2021
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling
Matsubara Y, Gonzalez L, Kiwan G, Liu J, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Mori M, Dardik A. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2909-2922. PMID: 34670406, PMCID: PMC8664128, DOI: 10.1161/atvbaha.121.316380.Peer-Reviewed Original ResearchConceptsPD-L1AVF maturationPD-L1 activityVenous remodelingT cellsL1 antibodyArteriovenous fistulaNude miceMouse aortocaval fistula modelEnd-stage renal diseaseT helper type 2 cellsT helper type 1 (Th1) cellsPrimary success rateSmooth muscle cell proliferationRegulatory T cellsT cell activityT-cell transferAortocaval fistula modelPreferred vascular accessVascular wall thickeningM1-type macrophagesM2-type macrophagesPotential therapeutic targetMuscle cell proliferationType 1 cells
2012
Neointimal Hyperplasia: Basic Considerations
Model L, Dardik A. Neointimal Hyperplasia: Basic Considerations. 2012, 178-196. DOI: 10.1002/9781118481370.ch10.ChaptersSmooth muscle cell proliferationMuscle cell proliferationNeointimal hyperplasiaIII trialsBypass graft failureCell proliferationVein graft adaptationVein graft restenosisExtracellular matrix depositionGraft failureVein graftsVascular surgeonsVascular surgeryGraft restenosisGraft adaptationNew molecular mechanismHyperplasiaTrialsRestenosisMatrix depositionBody responseArterial environmentMolecular mechanismsDisappointing failuresProliferation