2020
Pan-cancer analysis of whole genomes
Aaltonen L, Abascal F, Abeshouse A, Aburatani H, Adams D, Agrawal N, Ahn K, Ahn S, Aikata H, Akbani R, Akdemir K, Al-Ahmadie H, Al-Sedairy T, Al-Shahrour F, Alawi M, Albert M, Aldape K, Alexandrov L, Ally A, Alsop K, Alvarez E, Amary F, Amin S, Aminou B, Ammerpohl O, Anderson M, Ang Y, Antonello D, Anur P, Aparicio S, Appelbaum E, Arai Y, Aretz A, Arihiro K, Ariizumi S, Armenia J, Arnould L, Asa S, Assenov Y, Atwal G, Aukema S, Auman J, Aure M, Awadalla P, Aymerich M, Bader G, Baez-Ortega A, Bailey M, Bailey P, Balasundaram M, Balu S, Bandopadhayay P, Banks R, Barbi S, Barbour A, Barenboim J, Barnholtz-Sloan J, Barr H, Barrera E, Bartlett J, Bartolome J, Bassi C, Bathe O, Baumhoer D, Bavi P, Baylin S, Bazant W, Beardsmore D, Beck T, Behjati S, Behren A, Niu B, Bell C, Beltran S, Benz C, Berchuck A, Bergmann A, Bergstrom E, Berman B, Berney D, Bernhart S, Beroukhim R, Berrios M, Bersani S, Bertl J, Betancourt M, Bhandari V, Bhosle S, Biankin A, Bieg M, Bigner D, Binder H, Birney E, Birrer M, Biswas N, Bjerkehagen B, Bodenheimer T, Boice L, Bonizzato G, De Bono J, Boot A, Bootwalla M, Borg A, Borkhardt A, Boroevich K, Borozan I, Borst C, Bosenberg M, Bosio M, Boultwood J, Bourque G, Boutros P, Bova G, Bowen D, Bowlby R, Bowtell D, Boyault S, Boyce R, Boyd J, Brazma A, Brennan P, Brewer D, Brinkman A, Bristow R, Broaddus R, Brock J, Brock M, Broeks A, Brooks A, Brooks D, Brors B, Brunak S, Bruxner T, Bruzos A, Buchanan A, Buchhalter I, Buchholz C, Bullman S, Burke H, Burkhardt B, Burns K, Busanovich J, Bustamante C, Butler A, Butte A, Byrne N, Børresen-Dale A, Caesar-Johnson S, Cafferkey A, Cahill D, Calabrese C, Caldas C, Calvo F, Camacho N, Campbell P, Campo E, Cantù C, Cao S, Carey T, Carlevaro-Fita J, Carlsen R, Cataldo I, Cazzola M, Cebon J, Cerfolio R, Chadwick D, Chakravarty D, Chalmers D, Chan C, Chan K, Chan-Seng-Yue M, Chandan V, Chang D, Chanock S, Chantrill L, Chateigner A, Chatterjee N, Chayama K, Chen H, Chen J, Chen K, Chen Y, Chen Z, Cherniack A, Chien J, Chiew Y, Chin S, Cho J, Cho S, Choi J, Choi W, Chomienne C, Chong Z, Choo S, Chou A, Christ A, Christie E, Chuah E, Cibulskis C, Cibulskis K, Cingarlini S, Clapham P, Claviez A, Cleary S, Cloonan N, Cmero M, Collins C, Connor A, Cooke S, Cooper C, Cope L, Corbo V, Cordes M, Cordner S, Cortés-Ciriano I, Covington K, Cowin P, Craft B, Craft D, Creighton C, Cun Y, Curley E, Cutcutache I, Czajka K, Czerniak B, Dagg R, Danilova L, Davi M, Davidson N, Davies H, Davis I, Davis-Dusenbery B, Dawson K, De La Vega F, De Paoli-Iseppi R, Defreitas T, Dei Tos A, Delaneau O, Demchok J, Demeulemeester J, Demidov G, Demircioğlu D, Dennis N, Denroche R, Dentro S, Desai N, Deshpande V, Deshwar A, Desmedt C, Deu-Pons J, Dhalla N, Dhani N, Dhingra P, Dhir R, DiBiase A, Diamanti K, Ding L, Ding S, Dinh H, Dirix L, Doddapaneni H, Donmez N, Dow M, Drapkin R, Drechsel O, Drews R, Serge S, Dudderidge T, Dueso-Barroso A, Dunford A, Dunn M, Dursi