Genetics Department Seminar Series: "Design principles of tissue organization during organoid development"

Multicellular organisms are composed of cells with identical genomes but different properties and functions. They all develop from one cell to form multicellular structures of astounding complexity. I will present how cellular interactions generate emergent tissue scale properties and drive spatio-temporal coordination during development and regeneration. Moreover, I will present the molecular mechanisms underlying intestinal organoid self-organization and the role of cell-to-cell variability in populations of differentiating cells during symmetry breaking.