2014
Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete
Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, DePonte K, Fish D, Fikrig E. Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.Peer-Reviewed Original ResearchConceptsPeritrophic matrixTranscription factor signal transducerPathogen colonizationLyme disease spirochete Borrelia burgdorferiActivator of transcriptionGut microbiotaArthropod gutsSignal transducerLyme disease spirocheteFunctional linkArthropod vectorsMajor vectorKey glycoproteinsHuman pathogensSpirochete Borrelia burgdorferiGut epitheliumIxodes scapularis ticksColonizationGut epithelial barrierMicrobiotaExpressionGut lumenScapularis ticksBorrelia burgdorferiEpithelial barrier
2004
An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
Tsao J, Wootton J, Bunikis J, Luna M, Fish D, Barbour A. An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 18159-18164. PMID: 15608069, PMCID: PMC536054, DOI: 10.1073/pnas.0405763102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiCommunicable DiseasesDisease ReservoirsEcologyGenotypeGlutathione TransferaseHumansImmunoenzyme TechniquesIxodesLipoproteinsLyme DiseaseMicePeromyscusPolymerase Chain ReactionRecombinant Fusion ProteinsTicksVaccinesConceptsWild white-footed miceTick infection prevalenceNegative control antigenReservoir host speciesVector-borne diseasesSympatric ticksField experimentDisease cycleB. burgdorferiDisease incidenceDisease agentsArthropod vectorsEcological approachAnimal reservoirsImmunization of humansMouse densityTicksHost speciesLyme disease agentInfection dynamicsHuman vaccinesPopulation structureWhite-footed miceOuter surface protein AHuman infections