L, Duthie F, Dutton-Regester K, Eagles J, Easton D, Edmonds S, Edwards P, Edwards S, Eeles R, Ehinger A, Eils J, Eils R, El-Naggar A, Eldridge M, Ellrott K, Erkek S, Escaramis G, Espiritu S, Estivill X, Etemadmoghadam D, Eyfjord J, Faltas B, Fan D, Fan Y, Faquin W, Farcas C, Fassan M, Fatima A, Favero F, Fayzullaev N, Felau I, Fereday S, Ferguson M, Ferretti V, Feuerbach L, Field M, Fink J, Finocchiaro G, Fisher C, Fittall M, Fitzgerald A, Fitzgerald R, Flanagan A, Fleshner N, Flicek P, Foekens J, Fong K, Fonseca N, Foster C, Fox N, Fraser M, Frazer S, Frenkel-Morgenstern M, Friedman W, Frigola J, Fronick C, Fujimoto A, Fujita M, Fukayama M, Fulton L, Fulton R, Furuta M, Futreal P, Füllgrabe A, Gabriel S, Gallinger S, Gambacorti-Passerini C, Gao J, Gao S, Garraway L, Garred Ø, Garrison E, Garsed D, Gehlenborg N, Gelpi J, George J, Gerhard D, Gerhauser C, Gershenwald J, Gerstein M, Gerstung M, Getz G, Ghori M, Ghossein R, Giama N, Gibbs R, Gibson B, Gill A, Gill P, Giri D, Glodzik D, Gnanapragasam V, Goebler M, Goldman M, Gomez C, Gonzalez S, Gonzalez-Perez A, Gordenin D, Gossage J, Gotoh K, Govindan R, Grabau D, Graham J, Grant R, Green A, Green E, Greger L, Grehan N, Grimaldi S, Grimmond S, Grossman R, Grundhoff A, Gundem G, Guo Q, Gupta M, Gupta S, Gut I, Gut M, Göke J, Ha G, Haake A, Haan D, Haas S, Haase K, Haber J, Habermann N, Hach F, Haider S, Hama N, Hamdy F, Hamilton A, Hamilton M, Han L, Hanna G, Hansmann M, Haradhvala N, Harismendy O, Harliwong I, Harmanci A, Harrington E, Hasegawa T, Haussler D, Hawkins S, Hayami S, Hayashi S, Hayes D, Hayes S, Hayward N, Hazell S, He Y, Heath A, Heath S, Hedley D, Hegde A, Heiman D, Heinold M, Heins Z, Heisler L, Hellstrom-Lindberg E, Helmy M, Heo S, Hepperla A, Heredia-Genestar J, Herrmann C, Hersey P, Hess J, Hilmarsdottir H, Hinton J, Hirano S, Hiraoka N, Hoadley K, Hobolth A, Hodzic E, Hoell J, Hoffmann S, Hofmann O, Holbrook A, Holik A, Hollingsworth M, Holmes O, Holt R, Hong C, Hong E, Hong J, Hooijer G, Hornshøj H, Hosoda F, Hou Y, Hovestadt V, Howat W, Hoyle A, Hruban R, Hu J, Hu T, Hua X, Huang K, Huang M, Huang M, Huang V, Huang Y, Huber W, Hudson T, Hummel M, Hung J, Huntsman D, Hupp T, Huse J, Huska M, Hutter B, Hutter C, Hübschmann D, Iacobuzio-Donahue C, Imbusch C, Imielinski M, Imoto S, Isaacs W, Isaev K, Ishikawa S, Iskar M, Islam S, Ittmann M, Ivkovic S, Izarzugaza J, Jacquemier J, Jakrot V, Jamieson N, Jang G, Jang J, Jayaseelan J, Jayasinghe R, Jefferys S, Jegalian K, Jennings J, Jeon S, Jerman L, Ji Y, Jiao W, Johansson P, Johns A, Johns J, Johnson R, Johnson T, Jolly C, Joly Y, Jonasson J, Jones C, Jones D, Jones D, Jones N, Jones S, Jonkers J, Ju Y, Juhl H, Jung J, Juul M, Juul R, Juul S, Jäger N, Kabbe R, Kahles A, Kahraman A, Kaiser V, Kakavand H, Kalimuthu S, von Kalle C, Kang K, Karaszi K, Karlan B, Karlić R, Karsch D, Kasaian K, Kassahn K, Katai H, Kato M, Katoh H, Kawakami Y, Kay J, Kazakoff S, Kazanov M, Keays M, Kebebew E, Kefford R, Kellis M, Kench