2019
The association between fluconazole dose and MIC with mortality and persistence in candidemia
Ghanem-Zoubi N, Qasum M, Khoury J, Zorbavel D, Arnon M, Geffen Y, Paul M. The association between fluconazole dose and MIC with mortality and persistence in candidemia. European Journal Of Clinical Microbiology & Infectious Diseases 2019, 38: 1773-1780. PMID: 31197619, DOI: 10.1007/s10096-019-03611-1.Peer-Reviewed Original ResearchConceptsAUC24/MICClinical outcomesC. glabrata candidemiaComposite of mortalityExposure parametersLowest MIC valueSimilar non-significant differencesFluconazole doseFluconazole dosingPersistent candidemiaSingle centerMIC valuesClinical failureInclusion criteriaCandidemiaPatientsDay 14Non-significant differenceHigh MICsFluconazole MICsStudy periodMortalityCandida speciesMICC. glabrata
2014
Alkaline phosphatase level change in patients with osteosarcoma: its role as a predictive factor of tumor necrosis and clinical outcome.
Khoury J, Ben-Arush M, Weintraub M, Waldman E, Futerman B, Vlodavsky E, Postovsky S. Alkaline phosphatase level change in patients with osteosarcoma: its role as a predictive factor of tumor necrosis and clinical outcome. Israel Medical Association Journal 2014, 16: 26-32. PMID: 24575501.Peer-Reviewed Original ResearchConceptsTumor necrosisBetter prognosisClinical outcomesPredictive factorsHistological responseBetter survivalSerum alkaline phosphatase levelsEvidence of diseaseSignificant predictive factorsAlkaline phosphatase levelsNeoadjuvant chemotherapyOverall survivalWorse survivalFemale patientsMedical filesOsteosarcoma patientsPatientsPhosphatase levelsSAP responseNecrosisFirst monthRespondersPredictive indicatorDiseaseSurvival