Genetics Clinical Grand Rounds: Diagnostic RNA-seq analysis using trans-differentiated clinically accessible tissues

Program Objective(s):

1 Describe the different modes of molecular abnormalities that can be detected by bulk RNA-seq analysis.

2 Recognize the benefits and limitations of RNA-seq in facilitating variant interpretation for WGS

3 Understand the approaches to modulate gene expression in order to maximize the diagnostic value of RNA-seq data