2022
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease
Ventura-Cots M, Argemi J, Jones PD, Lackner C, Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez-Pinto H, Costa A, Degré D, Fernandez-Carrillo C, Ganne-Carrie N, Garcia-Tsao G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez-Sanchez N, Miquel R, Moreno C, Mounajjed T, Odena G, Kim W, Sancho-Bru P, Sands R, Szafranska J, Verset L, Schnabl B, Sempoux C, Shah V, Shawcross DL, Stauber RE, Straub BK, Verna E, Tiniakos D, Trépo E, Vargas V, Villanueva C, Woosley JT, Ziol M, Mueller S, Stärkel P, Bataller R. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease. Gut 2022, 71: 1856-1866. PMID: 34992134, PMCID: PMC11034788, DOI: 10.1136/gutjnl-2021-324295.Peer-Reviewed Original ResearchConceptsAlcohol-related liver diseaseAlcohol-related hepatitisAH patientsLiver diseaseAlcohol intakeDuctular reactionGamma-glutamyl transferase levelsProfound liver failureSevere neutrophil infiltrationWorse liver functionObservational multicentre studyOne-year mortalityBile acid metabolismMallory-Denk bodiesRNA microarray analysisNeutrophil infiltrationProspective cohortRetrospective cohortAdvanced fibrosisLiver failureMulticentre studySteatosis gradeLiver functionPericellular fibrosisSevere fibrosis
2021
Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death
Chew M, Tang Z, Radcliffe C, Caruana D, Doilicho N, Ciarleglio MM, Deng Y, Garcia-Tsao G. Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death. Clinical Gastroenterology And Hepatology 2021, 19: 2182-2191.e7. PMID: 34004326, PMCID: PMC8123528, DOI: 10.1016/j.cgh.2021.05.022.Peer-Reviewed Original ResearchConceptsSignificant liver injuryLiver injuryLiver insufficiencyCOVID-19High-sensitivity C-reactive protein valuesC-reactive protein valuesDrug-induced liver injuryHepatocellular liver injuryInternational normalized ratioMultivariate logistic regressionHyperinflammatory stateTocilizumab useVasopressor useConcomitant medicationsConsecutive patientsIndependent predictorsLiver failureBilirubin levelsD-dimerTest abnormalitiesNormalized ratioAlanine aminotransferaseHospitalizationPatientsInjury
2020
Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis
Bajaj JS, Reddy KR, O'Leary JG, Vargas HE, Lai JC, Kamath PS, Tandon P, Wong F, Subramanian RM, Thuluvath P, Fagan A, White MB, Gavis EA, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Sikaroodi M, Garcia-Tsao G, Gillevet PM. Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis. Gastroenterology 2020, 159: 1715-1730.e12. PMID: 32687928, PMCID: PMC7680282, DOI: 10.1053/j.gastro.2020.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAcute-On-Chronic Liver FailureAdultAgedBacteriaBiomarkersDatabases, FactualFecesFemaleGastrointestinal MicrobiomeHospital MortalityHumansLipidomicsLipidsLiver CirrhosisMaleMetabolomicsMiddle AgedNorth AmericaPatient AdmissionPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsTime FactorsConceptsDevelopment of ACLFSerum levelsClinical parametersStool samplesSerum metabolitesEnd-stage liver diseaseWhite blood cell countSerum samplesFecal microbiomeTertiary hepatology centersChronic liver failureDay of admissionMultiple centersTime of admissionBlood cell countNorth American ConsortiumLevels of phospholipidsMetabolomic analysisHepatology centersHospital admissionLiver failureClinical featuresLiver diseaseACLFEstrogen metabolites
2019
Impact of Chronic Kidney Disease on Outcomes in Cirrhosis
Wong F, Reddy K, O’Leary J, Tandon P, Biggins SW, Garcia‐Tsao G, Maliakkal BJ, Lai JC, Fallon MB, Vargas HE, Subramanian R, Thuluvath PJ, Kamath PS, Thacker L, Bajaj JS. Impact of Chronic Kidney Disease on Outcomes in Cirrhosis. Liver Transplantation 2019, 25: 870-880. PMID: 30908855, PMCID: PMC11075743, DOI: 10.1002/lt.25454.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseasePrevalence of CKDEnd-stage liver diseaseHospital clinical courseAcute kidney injuryChild-Pugh scoreChronic liver failureHigher serum creatinineGlomerular filtration rateHigh-risk groupNorth American ConsortiumCKD groupHospital courseKidney injuryRefractory ascitesNegative patientsOverall survivalPositive patientsSerum creatinineCirrhosis etiologyClinical courseHospital admissionHospitalized patientsLiver failure573 – Predictive Factors for the Development of Acute-Onchronic Liver Failure in a North American Cohort of Hospitalized Cirrhotic Patients with Decompensation
