Ilan Harpaz-Rotem, PhD, ABPP
Professor of Psychiatry and of PsychologyCards
Appointments
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
Appointments
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
Appointments
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
About
Titles
Professor of Psychiatry and of Psychology
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Positions outside Yale
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Biography
Dr. Harpaz-Rotem is a Professor of Psychiatry and of Psychology at Yale University. He is a clinical psychologist who, for many years, has conducted research and provided treatment to individuals exposed to trauma. Dr. Harpaz-Rotem serves as an investigator at the National Center for PTSD, and he also directs the evaluation of VA PTSD treatment programs at the Department of Veterans Affairs, Northeast Program Evaluation Center, Office of Mental Health and Suicide Prevention, VA Central Office. Research into how to modify traumatic memories and their associated emotions is one of the core questions that guide his work.
Appointments
Psychiatry
ProfessorPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Division of Mental Health Services
- Harpaz-Rotem Lab
- MR Center
- Psychiatry
- Psychology Section
- VA National Center for PTSD
- VA-Yale Clinical Neurosciences PTSD Research Program
- Yale Ventures
Education & Training
- Postdoc
- NIH NRSA Postdoctoral Fellowship Yale University Department of Psychiatry (2004)
- PhD
- New School for Social Research (2002)
- Clinical training
- University of California at Davis School of Medicine (2002)
- Clinical training
- Albert Einstein School of Medicine Bronx Lebanon Hospital (2001)
- Clinical training
- New York University Medical Center & Bellevue Hospital (2000)
- Clinical training
- Beth Israel Medical Center (1998)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0002-6066-9406- View Lab Website
Harpaz-Rotem PTSD Treatment & Research Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Jack Tsai
Or Duek, PhD
John Krystal, MD
Robert Pietrzak, PhD, MPH
Georgina Gross, PhD
Ifat Levy, PhD
Stress Disorders, Post-Traumatic
Veterans
Mental Health Services
Psychotherapy
Magnetic Resonance Imaging
Depression
Publications
2024
Unveiling the Structure in Mental Disorder Presentations
Spiller T, Duek O, Helmer M, Murray J, Fielstein E, Pietrzak R, von Känel R, Harpaz-Rotem I. Unveiling the Structure in Mental Disorder Presentations. JAMA Psychiatry 2024, 81 PMID: 39110437, PMCID: PMC11307158, DOI: 10.1001/jamapsychiatry.2024.2047.Peer-Reviewed Original ResearchAltmetricConceptsSymptom combinationsNational Institute of Mental Health Data ArchivePosttraumatic stress disorderDiagnostic criteriaHeterogeneity of symptomsSecondary data analysisCross-sectional studyRevision of diagnostic criteriaSymptom-based definitionsDSM criteriaStress disorderSymptom heterogeneityDisorder presentationsClinical populationsMain OutcomesAssess symptomsGroup of individualsParticipantsSymptomsNational InstituteDisordersIndividualsSchizophreniaAnxietyIndividual frequenciesPost-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 343: 111864. PMID: 39111111, DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchConceptsReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changesUnraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchAltmetricConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransBarriers to Mental Health Care in US Military Veterans
Lewis C, Fischer I, Tsai J, Harpaz-Rotem I, Pietrzak R. Barriers to Mental Health Care in US Military Veterans. Psychiatric Quarterly 2024, 1-17. PMID: 38940875, DOI: 10.1007/s11126-024-10078-7.Peer-Reviewed Original ResearchConceptsMental health careMental health treatmentHealth careHealth treatmentReduce barriersUS veteransNegative beliefsInstrumental barriersNational Health and ResiliencePromote engagementMental health servicesPopulation-based effortsUS military veteransNationally representative dataMultivariate logistic regressionPerceived stigmaHealth servicesSocial supportPsychiatric needsVeterans StudyPractical barriersLow purposeConclusionsNearly halfMilitary veteransCare41. Neurobehavioral Mapping of Posttraumatic Stress Disorder Development in Recent Trauma Survivors
