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Diana Martínez Saucedo, PhD

she/her/hers
Postdoctoral Associate
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Education

PhD
Universidad Nacional Autonoma de Mexico, Biomedical Sciences (2019)


BS
Universidad Nacional Autonoma de Mexico, Biologia (2011)


About

Titles

Postdoctoral Associate

Biography

My goal is to develop novel therapies for pancreatic cancer by understanding how alternative splicing drives antitumor immunity and serves as a potential therapeutic target.

I earned my Ph.D. in Biomedical Sciences at the National Autonomous University of Mexico (UNAM). My research projects aimed to elucidate pathways and mechanisms associated with anti-inflammatory M2-macrophages to reduce the inflammatory process. During my Ph.D., I discovered that microRNAs are crucial to reducing the expression of inflammatory mediators in macrophages and inducing the expression of M2-associated molecules. This finding suggests reprogramming macrophages through the identified pathways can guide the development of new therapies across inflammatory pathologies in MS and diabetes type 1, among others.

This understanding of post-transcriptional events' impact on cells motivated me to study the role of alternative splicing in one of the most aggressive and therapeutically resistant cancers: Pancreatic cancer. Understanding the microenvironment of the tumors, tumor cell interaction with the immune system, and the role of splicing in these contexts is crucial to developing better therapeutic approaches.

Postdoctoral Fellowship: Leslie Warner, Yale Cancer Center.

Appointments

Departments & Organizations

Education & Training

PhD
Universidad Nacional Autonoma de Mexico, Biomedical Sciences (2019)
Research Associate
Nationwide Children's Hospital (2017)
BS
Universidad Nacional Autonoma de Mexico, Biologia (2011)

Research

Research at a Glance

Publications Timeline

A big-picture view of Diana Martínez Saucedo's research output by year.
7Publications
16Citations

Publications

2019

2018

2017

2015

Academic Achievements & Community Involvement

  • activity

    Altered splicing mimics chromosome loss and drives pancreatic cancer

  • activity

    Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

  • honor

    Leslie H. Warner Fellowship

Teaching & Mentoring

Mentoring

  • Deanne Yugawa

    Graduate student
    2022 - 2025

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