Brain Microdialysis and Stimulation in Epilepsy

Major goal in our laboratory is to elucidate the neurochemical mechanisms underlying epilepsy using brain microdialysis, intracranial electrode recording and stimulation in conscious neurosurgical epilepsy patients. We are also interested in the neurochemical and electrophysiological changes during cognitive processing, sleep, and in the effects of sex steroids on brain neurochemistry. HPLC is used to analyze the microdialysate samples obtained from the human brain for several neurotransmitters and neurometabolites. Another line of research is to study the effects of direct brain stimulation on neurotransmitter dynamics and brain excitability in order to develop better treatments for brain disorders such as refractory epilepsy and depression. The work involves close collaboration between the departments of neurosurgery, neurology and psychiatry. For further information contact: