Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these two hallmarks of cancer are related remains poorly understood. By integrating genetic, epigenetic, and functional analyses at the single cell level, we show that progression of uveal melanoma (UM), the most common intraocular primary cancer in adults, is driven by loss of Polycomb Repressive Complex 1 (PRC1) in a subpopulation of tumor cells. This leads to transcriptional de-repression of PRC1-target genes and mitotic chromosome segregation errors. Ensuing CIN leads to the formation of rupture-prone micronuclei, exposing genomic double-stranded DNA (dsDNA) to the cytosol. This provokes tumor cell-intrinsic inflammatory signaling, mediated by aberrant activation of the cGAS-STING pathway. Read more...Source: Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
Too much screen time: Eye doctors seeing more preventable vision issues in children during pandemic
NEW HAVEN, Conn. (WTNH) — Another COVID-19 pandemic health-related issue doctors are now treating is children’s vision after months and months of too much screen time. That can lead to a condition called myopia, which is nearsightedness.Source: News 8 WTNH.com
Carefully, Yale Labs Stir to Life Across Campus
Since June 1, the start of a broad, three-phase reactivation of campus, an estimated 4,000 faculty members, graduate students, and staff representing more than 500 labs around Yale have fired up microscopes, opened fume hoods, or dusted off other essential research equipment.Source: YaleNews
The gift of sight
Yale opthalmologist Dr. Christopher Teng recently traveled to Haridwar, India to participate in an educational outreach program. A team from Operation Restore Vision, a non-profit organization of which Teng is a member, traveled to The Hans Foundation Eye Hospital in Haridwar to teach and perform eye surgery.