Yale Radiology and Psychiatry Researchers Join with Penn Medicine to Create a New Center to Study Opioid Use Disorders
Opioid use disorder has reached epidemic levels in the United States. Over the last two decades, opioid-related overdose deaths increased by more than 50 percent, with nearly 50,000 in 2018, according to the Centers for Disease Control and Prevention. Researchers from Yale School of Medicine (YSM) and Penn Medicine, which comprises the Perelman School of Medicine at the University of Pennsylvania, have created a new center that focuses on neuroimaging to improve our understanding of opioid use disorders and find new treatments.
Funding will further study of bipolar disorder in adolescence
The International Bipolar Foundation (IBPF) will fund a project exploring the development of bipolar disorder in adolescence led by Hilary Blumberg, MD, associate professor of psychiatry, in the Child Study Center and of diagnostic radiology. Blumberg is the director of the Mood Disorders Research Program at Yale.
Addicts’ cravings have different roots in men and women
A new brain imaging study by Yale School of Medicine researchers suggests stress robustly activates areas of the brain associated with craving in cocaine-dependent women, while drug cues activate similar brain regions in cocaine-dependent men. The study, expected to be published online Jan. 31 in the American Journal of Psychiatry, suggests men and women with cocaine dependence might benefit more from different treatment options.
Grilo Guest Co-Editor of Special Issue of Clinical Therapeutics
Carlos Grilo, PhD, Professor of Psychiatry and of Psychology and Director of the Yale Program for Obesity Weight and Eating Research, served as guest co-editor on the January 2021 special issue of Clinical Therapeutics, centered on the topic of eating disorders.
Genetic Analysis of Symptoms Yields New Insights Into PTSD
Attempts to identify the genetic causes of neuropsychiatric diseases such as post-traumatic stress disorder (PTSD) through large-scale genome-wide analyses have yielded thousands of potential links. The challenge is further complicated by the wide range of symptoms exhibited by those who have PTSD. For instance, does extreme arousal, anger, or irritation experienced by some have the same genetic basis as the tendency to re-experience traumatic events, another symptom of the disorder? A new study led by researchers at Yale and the University of California-San Diego (UCSD) provides answers to some of these questions and uncovers intriguing genetic similarities between PTSD and other mental health disorders such as anxiety, bipolar disorder, and schizophrenia.Source: Yale News
Scientists Unravel Mystery of Sex Disparities in COVID-19 Outcomes
"Age and sex are where immunological changes intersect,” says Akiko Iwasaki, PhD. Over the past year, Iwasaki and her colleagues from around the globe have compiled a rich literature of research that reveals in detail these and other factors that make the virus more lethal for men.Source: YaleNews
Understanding Immune System Blunders in Response to the Coronavirus
Genetics, gender, and even botched timing on the part of the immune response all appear important in the development of COVID-19. Akiko Iwasaki, PhD, is leading research to help us better predict who is likely to sail through a bout with COVID-19 and who may need targeted lifesaving care.
Childhood Maltreatment and Impact on Clinical Features of Major Depression in Adults
William Prueitt, MD, a second-year resident, is co-author of a paper published in Psychiatry Research that explores the relationship between childhood maltreatment and the clinical features of major depression in adults.Source: Psychiatry Research
Correlates of Homelessness Among Patients in Methadone Maintenance Treatment
Marina Gaeta, a fourth-year Yale School of Medicine student, and Declan Barry, PhD, Associate Professor of Psychiatry, are first and senior authors, respectively, of a paper published in Medical Care that evaluates the correlates of homelessness among patients enrolled in low-barrier-to-treatment-access methadone maintenance treatment programs for opioid use disorder.Source: Medical Care
WHRY Funds Study on How CBD Affects the Brain
Women’s Health Research at Yale announced funding to investigate how the presumably non-intoxicating cannabis ingredient cannabidiol (CBD) affects the brain, and if it affects women and men differently. CBD use is growing in popularity exponentially, yet the safety and effectiveness of this non-regulated category of products are unknown.
Simulation in Addiction Education
In recent years, high-fidelity simulation has proven to be a significantly effective teaching tool in psychiatry and specifically in the treatment of addiction and substance abuse. High-fidelity simulation recreates real-life medical scenarios in a safe learning environment and results in improved medical care and better patient outcomes.Source: Simulation in Addiction Education
Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder
Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural changes in the hippocampus both pre- and post-synaptically, a new study by Yale Psychiatry researchers has found.Source: Molecular Psychiatry
Antipsychotic Medication Prescriptions for Homeless and Unstably Housed Veterans in the VA Health Care System
Jack Tsai, PhD, Associate Professor Adjunct of Psychiatry, and Rajiv Radhakrishnan, MD, Assistant Professor of Psychiatry, are co-authors of a study that examined antipsychotic medication use and correlates of antipsychotic medication prescriptions among homeless and unstably housed veterans.Source: The Journal of Clinical Psychiatry
Why Are Some Scientists Turning Away From Brain Scans?
Joy Hirsch, PhD, Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Comparative Medicine and of Neuroscience, is using an alternative to brain scans to study the "social brain" - what happens when people talk, touch or make eye contact.Source: The Associated Press