Model Information	
Data Set	WORK.MENTHOL	
Dependent Variable	smaxstim	
Covariance Structure	Variance Components	
Estimation Method	REML	
Residual Variance Method	Profile	
Fixed Effects SE Method	Model-Based	
Degrees of Freedom Method	Containment	

Class Level Information	
Class	Levels	Values	
ID	57	M0001 M0002 M0003 M0004 M0005 M0006 M0007 M0008 M0009 M0010 M0011 M0012 M0013 M0014 M0015 M0016 M0018 M0019 M0020 M0021 M0022 M0023 M0025 M0026 M0028 M0029 M0030 M0031 M0032 M0033 M0034 M0035 NM001 NM002 NM003 NM004 NM005 NM006 NM007 NM008 NM009 NM010 NM012 NM013 NM014 NM015 NM016 NM017 NM018 NM019 NM020 NM022 NM023 NM024 NM025 NM026 NM028	
MENTHOL	3	HM LM PM	
MENTHOLATED	2	M N	
NICOTINE	3	HIGH LOW SALINE	
SESSION	3	1 2 3	
PERIOD	3	1 2 3	

Dimensions	
Covariance Parameters	4	
Columns in X	54	
Columns in Z	371	
Subjects	1	
Max Obs per Subject	430	

Number of Observations	
Number of Observations Read	432	
Number of Observations Used	430	
Number of Observations Not Used	2	

Iteration History	
Iteration	Evaluations	-2 Res Log Like	Criterion	
0	1	1906.21098997		
1	3	1719.37453948	0.00008917	
2	1	1719.33004768	0.00000019	
3	1	1719.32995406	0.00000000	

Convergence criteria met.	

Covariance Parameter Estimates	
Cov Parm	Estimate	
ID	2.1572	
MENTHOL(ID)	0.2020	
NICOTINE(ID)	0.8402	
Residual	1.8756	

Fit Statistics	
-2 Res Log Likelihood	1719.3	
AIC (Smaller is Better)	1727.3	
AICC (Smaller is Better)	1727.4	
BIC (Smaller is Better)	1735.5	

Solution for Fixed Effects	
Effect	MENTHOL	MENTHOLATED	NICOTINE	SESSION	PERIOD	Estimate	
Intercept						2.8268	
MENTHOL	HM					-0.03543	
MENTHOL	LM					0.3600	
MENTHOL	PM					0	
MENTHOLATED		M				-0.09607	
MENTHOLATED		N				0	
MENTHOL*MENTHOLATED	HM	M				0.4863	
MENTHOL*MENTHOLATED	HM	N				0	
MENTHOL*MENTHOLATED	LM	M				-0.4485	
MENTHOL*MENTHOLATED	LM	N				0	
MENTHOL*MENTHOLATED	PM	M				0	
MENTHOL*MENTHOLATED	PM	N				0	
NICOTINE			HIGH			3.8484	
NICOTINE			LOW			1.5775	
NICOTINE			SALINE			0	
MENTHOL*NICOTINE	HM		HIGH			-0.00441	
MENTHOL*NICOTINE	HM		LOW			0.9538	
MENTHOL*NICOTINE	HM		SALINE			0	
MENTHOL*NICOTINE	LM		HIGH			-0.2948	
MENTHOL*NICOTINE	LM		LOW			0.1083	
MENTHOL*NICOTINE	LM		SALINE			0	
MENTHOL*NICOTINE	PM		HIGH			0	
MENTHOL*NICOTINE	PM		LOW			0	
MENTHOL*NICOTINE	PM		SALINE			0	
MENTHOLATED*NICOTINE		M	HIGH			-1.6970	
MENTHOLATED*NICOTINE		M	LOW			-1.2498	
MENTHOLATED*NICOTINE		M	SALINE			0	
MENTHOLATED*NICOTINE		N	HIGH			0	
MENTHOLATED*NICOTINE		N	LOW			0	
MENTHOLATED*NICOTINE		N	SALINE			0	
MENTHO*MENTHO*NICOTI	HM	M	HIGH			-0.8809	
MENTHO*MENTHO*NICOTI	HM	M	LOW			-0.8899	
MENTHO*MENTHO*NICOTI	HM	M	SALINE			0	
MENTHO*MENTHO*NICOTI	HM	N	HIGH			0	
MENTHO*MENTHO*NICOTI	HM	N	LOW			0	
MENTHO*MENTHO*NICOTI	HM	N	SALINE			0	
MENTHO*MENTHO*NICOTI	LM	M	HIGH			0.7889	
MENTHO*MENTHO*NICOTI	LM	M	LOW			1.2712	
MENTHO*MENTHO*NICOTI	LM	M	SALINE			0	
MENTHO*MENTHO*NICOTI	LM	N	HIGH			0	
MENTHO*MENTHO*NICOTI	LM	N	LOW			0	
MENTHO*MENTHO*NICOTI	LM	N	SALINE			0	
MENTHO*MENTHO*NICOTI	PM	M	HIGH			0	
MENTHO*MENTHO*NICOTI	PM	M	LOW			0	
MENTHO*MENTHO*NICOTI	PM	M	SALINE			0	
MENTHO*MENTHO*NICOTI	PM	N	HIGH			0	
MENTHO*MENTHO*NICOTI	PM	N	LOW			0	
MENTHO*MENTHO*NICOTI	PM	N	SALINE			0	
SESSION				1		0.3754	
SESSION				2		-0.2697	
SESSION				3		0	
PERIOD					1	0.2674	
PERIOD					2	0.09355	
PERIOD					3	0	

