The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations
Diederichs S, Bartsch L, Berkmann JC, Fröse K, Heitmann J, Hoppe C, Iggena D, Jazmati D, Karschnia P, Linsenmeier M, Maulhardt T, Möhrmann L, Morstein J, Paffenholz SV, Röpenack P, Rückert T, Sandig L, Schell M, Steinmann A, Voss G, Wasmuth J, Weinberger ME, Wullenkord R. The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations. EMBO Molecular Medicine 2016, 8: 442-457. PMID: 26992833, PMCID: PMC5126213, DOI: 10.15252/emmm.201506055.Peer-Reviewed Original ResearchConceptsCancer genomesSynonymous mutationsProtein-coding sequencesNon-coding sequencesNon-coding RNANon-coding RNAsDeep sequencing studiesTumor suppressor geneTP53/p53Gene regulationSplicing patternsRegulatory elementsProtein sequencesMRNA stabilityGenetic elementsGenomeUntranslated regionSequencing studiesSplice siteSplice site mutationSuppressor geneOncogene activationFunctional studiesSite mutationNovel mechanism