Genetics Clinical Grand Rounds

ACMG points to consider regarding the incidental detection of:

• acquired /somatic variants in germline genetic testing

• germline variants in tumor genetic testing

The first part of this presentation will review the ACMG points to consider for the incidental detection of acquired/somatic variants in NGS testing for inherited disorders (ACMG statement, PMID: 33864022). These variants can arise due to postzygotic mosaicism or be specific to the hematopoietic cell lineage.

The second part of this presentation will discuss the ACMG points to consider for reporting clinically significant germline variants in patients undergoing tumor testing (ACMG statement, PMID: 32321997). These germline variants can be associated with hereditary cancer susceptibility, as well as other conditions.