J, Kennedy C, Kerssemakers J, Khoo D, Khoo V, Khuntikeo N, Khurana E, Kilpinen H, Kim H, Kim H, Kim H, Kim H, Kim J, Kim J, Kim J, Kim Y, King T, Klapper W, Kleinheinz K, Klimczak L, Knappskog S, Kneba M, Knoppers B, Koh Y, Komorowski J, Komura D, Komura M, Kong G, Kool M, Korbel J, Korchina V, Korshunov A, Koscher M, Koster R, Kote-Jarai Z, Koures A, Kovacevic M, Kremeyer B, Kretzmer H, Kreuz M, Krishnamurthy S, Kube D, Kumar K, Kumar P, Kumar S, Kumar Y, Kundra R, Kübler K, Küppers R, Lagergren J, Lai P, Laird P, Lakhani S, Lalansingh C, Lalonde E, Lamaze F, Lambert A, Lander E, Landgraf P, Landoni L, Langerød A, Lanzós A, Larsimont D, Larsson E, Lathrop M, Lau L, Lawerenz C, Lawlor R, Lawrence M, Lazar A, Lazic A, Le X, Lee D, Lee D, Lee E, Lee H, Lee J, Lee J, Lee J, Lee M, Lee-Six H, Lehmann K, Lehrach H, Lenze D, Leonard C, Leongamornlert D, Leshchiner I, Letourneau L, Letunic I, Levine D, Lewis L, Ley T, Li C, Li C, Li H, Li J, Li L, Li S, Li S, Li X, Li X, Li X, Li Y, Liang H, Liang S, Lichter P, Lin P, Lin Z, Linehan W, Lingjærde O, Liu D, Liu E, Liu F, Liu F, Liu J, Liu X, Livingstone J, Livitz D, Livni N, Lochovsky L, Loeffler M, Long G, Lopez-Guillermo A, Lou S, Louis D, Lovat L, Lu Y, Lu Y, Lu Y, Luchini C, Lungu I, Luo X, Luxton H, Lynch A, Lype L, López C, López-Otín C, Z. E, Ma Y, MacGrogan G, MacRae S, Macintyre G, Madsen T, Maejima K, Mafficini A, Maglinte D, Maitra A, Majumder P, Malcovati L, Malikic S, Malleo G, Mann G, Mantovani-Löffler L, Marchal K, Marchegiani G, Mardis E, Margolin A, Marin M, Markowetz F, Markowski J, Marks J, Marques-Bonet T, Marra M, Marsden L, Martens J, Martin S, Martin-Subero J, Martincorena I, Martinez-Fundichely A, Maruvka Y, Mashl R, Massie C, Matthew T, Matthews L, Mayer E, Mayes S, Mayo M, Mbabaali F, McCune K, McDermott U, McGillivray P, McLellan M, McPherson J, McPherson J, McPherson T, Meier S, Meng A, Meng S, Menzies A, Merrett N, Merson S, Meyerson M, Meyerson W, Mieczkowski P, Mihaiescu G, Mijalkovic S, Mikkelsen T, Milella M, Mileshkin L, Miller C, Miller D, Miller J, Mills G, Milovanovic A, Minner S, Miotto M, Arnau G, Mirabello L, Mitchell C, Mitchell T, Miyano S, Miyoshi N, Mizuno S, Molnár-Gábor F, Moore M, Moore R, Morganella S, Morris Q, Morrison C, Mose L, Moser C, Muiños F, Mularoni L, Mungall A, Mungall K, Musgrove E, Mustonen V, Mutch D, Muyas F, Muzny D, Muñoz A, Myers J, Myklebost O, Möller P, Nagae G, Nagrial A, Nahal-Bose H, Nakagama H, Nakagawa H, Nakamura H, Nakamura T, Nakano K, Nandi T, Nangalia J, Nastic M, Navarro A, Navarro F, Neal D, Nettekoven G, Newell F, Newhouse S, Newton Y, Ng A, Ng A, Nicholson J, Nicol D, Nie Y, Nielsen G, Nielsen M, Nik-Zainal S, Noble M, Nones K, Northcott P, Notta F, O’Connor B, O’Donnell P, O’Donovan M, O’Meara S, O’Neill B, O’Neill J, Ocana D, Ochoa A, Oesper L, Ogden C, Ohdan H, Ohi K, Ohno-Machado L, Oien K, Ojesina A, Ojima H, Okusaka T, Omberg L, Ong C, Ossowski S, Ott G, Ouellette B, P’ng C, Paczkowska M, Paiella