Ben-Zion Z, Lee K, Fonteneau C, Liberzon I, Shalev A, Hendler T, Levy I, Anticevic A, Harpaz-Rotem I. 41. Neurobehavioral Mapping of Posttraumatic Stress Disorder Development in Recent Trauma Survivors. Biological Psychiatry 2024, 95: s92. DOI: 10.1016/j.biopsych.2024.02.219.Peer-Reviewed Original Research351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. 351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD. Biological Psychiatry 2024, 95: s243. DOI: 10.1016/j.biopsych.2024.02.850.Peer-Reviewed Original ResearchEmotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. Emotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder. JAMA Network Open 2024, 7: e246813. PMID: 38625701, PMCID: PMC11022112, DOI: 10.1001/jamanetworkopen.2024.6813.Peer-Reviewed Original ResearchAltmetricConceptsPosttraumatic stress disorderTrauma-exposed individualsEmotional numbing symptomsTrauma-exposed controlsNegative emotional statesNumbing symptomsEmotional numbingDSM-5Valence ratingsStress disorderEmotional statesTrauma-exposed control groupPTSD experiencesPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistDSM-5 criteriaAge-related associationsStimulus valencePCL-5Emotional responsesEmotional state transitionEmotional transitionSymptomsParticipantsDisordersSome Closure on Exposure—Realigning the Perspective on Trauma Treatment and Finding a Pathway Forward: Reply to Brown (2024) and Najavits (2024)
Rubenstein A, Doran J, Duek O, Harpaz-Rotem I. Some Closure on Exposure—Realigning the Perspective on Trauma Treatment and Finding a Pathway Forward: Reply to Brown (2024) and Najavits (2024). American Psychologist 2024, 79: 350-351. PMID: 38635198, DOI: 10.1037/amp0001314.Peer-Reviewed Original ResearchAltmetricTo Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder
Rubenstein A, Duek O, Doran J, Harpaz-Rotem I. To Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder. American Psychologist 2024, 79: 331-343. PMID: 38635195, PMCID: PMC11034887, DOI: 10.1037/amp0001121.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPosttraumatic stress disorderTreating posttraumatic stress disorderNon-trauma-focused treatmentsExposure therapyStress disorderTreatment of posttraumatic stress disorderNon-trauma-focused therapiesPosttraumatic stress disorder diagnosisSelf-directed exposureTrauma-focused psychotherapyPsychotherapy factorsTrauma memoriesTrauma-focusedBehavioral paradigmsSymptom remissionHigh dropout ratesTherapy processTherapy contextProlonged exposurePsychotherapyDropout ratesIncreased patient autonomyResearch literatureDisordersClinical researchFunctional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2024, 171: 69-74. PMID: 38244335, DOI: 10.1016/j.jpsychires.2024.01.017.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsModels of posttraumatic stress disorderPosttraumatic stress disorderNational Health and ResilienceU.S. military veteransArousal symptomsSuicidal ideationVeterans StudyCurrent depressionSymptom clustersMilitary veteransPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistAnxious arousal symptomsDysphoric arousal symptomsIntrusive symptom clustersOdds of suicidal ideationFunctional correlatesMulti-faceted disorderExternalizing behavioral symptomsAssociated with lower oddsAssociated with higher oddsSymptom structureAvoidance symptomsDSM-5
Clinical Trials
Current Trials
Eligibility for Participation in Neuroimaging Studies
HIC ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsUsing Neuroimaging to track symptom change in PTSD treatment
HIC ID2000025892RolePrincipal InvestigatorPrimary Completion Date07/31/2029Recruiting ParticipantsImaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
HIC ID1005006735RoleSub InvestigatorPrimary Completion Date12/31/2016Recruiting ParticipantsGenderMaleAge18 years - 55 yearsNeurofeedback of Amygdala Activity for Post-traumatic Stress Disorder (PTSD)
HIC ID2000022668RolePrincipal InvestigatorPrimary Completion Date06/30/2023Recruiting ParticipantsGenderBothAge18+ yearsImaging mGluR5 and synaptic density in psychiatric disorders
HIC ID2000020186RoleSub InvestigatorPrimary Completion Date01/31/2018Recruiting ParticipantsGenderBothAge18 years - 80 years
Academic Achievements and Community Involvement
honor Distinguished Mentorship Award
National AwardInternational Society for Traumatic Stress Studies (ISTSS)Details11/11/2022United States
Links & Media
News
- August 07, 2024Source: Yale News
Mental Disorder Symptoms Present in Predictable Ways
- May 03, 2024Source: Yale News
Rapid Emotion Transitions May Explain Numbness and Hyperreactivity in PTSD
- April 23, 2024Source: APA PsycNet
To Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder
- February 08, 2024
Harpaz-Rotem to Speak at SOBP Symposium
Get In Touch
Contacts
Psychiatry
300 George Street
New Haven, CT 06511
United States
Locations
300 George Street
Academic Office
Rm 836
New Haven, CT 06511