2004
Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, Staib LH, Charney DS, Bremner JD. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry 2004, 56: 101-112. PMID: 15231442, DOI: 10.1016/j.biopsych.2004.04.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderUrinary free cortisolHippocampal volumeHealthy subjectsMemory deficitsDepressed patientsDepressive disorderCortisol statusSelective serotonin reuptake inhibitor (SSRI) treatmentSerotonin reuptake inhibitor treatmentWechsler Memory Scale-RevisedNormal hippocampal volumesReuptake inhibitor treatmentWhole hippocampal volumeWhole brain volumeDeclarative memory deficitsEffect of treatmentMemory functionDeclarative memory functionUFC excretionAntidepressant treatmentFree cortisolHippocampal dysfunctionBaseline plasmaSuccessful treatment
2002
Reduced volume of orbitofrontal cortex in major depression
Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, Staib LH, Charney DS. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry 2002, 51: 273-279. PMID: 11958777, DOI: 10.1016/s0006-3223(01)01336-1.Peer-Reviewed Original ResearchConceptsMajor depressionOrbitofrontal cortexOrbitofrontal cortical volumeCortical volumeArea 32Area 24Brodmann's area 32Recent postmortem studiesWhole brain volumeSymptoms of depressionBrodmann's area 24Magnetic resonance imagingFrontal cortical regionsFunctional neuroimaging studiesSubcallosal gyrusDepressed patientsPostmortem studiesCortical subregionsComparison subjectsBrain volumePatientsResonance imagingCortical regionsCortexNeuroimaging studies
2000
Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study
Vythilingam M, Anderson E, Goddard A, Woods S, Staib L, Charney D, Bremner J. Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study. Psychiatry Research 2000, 99: 75-82. PMID: 10963983, DOI: 10.1016/s0925-4927(00)00055-x.Peer-Reviewed Original ResearchConceptsTemporal lobe volumePanic disorderTemporal lobeMagnetic resonance imagingControl subjectsHealthy subjectsLobe volumeSmaller temporal lobe volumeNormal hippocampal volumesMagnetic resonance imaging studyHealthy control subjectsRight temporal lobeQuantitative magnetic resonance imaging studyQuantitative MRI measuresWhole brain volumeResonance imaging studyHippocampal volumeBrain changesMRI measuresBrain volumeWhole brainPatientsQualitative abnormalitiesResonance imagingImaging studiesHippocampal Volume Reduction in Major Depression
Bremner J, Narayan M, Anderson E, Staib L, Miller H, Charney D. Hippocampal Volume Reduction in Major Depression. American Journal Of Psychiatry 2000, 157: 115-118. PMID: 10618023, DOI: 10.1176/ajp.157.1.115.Peer-Reviewed Original ResearchConceptsSmaller left hippocampal volumeLeft hippocampal volumeHippocampal volumeMajor depressionComparison subjectsHippocampal volume reductionWhole brain volumeMagnetic resonance imagingNondepressed comparison subjectsAlcohol exposureBrain areasBrain volumeResonance imagingPatientsElevated levelsDepressionHippocampusVolume reductionComparison regionBrain sizeSubjectsRemissionGlucocorticoidsFindings