S, Pairojkul C, Pajic M, Pan-Hammarström Q, Papaemmanuil E, Papatheodorou I, Paramasivam N, Park J, Park J, Park K, Park K, Park P, Parker J, Parsons S, Pass H, Pasternack D, Pastore A, Patch A, Pauporté I, Pea A, Pearson J, Pedamallu C, Pedersen J, Pederzoli P, Peifer M, Pennell N, Perou C, Perry M, Petersen G, Peto M, Petrelli N, Petryszak R, Pfister S, Phillips M, Pich O, Pickett H, Pihl T, Pillay N, Pinder S, Pinese M, Pinho A, Pitkänen E, Pivot X, Piñeiro-Yáñez E, Planko L, Plass C, Polak P, Pons T, Popescu I, Potapova O, Prasad A, Preston S, Prinz M, Pritchard A, Prokopec S, Provenzano E, Puente X, Puig S, Puiggròs M, Pulido-Tamayo S, Pupo G, Purdie C, Quinn M, Rabionet R, Rader J, Radlwimmer B, Radovic P, Raeder B, Raine K, Ramakrishna M, Ramakrishnan K, Ramalingam S, Raphael B, Rathmell W, Rausch T, Reifenberger G, Reimand J, Reis-Filho J, Reuter V, Reyes-Salazar I, Reyna M, Reynolds S, Rheinbay E, Riazalhosseini Y, Richardson A, Richter J, Ringel M, Ringnér M, Rino Y, Rippe K, Roach J, Roberts L, Roberts N, Roberts S, Robertson A, Robertson A, Rodriguez J, Rodriguez-Martin B, Rodríguez-González F, Roehrl M, Rohde M, Rokutan H, Romieu G, Rooman I, Roques T, Rosebrock D, Rosenberg M, Rosenstiel P, Rosenwald A, Rowe E, Royo R, Rozen S, Rubanova Y, Rubin M, Rubio-Perez C, Rudneva V, Rusev B, Ruzzenente A, Rätsch G, Sabarinathan R, Sabelnykova V, Sadeghi S, Sahinalp S, Saini N, Saito-Adachi M, Saksena G, Salcedo A, Salgado R, Salichos L, Sallari R, Saller C, Salvia R, Sam M, Samra J, Sanchez-Vega F, Sander C, Sanders G, Sarin R, Sarrafi I, Sasaki-Oku A, Sauer T, Sauter G, Saw R, Scardoni M, Scarlett C, Scarpa A, Scelo G, Schadendorf D, Schein J, Schilhabel M, Schlesner M, Schlomm T, Schmidt H, Schramm S, Schreiber S, Schultz N, Schumacher S, Schwarz R, Scolyer R, Scott D, Scully R, Seethala R, Segre A, Selander I, Semple C, Senbabaoglu Y, Sengupta S, Sereni E, Serra S, Sgroi D, Shackleton M, Shah N, Shahabi S, Shang C, Shang P, Shapira O, Shelton T, Shen C, Shen H, Shepherd R, Shi R, Shi Y, Shiah Y, Shibata T, Shih J, Shimizu E, Shimizu K, Shin S, Shiraishi Y, Shmaya T, Shmulevich I, Shorser S, Short C, Shrestha R, Shringarpure S, Shriver C, Shuai S, Sidiropoulos N, Siebert R, Sieuwerts A, Sieverling L, Signoretti S, Sikora K, Simbolo M, Simon R, Simons J, Simpson J, Simpson P, Singer S, Sinnott-Armstrong N, Sipahimalani P, Skelly T, Smid M, Smith J, Smith-McCune K, Socci N, Sofia H, Soloway M, Song L, Sood A, Sothi S, Sotiriou C, Soulette C, Span P, Spellman P, Sperandio N, Spillane A, Spiro O, Spring J, Staaf J, Stadler P, Staib P, Stark S, Stebbings L, Stefánsson Ó, Stegle O, Stein L, Stenhouse A, Stewart C, Stilgenbauer S, Stobbe M, Stratton M, Stretch J, Struck A, Stuart J, Stunnenberg H, Su H, Su X, Sun R, Sungalee S, Susak H, Suzuki A, Sweep F, Szczepanowski M, Sültmann H, Yugawa T, Tam A, Tamborero D, Tan B, Tan D, Tan P, Tanaka H, Taniguchi H, Tanskanen T, Tarabichi M, Tarnuzzer R, Tarpey P, Taschuk M, Tatsuno