Wong F, Reddy K, Tandon P, O'Leary J, Garcia-Tsao G, Lai J, Vargas H, Biggins S, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath P, Thacker L, Bajaj J. 573 – Predictive Factors for the Development of Acute-Onchronic Liver Failure in a North American Cohort of Hospitalized Cirrhotic Patients with Decompensation. Gastroenterology 2019, 156: s-1205. DOI: 10.1016/s0016-5085(19)39995-0.Peer-Reviewed Original ResearchOutcomes After Listing for Liver Transplant in Patients With Acute‐on‐Chronic Liver Failure: The Multicenter North American Consortium for the Study of End‐Stage Liver Disease Experience
O’Leary J, Bajaj JS, Tandon P, Biggins SW, Wong F, Kamath PS, Garcia‐Tsao G, Maliakkal B, Lai J, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Reddy K. Outcomes After Listing for Liver Transplant in Patients With Acute‐on‐Chronic Liver Failure: The Multicenter North American Consortium for the Study of End‐Stage Liver Disease Experience. Liver Transplantation 2019, 25: 571-579. PMID: 30724010, PMCID: PMC11075742, DOI: 10.1002/lt.25426.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-On-Chronic Liver FailureAdultDisease ProgressionEnd Stage Liver DiseaseFemaleHospital MortalityHospitalizationHumansLiver CirrhosisLiver TransplantationMaleMiddle AgedNorth AmericaProspective StudiesRenal DialysisSeverity of Illness IndexSurvival RateTime-to-TreatmentWaiting ListsConceptsChronic liver failureLiver transplantationNorth American ConsortiumLiver failureEnd-stage liver disease (MELD) scoreEnd-stage liver diseaseAmerican ConsortiumExtrahepatic organ failureAcute kidney injuryLiver Disease scoreOutcomes of patientsPost-LT survivalPerioperative dialysisRenal recoveryKidney injuryLiver transplantOrgan failureLiver diseaseMedian timeMedian MELDACLFSimilar survivalDisease experienceDisease scorePatientsSAT-139-Predictive factors for the development of acute-on-chronic liver failure in a North American cohort of hospitalized patients with cirrhosis and decompensation
Wong F, Reddy R, Tandon P, O’leary J, Garcia-Tsao G, Lai J, Vargas H, Biggins S, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath P, Thacker L, Bajaj J. SAT-139-Predictive factors for the development of acute-on-chronic liver failure in a North American cohort of hospitalized patients with cirrhosis and decompensation. Journal Of Hepatology 2019, 70: e691-e692. DOI: 10.1016/s0618-8278(19)31378-7.Peer-Reviewed Original Research
2018
Acute‐on‐Chronic Liver Failure: An Old Entity in Search of Clarity
Garcia‐Tsao G. Acute‐on‐Chronic Liver Failure: An Old Entity in Search of Clarity. Hepatology Communications 2018, 2: 1421-1424. PMID: 30556031, PMCID: PMC6287486, DOI: 10.1002/hep4.1287.Commentaries, Editorials and Letters
2017
Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta‐analysis
Albillos A, Zamora J, Martínez J, Arroyo D, Ahmad I, De‐la‐Peña J, Garcia‐Pagán J, Lo G, Sarin S, Sharma B, Abraldes JG, Bosch J, Garcia‐Tsao G, Cooperation O. Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta‐analysis. Hepatology 2017, 66: 1219-1231. PMID: 28543862, PMCID: PMC5605404, DOI: 10.1002/hep.29267.Peer-Reviewed Original ResearchConceptsChild B/CPrevious variceal bleedingCombination therapyVariceal bleedingCirrhosis severityChild APrognostic stageRecurrent variceal hemorrhageAdvanced liver failureEndoscopic variceal ligationOutcome of therapyVariceal hemorrhageLiver failureVariceal ligationLiver functionPatientsPatient careVaricealTherapyPatient dataMortalityTrialsCirrhosisBleedingProphylaxis421 Nacseld Acute-on-Chronic Liver Failure (NACSELD-ACLF) Predicts 30-Day Mortality in Admitted Cirrhotic Patients
O'Leary J, Reddy K, Tandon P, Kamath P, Wong F, Garcia-Tsao G, Lai J, Biggins S, Fallon M, Subramanian R, Thuluvath P, Maliakkal B, Thacker L, Bajaj J. 421 Nacseld Acute-on-Chronic Liver Failure (NACSELD-ACLF) Predicts 30-Day Mortality in Admitted Cirrhotic Patients. Gastroenterology 2017, 152: s1056-s1057. DOI: 10.1016/s0016-5085(17)33569-2.Peer-Reviewed Original Research
2015
Natural History of Cirrhosis
