A Yale-developed drug shows promise as immune therapy for cancer
A therapy developed by Yale Cancer Center researchers stimulates immune cells to shrink or kill tumors in mice, according to a new study published in the Journal of Experimental Medicine. The therapy is effective alone or in combination with existing cancer immunotherapies, and it appears to have lasting effects, the researchers said.
Study Explores Role of Metabolism in Immune Cell Behavior
What makes healthy cells change and become dysfunctional to the point of causing disease? In addition to a disruption in genes that regulate cells, there is another factor in cell misbehavior that involves metabolism, say Yale researchers.
Iwasaki Is Honored by the International Cytokine & Interferon Society
Akiko Iwasaki, PhD, Waldemar Von Zedtwitz Profesor of Immunobiology and Molecular, Cellular, and Developmental Biology; and professor of dermatology, is a 2019 recipient of the Seymour & Vivian Milstein Award for Excellence in Interferon and Cytokine Research, given by the International Cytokine & Interferon Society (ICIS).
CORES: Utilizing New Approaches
Several of YSM’s core research facilities utilize state-of-the-art technologies to generate data that shed light on human diseases. YCCI helps support these facilities and the underlying informatics resources and expertise necessary to manage and analyze the data they generate.
Research in the news: Yale study identifies new target for severe asthma, chronic inflammatory diseases
Platelets, the colorless blood cells responsible for clotting, play a critical role in controlling inflammation, but their effect on the immune system is less clear. A new Yale-led study has identified a protein from platelets — Dkk-1 — that contributes to chronic inflammation and has also revealed the role of platelets in the immune response.
Yale researchers find new pathway underlying multiple myeloma relapse
One of the biggest questions about the treatment of multiple myeloma, a form of blood cancer, is why nearly all patients treated with current therapies eventually suffer relapse. A Yale Cancer Center study may have solved this mystery by identifying how cancer cells escape treatment, leading to recurrence. The findings were presented Dec. 6 at the 57th annual meeting of the American Hematologic Society in Orlando, Florida.
Yale Cancer Center receives $11 million from National Cancer Institute for lung cancer research
Armed with an $11 million grant from the National Cancer Institute (NCI), Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven will launch a new research program in non-small cell lung cancer, one of the world’s most prevalent and lethal forms of cancer.
Study reveals new way to ‘rewire’ immune cells to slow tumor growth
Inside a tumor, immune cells and cancer cells battle for survival. The advantage may go to the cells that metabolize the most glucose, say Yale researchers who have identified a new way to boost immune response by metabolically “rewiring” immune cells.
INSIGHT-Pfizer, Bristol revive cancer drugs that rev up immune system
Some of the most heralded new cancer drugs fight the disease by removing brakes on the immune system. Now a few leading drugmakers are paying attention to a second, opposing force: medicines that accelerate the immune system's attack.
Research in the news: Suppressing the immune response may lead to more potent vaccines, a study finds
Yale researchers uncovered a new role for a type of immune cell, known as regulatory T cells, in promoting long-term immunity. The new insight gets researchers one step closer to developing vaccines that could be more protective against some of the most intractable viral infections, including HIV and flu.
Spotlight on Clinical Research: May is Lupus Awareness Month
Lupus is a lifelong chronic disease in which the body’s immune system attacks healthy cells and tissue. This can cause damage to skin, joints, kidneys and other organs throughout the body. Anyone can get lupus, but it most often affects women and is also more common in women of African American, Hispanic and Asian descent.
Research in the news: Inflammatory immune cells can flip the genetic script
A type of immune cell that promotes inflammation during the immune response, TH17, can convert into another type of cell that reduces inflammation, Yale researchers have found. The finding, published April 29 in Nature, points to a possible therapeutic strategy for inflammation-mediated diseases, such as inflammatory bowel disease, multiple sclerosis, and rheumatoid arthritis.