Study Explores Role of Metabolism in Immune Cell Behavior
What makes healthy cells change and become dysfunctional to the point of causing disease? In addition to a disruption in genes that regulate cells, there is another factor in cell misbehavior that involves metabolism, say Yale researchers.
Study points to potential personalized approach to treating lupus
In individuals with lupus, immune cells attack the body’s own tissue and organs as if they are enemy invaders. A new Yale-led study describes how a protein found in common bacteria triggers that auto-immune response. The finding opens the door to future therapies targeting the bacteria rather than the immune system, the researchers said.
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
CaSB@Yale launches with $9.5M federal grant to battle deadliest cancers
Yale University researchers across a spectrum of disciplines are coming together to fight some of the deadliest forms of cancer with a novel approach that has gained support from the National Cancer Institute (NCI) of the National Institutes of Health (NIH).
Scientists find many gene 'drivers' of cancer, but warn: Don't ignore 'passengers'
A massive analysis of the entire genomes of 2,658 people with 38 different types of cancer has identified mutations in 179 genes and gene regulators as “drivers” — variations in DNA sequences that lead to the development of cancer.
In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
Colón-Ramos named McConnell Duberg Associate Professor
Daniel A. Colón-Ramos, PhD, recently appointed as Dorys McConnell Duberg Associate Professor of Neuroscience and Cell Biology, focuses his research on how synapses are formed and maintained to control behavior and store memories. Colón-Ramos’ discoveries have altered long-held views on the process and may offer important clues in the fight against disease.
Protein-slaying Drugs Could Be the Next Blockbuster Therapies
A drug strategy called targeted protein degradation; and pursued by Craig Crews, PhD, Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology, and professor of chemistry; capitalizes on the cell’s natural system for clearing unwanted or damaged proteins, and is in line to be used in promising clinical trials.Source: Nature
Of Worms and a Special Love of Home
Daniel Colón-Ramos works with the roundworm C. elegans as a means of advancing knowledge of the fundamental building blocks of the nervous system, saying that mastering the basics is essential to answering the bigger questions. He also has dedicated himself to improving opportunities for people in his native Puerto Rico.Source: Medicine@Yale