2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis
Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metabolism 2019, 30: 1024-1039.e6. PMID: 31735593, PMCID: PMC6944439, DOI: 10.1016/j.cmet.2019.10.006.Peer-Reviewed Original ResearchConceptsAge-associated B cellsFat-associated lymphoid clustersB cellsAdipose tissue leukocytesB-cell depletionB cell accumulationBody temperature maintenanceFALC formationVisceral adiposityCell depletionNLRP3 inflammasomeFemale miceLymphoid clustersMetabolic dysfunctionIL-1Metabolic impairmentIL-1RTissue leukocytesCell accumulationMetabolic homeostasisUnique populationLipolysisCellsTemperature maintenanceAdiposityAGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS
Camell C, Dixit V. AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS. Innovation In Aging 2019, 3: s106-s106. PMCID: PMC6845598, DOI: 10.1093/geroni/igz038.397.Peer-Reviewed Original ResearchFat-associated lymphoid clustersTissue B cellsB cell expansionAdipose tissueB cellsNLRP3 inflammasomeAdipose tissue immune cellsVisceral white adipose tissueB cell profileB-cell depletionB cell accumulationTissue immune cellsVisceral adipose tissueWhite adipose tissueAged B cellsFALC formationVisceral adiposityCell depletionInduces NLRP3Aged miceImmune cellsInsulin sensitivityFemale miceLymphoid clustersMetabolic dysfunctionBone Marrow: An Immunometabolic Refuge during Energy Depletion
Goldberg EL, Dixit VD. Bone Marrow: An Immunometabolic Refuge during Energy Depletion. Cell Metabolism 2019, 30: 621-623. PMID: 31577929, DOI: 10.1016/j.cmet.2019.08.022.Peer-Reviewed Original Research
2015
Adipose tissue as an immunological organ
Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity 2015, 23: 512-518. PMID: 25612251, PMCID: PMC4340740, DOI: 10.1002/oby.21003.Peer-Reviewed Original ResearchConceptsAdipose tissueImmunological organActive immunological organNumerous immune cellsObesity-associated comorbiditiesImmune cell subtypesAdaptive immune responsesType 2 diabetesCertain infectious diseasesWhole-body metabolismMetabolic syndromeObese subjectsChronic inflammationImmunological aspectsInsulin resistanceTissue inflammationObesity influencesImmune cellsImmune surveillanceT cellsImmune responseTissue leukocytosisPubMed searchB cellsHost defense