2006
GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation
Trotter S, Kapur J, Anzivino M, Lee K. GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation. Journal Of Neuroscience 2006, 26: 10756-10767. PMID: 17050714, PMCID: PMC6674751, DOI: 10.1523/jneurosci.2323-06.2006.Peer-Reviewed Original ResearchConceptsSpontaneous IPSCsSeizure onsetCortical malformationsPyramidal neuronsAmplitude of spontaneous IPSCsFrequency of spontaneous IPSCsCalcium-binding protein parvalbuminGABAergic synaptic inhibitionHeightened seizure susceptibilityInhibitory GABAergic neurotransmissionPresynaptic GABAergic terminalsGABAergic synaptic transmissionResting membrane potentialPyramidal cell somataHigher input resistanceTish cortexMiniature IPSCsNeocortical malformationsSynaptic inhibitionGABAergic interneuronsGABAergic neurotransmissionSeizure susceptibilityProtein parvalbuminImmunohistochemical assessmentGABAergic terminals
2002
Stability of gene expression in postmortem brain revealed by cDNA gene array analysis
Trotter S, Brill L, Bennett J. Stability of gene expression in postmortem brain revealed by cDNA gene array analysis. Brain Research 2002, 942: 120-123. PMID: 12031860, DOI: 10.1016/s0006-8993(02)02644-6.Peer-Reviewed Original ResearchConceptsGene expressionGene expression correlationsStability of gene expressionMeasure gene expressionOvernight refrigerationPostmortem brainsDetect genesExpression correlationPostmortem intervalGene array analysisBrainArray analysisMouse brainBaseline levelsGenesHomogenate pHNylon arraysExpressionCDNA