2020
Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis
Lang S, Duan Y, Liu J, Torralba MG, Kuelbs C, Ventura‐Cots M, Abraldes JG, Bosques‐Padilla F, Verna EC, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross D, Lucey MR, Louvet A, Mathurin P, Garcia‐Tsao G, Ho SB, Tu XM, Bataller R, Stärkel P, Fouts DE, Schnabl B. Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis. Hepatology 2020, 71: 522-538. PMID: 31228214, PMCID: PMC6925657, DOI: 10.1002/hep.30832.Peer-Reviewed Original ResearchConceptsAnti-Saccharomyces cerevisiae antibodiesSerum anti-Saccharomyces cerevisiae antibodiesAlcoholic hepatitisSystemic immune responsesAlcohol use disorderASCA levelsLiver diseaseNonalcoholic controlsImmune responseUse disordersAlcohol-associated liver diseaseAlcohol-related liver diseaseHigher ASCA levelsIntestinal Fungal DysbiosisOvergrowth of CandidaAdjusted hazard ratioCohort of patientsChronic alcohol consumptionIntestinal microbiota compositionIU/mLCerevisiae antibodiesFecal mycobiotaHepatitis cohortHazard ratioSteroid treatment
2019
246 – Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients with Alcoholic Hepatitis
Lang S, Duan Y, Liu J, Ventura-Cots M, Lucey M, Padilla F, Mathurin P, Louvet A, Garcia-Tsao G, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Ho S, Bataller R, Tu X, Stärkel P, Fouts D, Schnabl B. 246 – Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients with Alcoholic Hepatitis. Gastroenterology 2019, 156: s-1186. DOI: 10.1016/s0016-5085(19)39939-1.Peer-Reviewed Original Research
2005
Bacterial translocation (BT) in cirrhosis
Wiest R, Garcia‐Tsao G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005, 41: 422-433. PMID: 15723320, DOI: 10.1002/hep.20632.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsComplications of cirrhosisBacterial translocationPrevention of BTMucosal barrier functionAdaptive immune responsesPrevention of infectionNew therapeutic targetsImmunological defense mechanismsHuman cirrhosisIntestinal pathophysiologyCirrhosisImmune responseTherapeutic approachesIntestinal floraTherapeutic targetAnatomical sitesGut floraBarrier functionComplicationsMultiple mechanismsPathogenesisPreventionCurrent knowledgeDefense mechanismsAlterations