Schatz to Receive Paul Ehrlich and Ludwig Darmstaedter Prize
Immunologists David G. Schatz of Yale School of Medicine and Frederick W. Alt of Harvard Medical School are to receive the 2023 Paul Ehrlich and Ludwig Darmstaedter Prize. The two researchers are being acknowledged for their discovery of molecules and mechanisms that enable our immune system to perform the astounding feat of recognizing billions of different antigens on first contact.Source: YaleNews
Nasal Approach to COVID Vaccination Gains Traction
A Yale research team led by Akiko Iwasaki, PhD, has found success in a new approach to vaccination—systemic vaccines that train the entire body’s immune response followed by boosters administered directly to the nasal cavity, to deliver special protection in the part of the body most affected by SARS-CoV-2 infection.
Bob Saget died of head injury after falling, autopsy says. Here’s what to know about head trauma.
Given that comedian Bob Saget died of a severe head injury, experts - including Yale School of Medicine Neurology Chair David Hafler, MD - gave expert advice on the exact nature of severe head trauma, risk factors for severe injury, tips for prevention, and actionable steps for seeking medical help.Source: The Washington Post
Scientists Apply High-resolution, Single-cell Profiling to Understand Immune Response in Severe COVID-19
A new study by Yale researchers provides a single-cell resolution profile of the inflammatory severe COVID-19 disease, and the loss of coordination between the innate and adaptive immune response. This loss of coordination has the potential to amplify a person’s immune response to COVID-19, delaying viral clearance.
Nasal Vaccine May Aid Fight Against New Viral Variants
Akiko Iwasaki and her colleagues found that intranasal vaccination provided broad-based protection against heterologous respiratory viruses in mice, while so-called systemic immunization, which uses an injection to elicit body-wide protection, did not.Source: YaleNews
Rare Disorder Offers Roadmap for Understanding Roots of Inflammatory Disease
Yale researchers have discovered the underlying genetic cause of a rare childhood disorder that mimics inflammatory bowel disease, a finding that may help researchers uncover the roots of a host of other inflammatory and autoimmune disorders.Source: YaleNews
Rogue Antibodies Wreak Havoc in Severe COVID-19 Cases
These autoantibodies target and react with a person’s tissues or organs similar to ones that cause autoimmune diseases such as lupus or rheumatoid arthritis. In COVID-19 cases they can attack healthy tissue in brain, blood vessels, platelets, liver, and the gastrointestinal tract, researchers report.Source: YaleNews