In-Hyun Park, PhD
Associate Professor of GeneticsDownloadHi-Res Photo
Cards
Appointments
Genetics
Primary
Child Study Center
Secondary
Additional Titles
Yale Stem Cell Center
Contact Info
Appointments
Genetics
Primary
Child Study Center
Secondary
Additional Titles
Yale Stem Cell Center
Contact Info
Appointments
Genetics
Primary
Child Study Center
Secondary
Additional Titles
Yale Stem Cell Center
Contact Info
About
Titles
Associate Professor of Genetics
Yale Stem Cell Center
Appointments
Genetics
Associate Professor TenurePrimaryChild Study Center
Associate Professor on TermSecondary
Other Departments & Organizations
- Child Study Center
- Embryonic Stem Cell Research Oversight
- Genetics
- Interdepartmental Neuroscience Program
- Molecular Cell Biology, Genetics and Development
- Neural Disorders
- Neuroscience Track
- Park Lab
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Post-doc Fellow
- Harvard Medical School (2009)
- PhD
- University of Illinois at Urbana-Champaign (2005)
- MS
- Seoul National University (1999)
- BS
- Seoul National University (1994)
Research
Overview
- Investigation of genetic and epigenetic regulation of reprogramming
- in vitro model of human neurodevelopmental disease
Medical Research Interests
Cells; Central Nervous System Diseases; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Nervous System; Neural Stem Cells; Pluripotent Stem Cells; Psychiatry and Psychology; Stem Cells
ORCID
0000-0001-7748-1293- View Lab Website
the Park Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of In-Hyun Park's published research.
Publications Timeline
A big-picture view of In-Hyun Park's research output by year.
Research Interests
Research topics In-Hyun Park is interested in exploring.
Mei Zhong, PhD
Ferdi Kiral
Kun-Yong Kim, PhD
Flora Vaccarino, MD
Hai Feng Zhang
Jenny Huanjiao Zhou, MD, PhD
155Publications
19,740Citations
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Embryonic Stem Cells
Stem Cells
Neural Stem Cells
Cells
Publications
2025
Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches.
Cakir B, Tanaka Y, Choe M, Chu P, Xiang Y, Kim K, Zhong M, Gelernter J, Zhang H, Krystal J, Park I. Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. International Journal Of Stem Cells 2025 PMID: 40205763, DOI: 10.15283/ijsc24123.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cell linesAlcohol dependenceAD-associated variantsEmbryonic stem cell linesReporter gene analysisFyn tyrosine kinase geneTyrosine kinase geneStem cell linesCRISPR-Cas9 editingAssociated with ADVulnerability to ADAD-associatedKinase geneC alleleC/T allelesMultiple polymorphismsFunctional validationGene analysisEthanol treatmentNeuropsychiatric disordersInduced neuronsAD treatmentGene editingCell linesDisease mechanismsModeling forebrain regional development and connectivity by human brain organoids
Choe M, Lo C, Park I. Modeling forebrain regional development and connectivity by human brain organoids. Current Opinion In Genetics & Development 2025, 91: 102324. PMID: 39983347, DOI: 10.1016/j.gde.2025.102324.Peer-Reviewed Original Research
2024
High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis
Park S, Roh T, Tanaka Y, Kim Y, Park S, Kim T, Eom S, Park T, Park I, Kim S, Kim J. High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis. Neoplasia 2024, 60: 101116. PMID: 39724755, PMCID: PMC11729681, DOI: 10.1016/j.neo.2024.101116.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsP16<sup>INK4a</sup> expressionImmune cell infiltrationTumor cellsCell infiltrationImmunologically active tumor microenvironmentInfiltration of T cellsActive tumor microenvironmentTERT promoter mutationsExtended overall survivalIsocitrate dehydrogenase (IDH)-wildtypeSecretion of chemokinesSenescent phenotypeMalignant brain tumorsIn vitro studiesEGFR amplificationOverall survivalTumor microenvironmentCDKN2A/2B deletionT cellsPrognostic markerImprove prognosisP16INK4a expressionPromoter mutationsTumorBrain tumorsA framework for neural organoids, assembloids and transplantation studies
Pașca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, Knoblich J, Kriegstein A, Lancaster M, Ming G, Novarino G, Okano H, Parmar M, Park I, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino F, Vanderhaeghen P, Young-Pearse T. A framework for neural organoids, assembloids and transplantation studies. Nature 2024, 639: 315-320. PMID: 39653126, DOI: 10.1038/s41586-024-08487-6.Peer-Reviewed Original ResearchCitationsAltmetricMechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
Kural M, Djakbarova U, Cakir B, Tanaka Y, Chan E, Arteaga Muniz V, Madraki Y, Qian H, Park J, Sewanan L, Park I, Niklason L, Kural C. Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis. Cell Death & Disease 2024, 15: 440. PMID: 38909035, PMCID: PMC11193792, DOI: 10.1038/s41419-024-06822-3.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFas-induced apoptosisCell surface Fas expressionDeath receptor FasInhibition of endocytosisSurface Fas expressionPlasma membrane tensionCancer cell apoptosisEndocytosis dynamicsApoptotic signalingReceptor FasGlioblastoma cell growthFas expressionPlasma membraneCell growthEndocytosisXenograft mouse modelSoluble FasLCell apoptosisFasApoptosisRho-kinase inhibitorCancer cellsMembrane tensionNonmalignant cellsInduce tumor regressionIdentifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids
Kim J, Park I. Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids. Biological Psychiatry 2024, 95: 608-610. PMID: 38479977, DOI: 10.1016/j.biopsych.2024.01.015.Peer-Reviewed Original ResearchBrain organoids: from unguided to regionalized to nucleus-specific
Xiang Y, Park I. Brain organoids: from unguided to regionalized to nucleus-specific. Life Medicine 2024, 3: lnae014. PMID: 39872659, PMCID: PMC11748970, DOI: 10.1093/lifemedi/lnae014.Peer-Reviewed Original ResearchCitationsAltmetricTelencephalic organoids as model systems to study cortical development and diseases
Yang W, Kiral F, Park I. Telencephalic organoids as model systems to study cortical development and diseases. Organoid 2024, 4: e1. DOI: 10.51335/organoid.2024.4.e1.Peer-Reviewed Original ResearchCitations
2023
Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon
Kiral F, Choe M, Park I. Diencephalic organoids – A key to unraveling development, connectivity, and pathology of the human diencephalon. Frontiers In Cellular Neuroscience 2023, 17: 1308479. PMID: 38130869, PMCID: PMC10733522, DOI: 10.3389/fncel.2023.1308479.Peer-Reviewed Original ResearchCitationsConceptsHuman diencephalonBrain organoidsNeurodevelopmental disordersDevelopmental brain disordersHuman brain tissueThalamocortical connectionsBrain disordersDiencephalic developmentBrain tissueDiencephalic structuresOrganoid modelsHuman-specific aspectsSensory processingDiencephalonDisordersTelencephalic fatePathologyStem cellsStem cell technologyOrganoidsGENERATION OF BRAIN ORGANOIDS TO STUDY HUMAN BRAIN DEVELOPMENT AND DISEASES
Yang W, Park I. GENERATION OF BRAIN ORGANOIDS TO STUDY HUMAN BRAIN DEVELOPMENT AND DISEASES. IBRO Neuroscience Reports 2023, 15: s48. DOI: 10.1016/j.ibneur.2023.08.2149.Peer-Reviewed Original Research
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The Park Lab
Lab
Amistad Street Building
10 Amistad Street, Ste 214J
New Haven, CT 06519
Appointments
203.737.5173