2024
Selective utilization of glucose metabolism guides mammalian gastrulation
Cao D, Bergmann J, Zhong L, Hemalatha A, Dingare C, Jensen T, Cox A, Greco V, Steventon B, Sozen B. Selective utilization of glucose metabolism guides mammalian gastrulation. Nature 2024, 634: 919-928. PMID: 39415005, PMCID: PMC11499262, DOI: 10.1038/s41586-024-08044-1.Peer-Reviewed Original ResearchConceptsCellular metabolismMammalian gastrulationHexosamine biosynthetic pathwayTranscription factor networksCellular signaling pathwaysSignaling morphogensGlucose metabolismCellular programmeBiosynthetic pathwayFate acquisitionCell fateHousekeeping natureGenetic mechanismsMesoderm migrationFactor networksERK activationExpression patternsSignaling pathwayDevelopmental processesStem cell modelCell typesSpecialized functionsDevelopmental contextMammalian embryosMouse embryos
2023
A genome-wide single-cell 3D genome atlas of lung cancer progression.
Liu M, Jin S, Agabiti SS, Jensen TB, Yang T, Radda JSD, Ruiz CF, Baldissera G, Muzumdar MD, Wang S. A genome-wide single-cell 3D genome atlas of lung cancer progression. BioRxiv 2023 PMID: 37546882, DOI: 10.1101/2023.07.23.550157.Peer-Reviewed Original ResearchHigh-content image-based CRISPR screening reveals regulators of 3D genome architectures
Yang B, Hu M, Jensen T, Radda J, Cheng Y, Jin S, Wang S. High-content image-based CRISPR screening reveals regulators of 3D genome architectures. Biophysical Journal 2023, 122: 306a. DOI: 10.1016/j.bpj.2022.11.1723.Peer-Reviewed Original Research
2021
Lung injury in axolotl salamanders induces an organ‐wide proliferation response
Jensen TB, Giunta P, Schultz NG, Griffiths JM, Duerr TJ, Kyeremateng Y, Wong H, Adesina A, Monaghan JR. Lung injury in axolotl salamanders induces an organ‐wide proliferation response. Developmental Dynamics 2021, 250: 866-879. PMID: 33587313, DOI: 10.1002/dvdy.315.Peer-Reviewed Original ResearchConceptsLung regenerationLung massX cranial nervesLung injurySupplemental administrationCranial nervesProliferative responseProliferation responseInjury responseLungInjuryMultiple cell typesMesenchymal cellsNeuregulinAmputationMost tissuesPneumocytesProliferationCell typesResponseAxolotl salamanderCellsNerve
2020
Transcriptional Heterogeneity of Neural Stem Cells during Axolotl Salamander Spinal Cord Regeneration
Monaghan J, Jensen T, Stein D, Mun E, Maden M. Transcriptional Heterogeneity of Neural Stem Cells during Axolotl Salamander Spinal Cord Regeneration. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00360.Peer-Reviewed Original ResearchNeural stem cellsNascent RNA productionRepressive chromatin marksGlobal RNA synthesisProbe setsCell typesGlobal changeHippo-YAP signalingStem cellsStem cell dynamicsChromatin marksNascent RNATranscriptional outputWhole-mount tissuesTranscriptional heterogeneityAxolotl salamanderGlial cell typesGene transcriptionRNA productionFISH probe setsNeural progenitorsMultiplexed fluorescenceRegenerative programNeural differentiationNSC population
2017
Transcriptional correlates of proximal-distal identify and regeneration timing in axolotl limbs
Voss S, Murrugarra D, Jensen TB, Monaghan JR. Transcriptional correlates of proximal-distal identify and regeneration timing in axolotl limbs. Comparative Biochemistry And Physiology Part C Toxicology & Pharmacology 2017, 208: 53-63. PMID: 29107037, PMCID: PMC5920805, DOI: 10.1016/j.cbpc.2017.10.010.Peer-Reviewed Original ResearchConceptsAxolotl limbsDynamic transcriptional regulationSimilar transcriptional patternsCell cycle transcriptsDifferentiated muscle cellsProximal-distal limb axisExtracellular matrix moleculesMemory genesTranscriptional regulationTranscript abundanceTranscriptional patternsExpression patternsLimb regenerationGene expressionBlastema cellsPositional memoryArm cellsCell adhesionGenesMatrix moleculesCell surfaceEpithelial proteinsPositional informationTissue remodelingTranscriptional correlatesEpidermal Growth Factor Receptor Family Signaling in the Regenerating Axolotl Lung
Jensen T, Giunta P, Schultz N, Wong H, Monaghan J. Epidermal Growth Factor Receptor Family Signaling in the Regenerating Axolotl Lung. The FASEB Journal 2017, 31: 615.8-615.8. DOI: 10.1096/fasebj.31.1_supplement.615.8.Peer-Reviewed Original ResearchLung regenerationLung tissueLung injuryNeuregulin-1EGF family receptorsEpidermal growth factor receptor familyGrowth factor receptor familyFactor receptor familyDistal thirdErbB4 mRNALung cellsLungCompensatory mechanismsFamily receptorsHealth careReceptor familyGrowth factor signalingReceptor heterodimersInjuryEpidermal growth factor signalingTissueFactor signalingNovel mechanismErbB2Proliferation
2015
Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target
Waters NJ, Daigle SR, Rehlaender BN, Basavapathruni A, Campbell CT, Jensen TB, Truitt BF, Olhava EJ, Pollock RM, Stickland KA, Dovletoglou A. Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target. Journal Of Controlled Release 2015, 220: 758-765. PMID: 26385168, DOI: 10.1016/j.jconrel.2015.09.023.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAntineoplastic AgentsBenzimidazolesBiological AvailabilityChemistry, PharmaceuticalDelayed-Action PreparationsDNA MethylationDogsDrug Administration ScheduleDrug CarriersEnzyme InhibitorsEpigenesis, GeneticGene Expression Regulation, LeukemicHistone-Lysine N-MethyltransferaseHumansInfusions, IntravenousInjections, SubcutaneousLeukemia, Biphenotypic, AcuteMaleMethyltransferasesMiceRats, Sprague-DawleyTumor BurdenXenograft Model Antitumor AssaysConceptsXenograft modelRefractory acute leukemia patientsFurther evaluationPhase 1 clinical trialSubcutaneous bolus administrationAcute leukemia patientsTumor growth inhibitionDOT1L inhibitor pinometostatExtended-release formulationRat xenograft modelMLL-r leukemiaThrice dailyPharmacodynamic markersSC administrationBolus administrationClinical trialsSubcutaneous administrationComplete bioavailabilityDOT1L activityLeukemia patientsOral administrationPatient conveniencePreclinical studiesSmall molecule inhibitorsImproved exposure