K, Tavaré S, Taylor D, Taylor-Weiner A, Teague J, Teh B, Tembe V, Temes J, Thai K, Thayer S, Thiessen N, Thomas G, Thomas S, Thompson A, Thompson A, Thompson J, Thompson R, Thorne H, Thorne L, Thorogood A, Tiao G, Tijanic N, Timms L, Tirabosco R, Tojo M, Tommasi S, Toon C, Toprak U, Torrents D, Tortora G, Tost J, Totoki Y, Townend D, Traficante N, Treilleux I, Trotta J, Trümper L, Tsao M, Tsunoda T, Tubio J, Tucker O, Turkington R, Turner D, Tutt A, Ueno M, Ueno N, Umbricht C, Umer H, Underwood T, Urban L, Urushidate T, Ushiku T, Uusküla-Reimand L, Valencia A, Van Den Berg D, Van Laere S, Van Loo P, Van Meir E, Van den Eynden G, Van der Kwast T, Vasudev N, Vazquez M, Vedururu R, Veluvolu U, Vembu S, Verbeke L, Vermeulen P, Verrill C, Viari A, Vicente D, Vicentini C, VijayRaghavan K, Viksna J, Vilain R, Villasante I, Vincent-Salomon A, Visakorpi T, Voet D, Vyas P, Vázquez-García I, Waddell N, Waddell N, Wadelius C, Wadi L, Wagener R, Wala J, Wang J, Wang J, Wang L, Wang Q, Wang W, Wang Y, Wang Z, Waring P, Warnatz H, Warrell J, Warren A, Waszak S, Wedge D, Weichenhan D, Weinberger P, Weinstein J, Weischenfeldt J, Weisenberger D, Welch I, Wendl M, Werner J, Whalley J, Wheeler D, Whitaker H, Wigle D, Wilkerson M, Williams A, Wilmott J, Wilson G, Wilson J, Wilson R, Winterhoff B, Wintersinger J, Wiznerowicz M, Wolf S, Wong B, Wong T, Wong W, Woo Y, Wood S, Wouters B, Wright A, Wright D, Wright M, Wu C, Wu D, Wu G, Wu J, Wu K, Wu Y, Wu Z, Xi L, Xia T, Xiang Q, Xiao X, Xing R, Xiong H, Xu Q, Xu Y, Xue H, Yachida S, Yakneen S, Yamaguchi R, Yamaguchi T, Yamamoto M, Yamamoto S, Yamaue H, Yang F, Yang H, Yang J, Yang L, Yang L, Yang S, Yang T, Yang Y, Yao X, Yaspo M, Yates L, Yau C, Ye C, Ye K, Yellapantula V, Yoon C, Yoon S, Yousif F, Yu J, Yu K, Yu W, Yu Y, Yuan K, Yuan Y, Yuen D, Yung C, Zaikova O, Zamora J, Zapatka M, Zenklusen J, Zenz T, Zeps N, Zhang C, Zhang F, Zhang H, Zhang H, Zhang H, Zhang J, Zhang J, Zhang J, Zhang X, Zhang X, Zhang Y, Zhang Z, Zhao Z, Zheng L, Zheng X, Zhou W, Zhou Y, Zhu B, Zhu H, Zhu J, Zhu S, Zou L, Zou X, deFazio A, van As N, van Deurzen C, van de Vijver M, Veer L, von Mering C. Pan-cancer analysis of whole genomes. Nature 2020, 578: 82-93. PMID: 32025007, PMCID: PMC7025898, DOI: 10.1038/s41586-020-1969-6.Peer-Reviewed Original ResearchMeSH KeywordsCell ProliferationCellular SenescenceChromothripsisCloud ComputingDNA Mutational AnalysisEvolution, MolecularFemaleGenome, HumanGenomicsGerm-Line MutationHigh-Throughput Nucleotide SequencingHumansInformation DisseminationMaleMutagenesisMutationNeoplasmsOncogenesPromoter Regions, GeneticReproducibility of ResultsRNA SplicingTelomeraseTelomereConceptsPan-Cancer Analysis of Whole GenomesInternational Cancer Genome ConsortiumPan-cancer analysisPan-Cancer Analysis of Whole Genomes ConsortiumStructural variantsNon-coding genomic elementsPoint mutationsAnalysis of Whole GenomesSomatic mutationsNon-coding mutationsRare germline variantsAbnormal telomere maintenanceConsequences of somatic mutationsPattern of somatic mutationsSignatures of mutational processesCancer driver discoveryCancer-associated genesSomatic point mutationsGenomic elementsWhole genomeLow replicative activitySmall insertionsCancer Genome ConsortiumBase substitutionsCancer genomes
