2005
Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth
Bryan B, Cai Y, Wrighton K, Wu G, Feng X, Liu M. Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth. FEBS Letters 2005, 579: 1015-1019. PMID: 15710384, DOI: 10.1016/j.febslet.2004.12.074.Peer-Reviewed Original ResearchConceptsRhoA protein levelsNeurite outgrowthE3 ubiquitin ligaseProteasome inhibitor MG132Protein levelsNon-neuronal cell typesIntracellular asymmetryCell polarityRho familyRho GTPasesUbiquitin ligasePromotes Neurite OutgrowthSubsequent ubiquitinationProteasomal degradationProtrusive activityEssential regulatorInhibitor MG132RhoA activitySmurf1Axonal pathfindingUbiquitinationNeuro2a cellsRhoACell typesProtrusion sites
2004
GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*
Bryan B, Kumar V, Stafford L, Cai Y, Wu G, Liu M. GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*. Journal Of Biological Chemistry 2004, 279: 45824-45832. PMID: 15322108, DOI: 10.1074/jbc.m406216200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCdc42 GTP-Binding ProteinCells, CulturedGuanine Nucleotide Exchange FactorsHumansNeuritesNF-kappa BP21-Activated KinasesProtein Serine-Threonine KinasesRac1 GTP-Binding ProteinRatsRats, Sprague-DawleyRho Guanine Nucleotide Exchange FactorsTranscription Factor AP-1Transcriptional ActivationConceptsGuanine nucleotide exchange factorsNucleotide exchange factorsExchange factorRho family guanine nucleotide-exchange factorNeurite outgrowthState of Rac1Dendritic spine formationCell fate determinationActin cytoskeletal organizationExchange of GDPActivation of RacNormal cell growthRac1/Cdc42Spine formationFate determinationEukaryotic cellsGene regulationNeuroblastoma cellsSmall GTPasesActive GTPDbl familyRho familyCellular processesRho GTPasesCytoskeletal organization