2010
Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis
Tandon P, Inayat I, Tal M, Spector M, Shea M, Groszmann RJ, Garcia–Tsao G. Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis. Clinical Gastroenterology And Hepatology 2010, 8: 546-549. PMID: 20144739, PMCID: PMC2879450, DOI: 10.1016/j.cgh.2010.01.017.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientMean arterial pressurePortal pressureArterial pressureHeart rateBaseline hepatic venous pressure gradientMedian mean arterial pressureOpen-label pilot studyPhosphodiesterase-5 inhibitor sildenafilSystemic vasodilatory effectVenous pressure gradientEffect of sildenafilPortal venous inflowIntrahepatic resistanceOral sildenafilCompensated cirrhosisCirrhotic patientsVasodilatory effectChild APortal hemodynamicsErectile dysfunctionVenous inflowInhibitor sildenafilTherapeutic dosesPatients
1997
Further evidence in favor of pharmacological portal pressure reduction in the prevention of variceal hemorrhage
García-Tsao G. Further evidence in favor of pharmacological portal pressure reduction in the prevention of variceal hemorrhage. Gastroenterology 1997, 112: 1770-1771. PMID: 9136864, DOI: 10.1016/s0016-5085(97)70067-2.Peer-Reviewed Original Research
1995
Cirrhotic ascites: pathogenesis and management.
Garcia-Tsao G. Cirrhotic ascites: pathogenesis and management. The Gastroenterologist 1995, 3: 41-54. PMID: 7743121.BooksConceptsPathogenesis of ascitesComplications of cirrhosisNegative sodium balanceAccumulation of fluidSinusoidal hypertensionLiver transplantationSalt restrictionPortosystemic shuntingPeripheral vasoconstrictorNonsurgical sideIntravascular volumeCurrent therapiesIntraperitoneal fluidSodium balanceTherapeutic priorityTherapeutic measuresPeritoneal spacePeritoneal cavitySystemic circulationAscitesEfflux of fluidPatientsDiureticsPathogenesisFuture studies