpatial domainEstimation frameworkInput-dependentUncertainty estimation frameworkUniform noise levelsDisplacement estimationFrameworkNoise levelUnsupervisedThe Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).
Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0). Journal Of Nuclear Medicine 2024, 65: 1795-1801. PMID: 39362762, PMCID: PMC11533915, DOI: 10.2967/jnumed.124.268292.Peer-Reviewed Original ResearchCoronary artery calciumCT attenuation correction imagesStress total perfusion deficitMyocardial perfusion imagingTotal perfusion deficitAttenuation correction imagesPerfusion imagingREFINE SPECTImprove prediction of adverse outcomesPerfusion deficitsSPECT myocardial perfusion imagingIncreased risk of MACEPredictive of adverse outcomesMedian follow-upInvasive coronary angiographyRisk of MACEAdverse cardiovascular eventsCAC scoreExperience MACECoronary angiographyArtery calciumInternational registryCardiovascular eventsFollow-upClinical dataAdaptive Correspondence Scoring for Unsupervised Medical Image Registration
Zhang X, Stendahl J, Staib L, Sinusas A, Wong A, Duncan J. Adaptive Correspondence Scoring for Unsupervised Medical Image Registration. Lecture Notes In Computer Science 2024, 15096: 76-92. DOI: 10.1007/978-3-031-72920-1_5.Peer-Reviewed Original ResearchMedical image registrationAdaptation frameworkMedical image datasetsUnsupervised learning schemeAdaptive training schemeImage registrationError residualsSupervision signalsLearning schemeImage datasetsRegistration architectureIntensity constancyScore mapNoisy gradientsMedical imagesTraining schemeImage reconstructionPerformance degradationLambertian assumptionCorrespondence scoresLoss of correspondenceTraining objectivesDisplacement estimationImage acquisitionSchemeMYOCARDIAL ISCHEMIC BURDEN IN PATIENTS WITH PERIPHERAL ARTERY DISEASE UNDERGOING MYOCARDIAL PERFUSION IMAGING
Wang K, Shanbhag A, Sharir T, Hauser M, Dorbala S, Di Carli M, Fish M, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Halcox J, Dey D, Berman D, Miller R, Slomka P. MYOCARDIAL ISCHEMIC BURDEN IN PATIENTS WITH PERIPHERAL ARTERY DISEASE UNDERGOING MYOCARDIAL PERFUSION IMAGING. Canadian Journal Of Cardiology 2024, 40: s120-s121. DOI: 10.1016/j.cjca.2024.08.182.Peer-Reviewed Original ResearchRISK STRATIFICATION WITH PRE-OPERATIVE MYOCARDIAL PERFUSION IMAGING
Kim D, Builoff V, Sharir T, Hauser M, Dorbala S, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Dey D, Berman D, Miller R, Slomka P, Fish M. RISK STRATIFICATION WITH PRE-OPERATIVE MYOCARDIAL PERFUSION IMAGING. Canadian Journal Of Cardiology 2024, 40: s122. DOI: 10.1016/j.cjca.2024.08.185.Peer-Reviewed Original ResearchAssociation between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-cause mortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlationDuDoCFNet: Dual-Domain Coarse-to-Fine Progressive Network for Simultaneous Denoising, Limited-View Reconstruction, and Attenuation Correction of Cardiac SPECT
Chen X, Zhou B, Guo X, Xie H, Liu Q, Duncan J, Sinusas A, Liu C. DuDoCFNet: Dual-Domain Coarse-to-Fine Progressive Network for Simultaneous Denoising, Limited-View Reconstruction, and Attenuation Correction of Cardiac SPECT. IEEE Transactions On Medical Imaging 2024, 43: 3110-3125. PMID: 38578853, PMCID: PMC11539864, DOI: 10.1109/tmi.2024.3385650.Peer-Reviewed Original ResearchMulti-task learning methodCross-domainLimited-viewLearning methodsCoarse-to-fine estimationProgressive networkDual domainCross-modal feature fusionDual-domain networkProgressive learning strategyCross-modal informationSimultaneous denoisingFeature fusionSingle-photon emission computed tomographyImage domainCardiac single-photon emission computed tomographyReconstruction accuracyDenoisingHardware expenseFusion mechanismAccelerated scansImage noiseM-mapSuperior accuracyNetworkEvolution of cardiac amyloidosis imaging with bone-avid tracers: From qualification to quantification
Malhotra S, Sinusas A. Evolution of cardiac amyloidosis imaging with bone-avid tracers: From qualification to quantification. Journal Of Nuclear Cardiology 2024, 39: 102032. PMID: 39214278, DOI: 10.1016/j.nuclcard.2024.102032.Peer-Reviewed Original ResearchContrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study
Feizi A, DiRito J, Richfield O, Stendahl J, Harris M, Spindler S, Edwards C, Lysyy T, Lee S, Boutagy N, Feher A, Yoo P, Hosgood S, Mulligan D, Nicholson M, Sinusas A, Haakinson D, Tietjen G. Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study. Artificial Organs 2024, 48: 1536-1548. PMID: 39189738, DOI: 10.1111/aor.14840.Peer-Reviewed Original ResearchContrast-enhanced computed tomographyNormothermic perfusionComputed tomographyHuman kidneyLocal informationAnalysis of biopsiesAssess organ functionNovel therapeutic strategiesEx vivo assessmentWhole organ perfusionProof-of-concept studyEx vivo perfusionInfusion scansAnatomical structuresOrgan perfusionThe Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT
Miller R, Lemley M, Shanbhag A, Bednarski B, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT. Journal Of Nuclear Cardiology 2024, 38: 101926. DOI: 10.1016/j.nuclcard.2024.101926.Peer-Reviewed Original ResearchMolecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease
Jang S, Thorn S, Zohora F, Porcaro O, Burns R, Vermillion B, Callegari S, Guerrera N, DePino A, Liu C, Luna-Gutierrez M, Ferro-Flores G, Sinusas A. Molecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease. Journal Of Nuclear Cardiology 2024, 38: 101997. DOI: 10.1016/j.nuclcard.2024.101997.Peer-Reviewed Original ResearchHybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner
Thorn S, Burns R, Zohora F, Jang S, Porcaro O, Guerrera N, DePino A, Vermillion B, Liu C, Luna-Gutiérrez M, Ferro-Flores G, Sinusas A. Hybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner. Journal Of Nuclear Cardiology 2024, 38: 101972. DOI: 10.1016/j.nuclcard.2024.101972.Peer-Reviewed Original ResearchDevelopment Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve.
Vermillion B, Jang S, Alashi A, Burns R, Guerrera N, Depino A, Martins S, Papademetris X, Zeiss C, Guo L, Liu C, Thorn S, Sinusas A. Development Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve. Journal Of Cardiovascular Computed Tomography 2024, 18: s50-s51. DOI: 10.1016/j.jcct.2024.05.117.Peer-Reviewed Original ResearchNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original ResearchEarly Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition
Zohora F, Lee S, Lin A, Jang S, Vermillion B, Burns R, Callegari S, DePino A, Guerrera N, Thorn S, Sinusas A. Early Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition. Journal Of Cardiovascular Computed Tomography 2024, 18: s25-s26. DOI: 10.1016/j.jcct.2024.05.058.Peer-Reviewed Original Research