Carrie L Lucas, PhD

Assistant Professor of Immunobiology

Research Interests

Immunologic Deficiency Syndromes; Immunoproliferative Disorders; Phosphatidylinositols; Protein Processing, Post-Translational; T-Lymphocytes; Signal Transduction

Research Organizations

Immunobiology: Human and Translational Immunology Program

Yale Cancer Center: Cancer Immunology

Research Summary

The Lucas laboratory uses human genomics, cellular and molecular biology, and signal transduction analyses to investigate lymphocytes of the immune system. Our studies begin with patients suffering from inherited immune disorders and utilize various approaches to uncover the genetic and biochemical defects responsible for disease with the goal of applying this knowledge not only to devise targeted therapies for rare disorders but also to more generally dissect basic pathways critical for adaptive immunity. We aim to identify novel signaling pathways using unbiased approaches including not only genomics but also phosphoproteomics with mass spectrometry to address questions related to human T cell biology (e.g., regulation of TCR-induced cell death, terminal differentiation, telomere length and cellular senescence/DNA damage responses). A major current focus of the lab is on phosphoinositide 3-kinase (PI3K) signaling and mechanisms of disease in patients with inherited mutations in PI3K subunits.

Selected Publications

Full List of PubMed Publications

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Contact Info

Carrie L Lucas, PhD
Mailing Address
Immunobiology300 George Street
3rd Floor, 353G

New Haven, CT 06511

Lucas Lab website