Solution for Fixed Effects	
Effect	MENTHOL	MENTHOLATED	NICOTINE	Standard Error	DF	t Value	Pr > |t|	
Intercept				0.5126	55	5.52	<.0001	
MENTHOL	HM			0.4540	85	-0.08	0.9380	
MENTHOL	LM			0.4537	85	0.79	0.4297	
MENTHOL	PM			.	.	.	.	
MENTHOLATED		M		0.6410	163	-0.15	0.8810	
MENTHOLATED		N		.	.	.	.	
MENTHOL*MENTHOLATED	HM	M		0.6095	163	0.80	0.4261	
MENTHOL*MENTHOLATED	HM	N		.	.	.	.	
MENTHOL*MENTHOLATED	LM	M		0.6061	163	-0.74	0.4604	
MENTHOL*MENTHOLATED	LM	N		.	.	.	.	
MENTHOL*MENTHOLATED	PM	M		.	.	.	.	
MENTHOL*MENTHOLATED	PM	N		.	.	.	.	
NICOTINE			HIGH	0.5201	105	7.40	<.0001	
NICOTINE			LOW	0.5130	105	3.07	0.0027	
NICOTINE			SALINE	.	.	.	.	
MENTHOL*NICOTINE	HM		HIGH	0.6103	163	-0.01	0.9942	
MENTHOL*NICOTINE	HM		LOW	0.6035	163	1.58	0.1159	
MENTHOL*NICOTINE	HM		SALINE	.	.	.	.	
MENTHOL*NICOTINE	LM		HIGH	0.6131	163	-0.48	0.6313	
MENTHOL*NICOTINE	LM		LOW	0.6069	163	0.18	0.8586	
MENTHOL*NICOTINE	LM		SALINE	.	.	.	.	
MENTHOL*NICOTINE	PM		HIGH	.	.	.	.	
MENTHOL*NICOTINE	PM		LOW	.	.	.	.	
MENTHOL*NICOTINE	PM		SALINE	.	.	.	.	
MENTHOLATED*NICOTINE		M	HIGH	0.6845	163	-2.48	0.0142	
MENTHOLATED*NICOTINE		M	LOW	0.6817	163	-1.83	0.0686	
MENTHOLATED*NICOTINE		M	SALINE	.	.	.	.	
MENTHOLATED*NICOTINE		N	HIGH	.	.	.	.	
MENTHOLATED*NICOTINE		N	LOW	.	.	.	.	
MENTHOLATED*NICOTINE		N	SALINE	.	.	.	.	
MENTHO*MENTHO*NICOTI	HM	M	HIGH	0.8146	163	-1.08	0.2811	
MENTHO*MENTHO*NICOTI	HM	M	LOW	0.8130	163	-1.09	0.2753	
MENTHO*MENTHO*NICOTI	HM	M	SALINE	.	.	.	.	
MENTHO*MENTHO*NICOTI	HM	N	HIGH	.	.	.	.	
MENTHO*MENTHO*NICOTI	HM	N	LOW	.	.	.	.	
MENTHO*MENTHO*NICOTI	HM	N	SALINE	.	.	.	.	
MENTHO*MENTHO*NICOTI	LM	M	HIGH	0.8135	163	0.97	0.3336	
MENTHO*MENTHO*NICOTI	LM	M	LOW	0.8157	163	1.56	0.1211	
MENTHO*MENTHO*NICOTI	LM	M	SALINE	.	.	.	.	
MENTHO*MENTHO*NICOTI	LM	N	HIGH	.	.	.	.	
MENTHO*MENTHO*NICOTI	LM	N	LOW	.	.	.	.	
MENTHO*MENTHO*NICOTI	LM	N	SALINE	.	.	.	.	
MENTHO*MENTHO*NICOTI	PM	M	HIGH	.	.	.	.	
MENTHO*MENTHO*NICOTI	PM	M	LOW	.	.	.	.	
MENTHO*MENTHO*NICOTI	PM	M	SALINE	.	.	.	.	
MENTHO*MENTHO*NICOTI	PM	N	HIGH	.	.	.	.	
MENTHO*MENTHO*NICOTI	PM	N	LOW	.	.	.	.	
MENTHO*MENTHO*NICOTI	PM	N	SALINE	.	.	.	.	
SESSION				0.1961	163	1.91	0.0573	
SESSION				0.1972	163	-1.37	0.1734	
SESSION				.	.	.	.	
PERIOD				0.1873	163	1.43	0.1554	
PERIOD				0.1822	163	0.51	0.6083	
PERIOD				.	.	.	.	

