Monika P. Jadi, PhD
Assistant Professor of Psychiatry and of NeuroscienceCards
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Assistant Professor of Psychiatry and of Neuroscience
Biography
Monika Jadi obtained her Ph.D. in Neuroengineering at the University of Southern California and did her postdoctoral training at the Salk Institute for Biological Studies in the Computational Neurobiology Laboratory. At Yale, she is an Assistant Professor in the Departments of Psychiatry and Neuroscience.
Dr. Jadi’s research involves discovering computational principles that are critical for flexible information processing in the brain, using cross-disciplinary approaches from applied physics and computer science. Her doctoral research resulted in the first characterization of computational flexibility mediated by location-specificity of synaptic inhibition in active dendrites of neurons, a ubiquitous anatomical signature in cortical circuits. She has studied models of cortical networks during her postdoctoral work, and proposed a novel mechanism of cortical oscillations that is controlled by the direct and indirect stimulation of inhibitory neurons. Subsequently, she has explored mechanisms of flexible modulation of cortical dynamics that are mediated by different inhibitory neuronal classes in the cortex. Complementing her computational modelling work, she has used novel data analysis methods to explore the temporal dynamics of population coding in the visual cortex. The current focus of her lab is using computational modeling as well as data modeling tools such as machine learning to study computations, information flow, temporal dynamics of population codes and role of neuromodulation in canonical columnar circuits of the cortex. Dr. Jadi is a recipient of the NIH Pathway to Independence award during her postdoctoral and early faculty years.
Appointments
Psychiatry
Assistant ProfessorPrimaryNeuroscience
Assistant ProfessorSecondary
Other Departments & Organizations
Education & Training
- Postdoctoral Research Associate
- Salk Institute for Biological Studies (2017)
- PhD
- University of Southern California, Biomedical Engineering (2010)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0003-1092-5026- View Lab Website
Jadi Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Anirvan Nandy, PhD
Steve W. C. Chang, PhD
Cerebral Cortex
Dendrites
Interneurons
Schizophrenia
Computational Biology
Publications
2024
Brain-state mediated modulation of inter-laminar dependencies in visual cortex
Das A, Sheffield A, Nandy A, Jadi M. Brain-state mediated modulation of inter-laminar dependencies in visual cortex. Nature Communications 2024, 15: 5105. PMID: 38877026, PMCID: PMC11178935, DOI: 10.1038/s41467-024-49144-w.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsBrain state fluctuationsUnique dependenceSpatial attentionBehavioral outcomesState fluctuationsDeployment of spatial attentionDeployment of attentionBehaviorally relevant objectsComputational goalCluttered environmentsVisual cortexObject recognitionExcitatory populationHierarchical computationVisual area V4Internal fluctuationsDependenceRelevant objectsModulation patternsTask demandsEnhance information transferCortical networksNeural activityInformation transferArea V4
2023
The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors
Shi W, Meisner O, Blackmore S, Jadi M, Nandy A, Chang S. The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors. Neurobiology Of Learning And Memory 2023, 203: 107793. PMID: 37353191, PMCID: PMC10527225, DOI: 10.1016/j.nlm.2023.107793.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOrbitofrontal cortexOFC functionCognitive mapsOFC neuronsNon-social domainCore brain areasNon-social behaviorsReward-based behaviorsValues-based behaviorSocial behaviorSocial contextBrain areasBehavioral contextSocial functionComplex representationSingle subjectCortexBehaviorTremendous knowledgeIntegrated viewContextTask spaceMAP frameworkRepresentationWide array
2020