Garcia-Tsao G. Natural History of Cirrhosis. 2015, 13-20. DOI: 10.1007/978-3-319-13614-1_2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrognostic stageHepatic venous pressure gradientNatural historyDifferent prognostic stagesRecurrent variceal hemorrhageVenous pressure gradientMulti-organ failureAbsence of varicesHepatorenal syndromeDecompensated cirrhosisRefractory ascitesVariceal hemorrhageHepatic encephalopathyLiver failureSpecific complicationsWorse prognosisDecompensated stageReversible diseaseCirrhosisPatientsVaricesPrognosisDecompensationAscitesComplicationsP0119 : Validation Of The NACSELD Infection-Related Acute-on-Chronic Liver Failure (I-ACLF) score in an independent multicenter cohort
O’Leary J, Reddy K, Garcia-Tsao G, Biggins S, Wong F, Fallon M, Subramanian R, Kamath P, Thuluvath P, Maliakkal B, Patton H, Tandon P, Thacker L, Bajaj J, behalf of NACSESLD. O. P0119 : Validation Of The NACSELD Infection-Related Acute-on-Chronic Liver Failure (I-ACLF) score in an independent multicenter cohort. Journal Of Hepatology 2015, 62: s345. DOI: 10.1016/s0168-8278(15)30339-1.Peer-Reviewed Original Research
2014
Survival in infection‐related acute‐on‐chronic liver failure is defined by extrahepatic organ failures
Bajaj JS, O'Leary JG, Reddy KR, Wong F, Biggins SW, Patton H, Fallon MB, Garcia‐Tsao G, Maliakkal B, Malik R, Subramanian RM, Thacker LR, Kamath PS, Disease T. Survival in infection‐related acute‐on‐chronic liver failure is defined by extrahepatic organ failures. Hepatology 2014, 60: 250-256. PMID: 24677131, PMCID: PMC4077926, DOI: 10.1002/hep.27077.Peer-Reviewed Original ResearchConceptsMean arterial pressureLower mean arterial pressureExtrahepatic organ failureChronic liver failureSpontaneous bacterial peritonitisUrinary tract infectionOrgan failureCirrhosis patientsHepatic encephalopathyIndependent predictorsLiver failureSecond infectionEndstage Liver Disease (MELD) scoreHigher white blood countBaseline independent predictorsDevelopment of ACLFNon-SBP infectionsLiver Disease scoreMore organ failuresWhite blood countNorth American ConsortiumDeterminants of survivalRenal replacementTract infectionsArterial pressure
2010
Antibiotic Prophylaxis and Management of Bacterial Infections
Lim J, Tandon P, Garcia-Tsao G. Antibiotic Prophylaxis and Management of Bacterial Infections. Clinical Gastroenterology 2010, 395-410. DOI: 10.1007/978-1-60761-866-9_20.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSpontaneous bacterial peritonitisBacterial infectionsAntibiotic prophylaxisAcute kidney injuryRecurrent variceal hemorrhageHigh-risk patientsRole of antibioticsAcute decompensationKidney injuryVariceal hemorrhageBacterial peritonitisImportant complicationLiver failureClinical featuresCommon infectionsRisk factorsRole of albuminCirrhosisCommon precipitantsProphylaxisInfectionCommon typePatientsDecompensationPeritonitis
1994
A Comparative Clinical Study of Idiopathic Portal Hypertension, Extrahepatic Portal Vein Thrombosis, and Cirrhosis
Orozco H, Takahashi T, Garcia-Tsao G, Mercado M, Prado E, Nava R. A Comparative Clinical Study of Idiopathic Portal Hypertension, Extrahepatic Portal Vein Thrombosis, and Cirrhosis. Journal Of Clinical Gastroenterology 1994, 19: 217-221. PMID: 7806833, DOI: 10.1097/00004836-199410000-00010.Peer-Reviewed Original ResearchConceptsExtrahepatic portal vein thrombosisIdiopathic portal hypertensionPortal vein thrombosisLiver cirrhosisPortal hypertensionVein thrombosisClinical featuresLC patientsComparative clinical studySeparate clinical entityLiver failureLaboratory variablesClinical entityRetrospective studyClinical studiesPatientsStatistical differenceHypertensionCirrhosisThrombosisHigher proportionSurvivalSimilar distributionGroup
1991
Idiopathic portal hypertension.
Orozco H, Takahashi T, García-Tsao G, Mercado M, Diliz H, Hernández-Ortiz J. Idiopathic portal hypertension. Revista De Investigación Clínica 1991, 43: 80-6. PMID: 1866503.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIdiopathic portal hypertensionPortal hypertensionHigh re-bleeding rateMain histopathologic findingsNoncirrhotic portal fibrosisObliterative portal venopathySmall portal veinsRe-bleeding rateIntra-abdominal infectionsLong-term prognosisUpper gastrointestinal tractHepatitis B virusEsophago-gastric varicesChronic sclerotherapyHepatoportal sclerosisIPH patientsPortal venopathyPharmacologic managementVariceal bleedingCirrhotic patientsImmunologic abnormalitiesPortal fibrosisLiver failurePeriportal fibrosisSuch patients