For Diabetic Patients on Glucophage or Glucovance

Metformin and Iodinated Contrast

How to take your oral diabetes medications containing Metformin after you receive iodinated contrast dye for a CT scan


Diabetes medications that contain Metformin include:

  • Metformin (Glucophage/Glucophage XR, Glumetza, Riomet, Fortamet)
  • Alogliptin/metformin (Kazano)
  • Canagliflozin/metformin (Invokamet/Invokamet XR)
  • Dapagliflozin/metformin (Xigduo XR)
  • Empagliflozin/metformin (Synjardy/Synjardy XR)
  • Ertugliflozin/metformin (Segluromet)
  • Glipizide/metformin (Metaglip)
  • Glyburide/metformin (Glucovance)
  • Linagliptin/metformin (Jentadueto/Jentadueto XR)
  • Pioglitazone/metformin (Actoplus Met/Actoplus Met XR)
  • Repaglinide/metformin (Prandimet)
  • Rosiglitazone/metformin (Avandamet)
  • Saxagliptin/metformin (Kombiglyze XR)
  • Sitagliptin/metformin (Janumet/Janumet XR)
  • Vildagliptin/metformin (Eucreas)

Why should I be taking my metformin differently?
  • In rare instances, Metformin can cause a severe side effect called lactic acidosis. This may occur more frequently in patients with decreased kidney function. Decreased kidney function is apparent when your estimated glomerular filtration rate (eGFR) is less than 30 mL/min. Contrast dye can increase the chances of metformin causing lactic acidosis in patients with decreased kidney function.

What should I do?
  • If you have decreased kidney function (eGFR less than 30 mL/min):
    • Stop taking metformin or metformin-containing products and contact your doctor within 48 hours before restarting.
    • Bring this form with you to the doctor.

  • If you do not have decreased kidney function (eGFR 30 mL/min or greater):
    • Continue taking metformin as originally prescribed.

Questions or concerns
  • If you have any questions or concerns, talk to your doctor or pharmacist.