Gail D'Onofrio, MD, MS

Professor of Emergency Medicine; Chair, Department of Emergency Medicine

Research Interests

Pharmaceutical Preparations; Chemicals and Drugs

Research Organizations

Program in Addiction Medicine

SBIRT Training in Yale Residency Programs

Office of Cooperative Research

Research Summary

Dr. D’Onofrio is internationally known for her work in screening ED patients for alcohol and other drug use, brief intervention, and referral to treatment (SBIRT). She has received two NIAAA RO1 grants for ED practitioner-performed brief interventions for harmful and hazardous drinking (Project ED Health I and II). She is also PI on a NIDA RO1 for screening, intervention, treatment and referral of patients with opioid dependence (Project ED Health III). In addition, she is the PI on a UO1 from SAMHSA that trains residents in all primary care specialties including Emergency Medicine Primary Care, Internal Medicine, Med/Peds, Pediatrics, OB/GYN and Psychiatry on SBIRT.

For the past 25 years she has developed and tested empirically ED interventions for SUDs, serving as PI on multiple RO1s from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA), and most recently is a lead investigator on a multi-site NIDA CTN trial related to implementation science and opioid use disorder (OUD). A national expert in Women and Heart Disease, Dr. D’Onofrio has been an integral part of the Yale New Haven Hospital Women’s Heart Program. She completed a two-year Department of Health and Human Services (DHHS) grant evaluating targeted interventions for women with cardiac risk factors in the ED Chest Pain Center. She is also a senior co-investigator on a large NHLBI grant studying young women with acute MI, enrolling at over 100 sites nationally (PI: Krumholz). 

She has published numerous papers related to women in heart disease, serving as a senior investigator in the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study, funded by NHLBI and published multiple papers documenting the disparities in reperfusion, and differences in symptom presentation and classification of disease among young women and men with acute myocardial infarction.

Dr. D'Onofrio also serves as a mentor on several other grants funded and submitted by other DEM faculty. She routinely sits on review panels for NIDA, NIAAA and NHLBI. She is a founding member, representing Emergency Medicine, on the American Board of Addiction Medicine.

Selected Publications

Full List of PubMed Publications

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Contact Info

Gail D'Onofrio, MD, MS
Patient Care Location
Adult Emergency DepartmentYale New Haven Hospital
20 York Street, Ste Pavilion 218

New Haven, CT 06510
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Mailing Address
Emergency MedicineYale School of Medicine
464 Congress Ave., Suite 260

New Haven, CT 06519-1315
SAEM Pulse Cover article: "Physician at the Forefront" an interview with Gail D'Onofrio

Dr. Gail D'Onofrio is featured in SAEM Pulse, the magazine of the Society for Academic Emergency Medicine, for her groundbreaking research on ED-Initiated Treatment for Opioid Use Disorder