Type 3 Tests of Fixed Effects	
Effect	Num DF	Den DF	F Value	Pr > F	
MENTHOL	2	85	2.33	0.1039	
MENTHOLATED	1	163	5.27	0.0229	
MENTHOL*MENTHOLATED	2	163	0.41	0.6613	
NICOTINE	2	105	70.30	<.0001	
MENTHOL*NICOTINE	4	163	1.88	0.1163	
MENTHOLATED*NICOTINE	2	163	6.51	0.0019	
MENTHO*MENTHO*NICOTI	4	163	1.99	0.0990	
SESSION	2	163	5.99	0.0031	
PERIOD	2	163	1.05	0.3515	

Estimates	
Label	Estimate	Standard Error	DF	t Value	Pr > |t|	Alpha	Lower	Upper	
Non-mentholated va mentholated at high nicotine	1.8112	0.5292	163	3.42	0.0008	0.05	0.7663	2.8560	
Non-mentholated va mentholated at low nicotine	1.2061	0.5326	163	2.26	0.0248	0.05	0.1545	2.2578	
Non-mentholated va mentholated at saline	0.08347	0.5309	163	0.16	0.8753	0.05	-0.9649	1.1318	

Least Squares Means	
Effect	MENTHOLATED	NICOTINE	SESSION	Estimate	Standard Error	DF	t Value	Pr > |t|	
MENTHOLATED*NICOTINE	M	HIGH		5.0281	0.3522	163	14.28	<.0001	
MENTHOLATED*NICOTINE	M	LOW		3.8159	0.3544	163	10.77	<.0001	
MENTHOLATED*NICOTINE	M	SALINE		3.0070	0.3530	163	8.52	<.0001	
MENTHOLATED*NICOTINE	N	HIGH		6.8392	0.3958	163	17.28	<.0001	
MENTHOLATED*NICOTINE	N	LOW		5.0220	0.3985	163	12.60	<.0001	
MENTHOLATED*NICOTINE	N	SALINE		3.0905	0.3978	163	7.77	<.0001	
SESSION			1	4.8073	0.2431	163	19.78	<.0001	
SESSION			2	4.1622	0.2531	163	16.45	<.0001	
SESSION			3	4.4319	0.2595	163	17.08	<.0001	

Differences of Least Squares Means	
Effect	MENTHOLATED	NICOTINE	SESSION	_MENTHOLATED	_NICOTINE	_SESSION	Estimate	
SESSION			1			2	0.6451	
SESSION			1			3	0.3754	
SESSION			2			3	-0.2697	

Differences of Least Squares Means	
Effect	MENTHOLATED	NICOTINE	SESSION	_MENTHOLATED	_NICOTINE	Standard Error	DF	t Value	
SESSION			1			0.1872	163	3.45	
SESSION			1			0.1961	163	1.91	
SESSION			2			0.1972	163	-1.37	

Differences of Least Squares Means	
Effect	MENTHOLATED	NICOTINE	SESSION	_MENTHOLATED	_NICOTINE	Pr > |t|	
SESSION			1			0.0007	
SESSION			1			0.0573	
SESSION			2			0.1734	

Tests of Effect Slices	
Effect	MENTHOLATED	Num DF	Den DF	F Value	Pr > F	
MENTHOLATED*NICOTINE	M	2	163	19.92	<.0001	
MENTHOLATED*NICOTINE	N	2	163	53.03	<.0001