1998
Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities
Kaldis P, Russo A, Chou H, Pavletich N, Solomon M. Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities. Molecular Biology Of The Cell 1998, 9: 2545-2560. PMID: 9725911, PMCID: PMC25525, DOI: 10.1091/mbc.9.9.2545.Peer-Reviewed Original ResearchConceptsTranscription factor IIHC-terminal domainSubstrate specificityCDK/cyclin complexesCTD kinase activityRNA polymerase IIDistinct substrate specificitiesDifferent substrate specificitiesCyclin-dependent kinasesCell cycle progressionHuman CAKYeast CdkEnzyme-substrate recognitionPolymerase IILarge subunitTranscriptional componentsCak1pCDK activationCyclin complexesKey residuesKinase activitySingle polypeptideCycle progressionCDK inhibitorsCDK
1995
KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity
Cismowski M, Laff G, Solomon M, Reed S. KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity. Molecular And Cellular Biology 1995, 15: 2983-2992. PMID: 7760796, PMCID: PMC230529, DOI: 10.1128/mcb.15.6.2983.Peer-Reviewed Original ResearchConceptsC-terminal domainKinase activityCTD kinaseMRNA transcriptionCritical threonine residueCyclin-dependent kinase familyCTD kinase activityRNA polymerase IICell cycle CDKsExtensive sequence identityCyclin-dependent kinasesThermosensitive alleleCTD phosphorylationPolymerase IIThreonine residuesKinase familyPositive regulatorKin28Phosphorylation stateS. cerevisiaeSequence identityCell cycleTranscriptionHuman cellsCDK