Immune Sensing of Allergens Promotes Avoidance Behavior
A new study published in Nature demonstrates how the immune system plays a role in the development of behaviors to avoid food allergens. Previous research has suggested that the immune system may be involved in behavioral modification beyond simply protecting the body from infectious diseases.
Yale researchers are working on a whole new type of vaccine, targeting the insects that carry pathogens
A group of Yale researchers is working on a new kind of vaccine they believe could change the world: instead of acting against a pathogen, the vaccine would reduce the risk of transmission for mosquito-and-tick-borne illnesses by targeting the insects themselves.Source: Stamford Advocate
Nasal Vaccination May Protect Against Respiratory Viruses Better Than Injected Vaccines
Akiko Iwasaki, PhD, discusses her lab's finding that intranasal vaccinations, by triggering immune properties of mucosal membranes, may offer better protection against respiratory viruses than injected vaccines.
Nasal Vaccine May Aid Fight Against New Viral Variants
Akiko Iwasaki and her colleagues found that intranasal vaccination provided broad-based protection against heterologous respiratory viruses in mice, while so-called systemic immunization, which uses an injection to elicit body-wide protection, did not.Source: YaleNews
Sex-specific Immune Response in COVID-19 Linked to Cellular Metabolism
Researchers studying COVID-19 patients have found a metabolic pathway that is highly correlated with immune responses only in male patients, a group known to be more likely to suffer severe cases and die of the disease, representing a potential target for therapeutic intervention.Source: Yale News
Rogue Antibodies Wreak Havoc in Severe COVID-19 Cases
These autoantibodies target and react with a person’s tissues or organs similar to ones that cause autoimmune diseases such as lupus or rheumatoid arthritis. In COVID-19 cases they can attack healthy tissue in brain, blood vessels, platelets, liver, and the gastrointestinal tract, researchers report.Source: YaleNews
Scientists Unravel Mystery of Sex Disparities in COVID-19 Outcomes
"Age and sex are where immunological changes intersect,” says Akiko Iwasaki, PhD. Over the past year, Iwasaki and her colleagues from around the globe have compiled a rich literature of research that reveals in detail these and other factors that make the virus more lethal for men.Source: YaleNews
Understanding Immune System Blunders in Response to the Coronavirus
Genetics, gender, and even botched timing on the part of the immune response all appear important in the development of COVID-19. Akiko Iwasaki, PhD, is leading research to help us better predict who is likely to sail through a bout with COVID-19 and who may need targeted lifesaving care.