Correction: Optogenetically induced low-frequency correlations impair perception
Nandy AS, Nassi JJ, Jadi MP, Reynolds JH. Correction: Optogenetically induced low-frequency correlations impair perception. ELife 2020, 9: e55718. PMID: 32658639, PMCID: PMC7358006, DOI: 10.7554/elife.55718.Peer-Reviewed Original Research
2019
Optogenetically induced low-frequency correlations impair perception
Nandy A, Nassi JJ, Jadi MP, Reynolds J. Optogenetically induced low-frequency correlations impair perception. ELife 2019, 8: e35123. PMID: 30794156, PMCID: PMC6391072, DOI: 10.7554/elife.35123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2017
Cortical gamma band synchronization through somatostatin interneurons
Veit J, Hakim R, Jadi MP, Sejnowski TJ, Adesnik H. Cortical gamma band synchronization through somatostatin interneurons. Nature Neuroscience 2017, 20: 951-959. PMID: 28481348, PMCID: PMC5511041, DOI: 10.1038/nn.4562.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2016
Modulatory compartments in cortex and local regulation of cholinergic tone
Coppola JJ, Ward NJ, Jadi MP, Disney AA. Modulatory compartments in cortex and local regulation of cholinergic tone. Journal Of Physiology-Paris 2016, 110: 3-9. PMID: 27553093, PMCID: PMC5164978, DOI: 10.1016/j.jphysparis.2016.08.001.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCholinergic modulationCortical circuitsLocal cortical circuitsSubcellular receptor localizationCholinergic toneCholinergic systemReceptor expressionAxonal innervationModulatory inputsVisual pathwayLocal circuitsCortical tissueNeuromodulatory signalingReceptor localizationNeuromodulatory toneCortexPathological statesLocal regulationModulatory signalsExistence of compartmentsCompartmentsToneSpecific responsesSignalingInnervationNeurons in Macaque Area V4 Are Tuned for Complex Spatio-Temporal Patterns
Nandy AS, Mitchell JF, Jadi MP, Reynolds JH. Neurons in Macaque Area V4 Are Tuned for Complex Spatio-Temporal Patterns. Neuron 2016, 91: 920-930. PMID: 27499085, PMCID: PMC4990477, DOI: 10.1016/j.neuron.2016.07.026.Peer-Reviewed Original ResearchCitationsAltmetric
2015
Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Jadi MP, Behrens MM, Sejnowski TJ. Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia. Biological Psychiatry 2015, 79: 716-726. PMID: 26281716, PMCID: PMC4720598, DOI: 10.1016/j.biopsych.2015.07.005.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInhibitory neuronsGamma-band oscillationsNMDAR hypofunctionAnimal modelsN-methyl-D-aspartate (NMDA) receptor hypofunctionParvalbumin-expressing inhibitory neuronsAbnormal gamma oscillationsReceptor hypofunctionNMDAR antagonistsHypofunctionVisual cortexSZ symptomsSchizophreniaGamma oscillationsGenetic knockoutHuman subjectsBand oscillationsSymptomsNeuronsMagnetoencephalography (MEG) signalsPatientsAntagonistN-methylCortexNeuropharmacology
2014
An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites
Jadi MP, Behabadi BF, Poleg-Polsky A, Schiller J, Mel BW. An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites. Proceedings Of The IEEE 2014, 102: 782-798. PMID: 25554708, PMCID: PMC4279447, DOI: 10.1109/jproc.2014.2312671.Peer-Reviewed Original ResearchCitationsAltmetricRegulating Cortical Oscillations in an Inhibition-Stabilized Network
Jadi MP, Sejnowski TJ. Regulating Cortical Oscillations in an Inhibition-Stabilized Network. Proceedings Of The IEEE 2014, 102: 830-842. PMID: 24966414, PMCID: PMC4067313, DOI: 10.1109/jproc.2014.2313113.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements and Community Involvement
honor Pathway to Independence (K99/R00)
National AwardNational Eye InstituteDetails05/01/2015United States
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Locations
300 George Street
Academic Office
Ste 901
New Haven, CT 06511
Events
Yale Only Hyojung Seo, PhD - Matthew Girgenti, PhD - Jane Rebecca Taylor, PhD - Laura Marianne Huckins, PhD - George Dragoi, MD, PhD - Arie Kaffman, MD, PhD - Christopher Pittenger, MD, PhD - Alfred Kaye, MD, PhD - Monika P. Jadi, PhD - Alicia Y Che, PhD