2016
DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR
Micevic G, Muthusamy V, Damsky W, Theodosakis N, Liu X, Meeth K, Wingrove E, Santhanakrishnan M, Bosenberg M. DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR. Cell Reports 2016, 14: 2180-2192. PMID: 26923591, PMCID: PMC4785087, DOI: 10.1016/j.celrep.2016.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell Line, TumorCell ProliferationDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDown-RegulationGene Expression Regulation, NeoplasticHumansMechanistic Target of Rapamycin Complex 2Melanoma, ExperimentalMice, 129 StrainMice, Inbred C57BLMice, NudeMicroRNAsMultiprotein ComplexesNeoplasm TransplantationProportional Hazards ModelsRapamycin-Insensitive Companion of mTOR ProteinRNA InterferenceSkin NeoplasmsTOR Serine-Threonine KinasesTumor BurdenConceptsMelanoma formationPotential therapeutic targetMiR-196b expressionMouse melanoma modelPro-tumorigenic roleMTORC2 component RictorMelanoma growthTherapeutic targetMelanoma modelLoss of RictorHuman melanomaCancer typesTumor cellsMelanomaSpecific signaling pathwaysMTORC2 signalingSignaling pathwaysTurn preventsMiR-196b promoterDNA methyltransferase DNMT3BRictorControlling LevelsDNMT3BMethyltransferase DNMT3BCancer
2015
mTORC1 Activation Blocks Braf V600E -Induced Growth Arrest but Is Insufficient for Melanoma Formation
Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. mTORC1 Activation Blocks Braf V600E -Induced Growth Arrest but Is Insufficient for Melanoma Formation. Cancer Cell 2015, 27: 41-56. PMID: 25584893, PMCID: PMC4295062, DOI: 10.1016/j.ccell.2014.11.014.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p16HumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MelanocytesMelanoma, ExperimentalMiceMicroRNAsMolecular Sequence DataMultiprotein ComplexesMutationNevusProtein Serine-Threonine KinasesProto-Oncogene Proteins B-rafSignal TransductionSkin NeoplasmsTOR Serine-Threonine KinasesConceptsMelanoma formationGrowth arrestStable growth arrestMTORC2/AktSTK11 lossCDKN2A lossAkt activationIGF1R signalingMice resultsActivationArrestMTORC2Nevus developmentMTORC1/2SignalingAktMelanocytic nevus developmentMelanomagenesisMTORProgressionCDKN2AMelanocytesInactivationUpregulationComplete progression
2009
BrafV600E cooperates with Pten loss to induce metastatic melanoma
Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky Jr W, You MJ, DePinho RA, McMahon M, Bosenberg M. BrafV600E cooperates with Pten loss to induce metastatic melanoma. Nature Genetics 2009, 41: 544-552. PMID: 19282848, PMCID: PMC2705918, DOI: 10.1038/ng.356.Peer-Reviewed Original Research
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