2023
Characterization of the distribution and dynamics of chromatin states in the C. elegans germ line reveals substantial H3K4me3 remodeling during oogenesis
Mazzetto M, Gonzalez L, Sanchez N, Reinke V. Characterization of the distribution and dynamics of chromatin states in the C. elegans germ line reveals substantial H3K4me3 remodeling during oogenesis. Genome Research 2023, 34: gr.278247.123. PMID: 38164610, PMCID: PMC10903938, DOI: 10.1101/gr.278247.123.Peer-Reviewed Original ResearchEpigenetic regulatory mechanismsGerm lineChromatin stateGerm cellsC. elegans germ lineGene expressionRegulatory mechanismsDevelopmental transitionsActive histone modification H3K4me3Most genomic studiesZygotic genome activationSmall RNA pathwaysSpatio-temporal expression patternsHistone modifications H3K4me3Chromatin accessibility dataGerm cell differentiationOverall transcript abundanceUndifferentiated germ cellsGenome activationRNA pathwaysChromatin landscapeChromatin organizationChromatin structureEssential genesHistone modifications
2022
RNAseq Analysis of Brain Aging in Wild Specimens of Short-Lived Turquoise Killifish: Commonalities and Differences With Aging Under Laboratory Conditions
Mazzetto M, Caterino C, Groth M, Ferrari E, Reichard M, Baumgart M, Cellerino A. RNAseq Analysis of Brain Aging in Wild Specimens of Short-Lived Turquoise Killifish: Commonalities and Differences With Aging Under Laboratory Conditions. Molecular Biology And Evolution 2022, 39: msac219. PMID: 36318827, PMCID: PMC9641980, DOI: 10.1093/molbev/msac219.Peer-Reviewed Original ResearchConceptsAge-dependent gene expressionWild populationsGene expressionDifferent model speciesNumber of genesGene regulationModel speciesCaptive populationsDNA replicationWild fishTemporary pondsWild specimensAge-dependent regulationCaptive conditionsRNAseq analysisAbundant foodWild animalsGenesAfrican savannahAsymptotic sizeRegulationNeuronal communicationFishLaboratory conditionsEnvironmental challenges