Zenta Walther, MD, PhD
Associate Professor of Pathology; Director, Molecular Genetic Pathology Fellowship Program
Research & Publications
Biography
Locations
Coauthors
Selected Publications
- Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung CancerStockhammer P, Grant M, Wurtz A, Foggetti G, Expósito F, Gu J, Zhao H, Choi J, Chung S, Li F, Walther Z, Dietz J, Duffield E, Gettinger S, Politi K, Goldberg S. Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer. Journal Of Thoracic Oncology 2023, 19: 240-251. PMID: 37806385, DOI: 10.1016/j.jtho.2023.10.001.
- Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All “BRCAness” Is Created EqualDoroshow D, Wei W, Mehrotra M, Sia D, Eder J, Bindra R, Houldsworth J, LoRusso P, Walther Z. Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All “BRCAness” Is Created Equal. Cancer Investigation 2023, 41: 646-655. PMID: 37505929, DOI: 10.1080/07357907.2023.2242957.
- NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) Plus Intravenous Irinotecan Administered in Patients with Advanced Solid TumorsCecchini M, Walther Z, Wei W, Hafez N, Pilat M, Boerner S, Durecki D, Eder J, Schalper K, Chen A, LoRusso P. NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) Plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors. Cancer Research Communications 2023, 3: 1113-1117. PMID: 37377610, PMCID: PMC10292219, DOI: 10.1158/2767-9764.crc-22-0485.
- Relations between mutant KRAS and TP53 subtypes and other co-mutations in pancreatic cancer.Abraham S, Zhang J, Walther Z, Parekh J, Lacy J, Cecchini M, Hu Y. Relations between mutant KRAS and TP53 subtypes and other co-mutations in pancreatic cancer. Journal Of Clinical Oncology 2023, 41: e16294-e16294. DOI: 10.1200/jco.2023.41.16_suppl.e16294.
- Association of alterations in multiple tumor suppressor genes with poor outcomes in patients with EGFR-mutant lung cancer.Stockhammer P, Grant M, Wurtz A, Foggetti G, Expósito F, Gu J, Chung S, Li F, Walther Z, Gettinger S, Politi K, Goldberg S. Association of alterations in multiple tumor suppressor genes with poor outcomes in patients with EGFR-mutant lung cancer. Journal Of Clinical Oncology 2023, 41: 9104-9104. DOI: 10.1200/jco.2023.41.16_suppl.9104.
- Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion MutationsGrant M, Aredo J, Starrett J, Stockhammer P, K. Rosenburgh I, Wurtz A, Piper-Valillo A, Piotrowska Z, Falcon C, Yu H, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li F, Neal J, Lemmon M, Walther Z, Politi K, Goldberg S. Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations. Clinical Cancer Research 2023, 29: of1-of8. PMID: 36913537, PMCID: PMC10493186, DOI: 10.1158/1078-0432.ccr-22-3497.
- Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutationsvan Alderwerelt van Rosenburgh I, Lu D, Grant M, Stayrook S, Phadke M, Walther Z, Goldberg S, Politi K, Lemmon M, Ashtekar K, Tsutsui Y. Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nature Communications 2022, 13: 6791. PMID: 36357385, PMCID: PMC9649653, DOI: 10.1038/s41467-022-34398-z.
- Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI-Treated Patients with EGFR-Mutant NSCLC (SWOG S1403).Mack PC, Miao J, Redman MW, Moon J, Goldberg SB, Herbst RS, Melnick MA, Walther Z, Hirsch FR, Politi K, Kelly K, Gandara DR. Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI-Treated Patients with EGFR-Mutant NSCLC (SWOG S1403). Clinical Cancer Research 2022, 28: 3752-3760. PMID: 35713632, PMCID: PMC9444942, DOI: 10.1158/1078-0432.ccr-22-0741.
- An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center.Wang JD, Sebastian C, Walther Z, Suresh T, Lacy J, Zhang X, Jain D. An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center. Archives Of Pathology & Laboratory Medicine 2022, 147: 185-192. PMID: 35512224, DOI: 10.5858/arpa.2021-0457-oa.
- Comprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimensRazzano D, Bouza SJ, Hernandez PV, Wang M, Robert ME, Walther Z, Cai G. Comprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimens. Cancer Cytopathology 2022, 130: 726-734. PMID: 35511415, DOI: 10.1002/cncy.22589.
- Yale Precision Medicine Tumor Board: reawakening the guardian of the genomeGrant MJ, Finberg KE, Walther Z, Stein SM, Lacy J, Eder JP, Goldberg SB. Yale Precision Medicine Tumor Board: reawakening the guardian of the genome. The Lancet Oncology 2022, 23: 337-338. PMID: 35240081, DOI: 10.1016/s1470-2045(22)00037-7.
- Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinomaLi H, Zhang X, Finberg KE, Walther Z, Jain D, Gibson J. Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma. Pathology International 2021, 72: 138-140. PMID: 34808016, DOI: 10.1111/pin.13188.
- Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmationLi P, Barbieri A, Walther Z, McNiff J, Panse G. Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation. Journal Of Cutaneous Pathology 2021, 48: 1514-1519. PMID: 34302376, DOI: 10.1111/cup.14108.
- Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment planGibson JA, Finberg KE, Nalbantoglu I, Cecchini M, Ganzak A, Walther Z, Sklar JL, Eder JP, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan. The Lancet Oncology 2021, 22: 306-307. PMID: 33662283, DOI: 10.1016/s1470-2045(20)30683-5.
- Yale Cancer Center Precision Medicine Tumor Board: new technology, new drugs, and the value of repeat testingHafez N, Walther Z, Eder JP, Sklar JL, Gettinger SN, Finberg KE, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: new technology, new drugs, and the value of repeat testing. The Lancet Oncology 2020, 21: 343-344. PMID: 32950226, DOI: 10.1016/s1470-2045(20)30010-3.
- The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung AdenocarcinomaTruini A, Starrett JH, Stewart T, Ashtekar K, Walther Z, Wurtz A, Lu D, Park JH, DeVeaux M, Song X, Gettinger S, Zelterman D, Lemmon MA, Goldberg SB, Politi K. The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma. Clinical Cancer Research 2019, 25: 6382-6391. PMID: 31182434, PMCID: PMC6825535, DOI: 10.1158/1078-0432.ccr-19-0780.
- Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humansDubey JP, Evason KJ, Walther Z. Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humans. Parasitology 2019, 146: 865-872. PMID: 30859916, DOI: 10.1017/s003118201900012x.
- Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasmCharifa A, Walther Z, Salem R, Jain D. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm. Human Pathology Reports 2019, 15: 95-98. DOI: 10.1016/j.ehpc.2018.12.007.
- Yale Cancer Center Precision Medicine Tumor Board: one tumour, multiple targetsStewart T, Finberg K, Walther Z, Sklar JL, Hafez N, Eder JP, Anderson K, Wilson F, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: one tumour, multiple targets. The Lancet Oncology 2018, 19: 1567-1568. PMID: 32956641, DOI: 10.1016/s1470-2045(18)30759-9.
- Yale Cancer Center Precision Medicine Tumor Board: two patients, one targeted therapy, different outcomesCecchini M, Walther Z, Sklar JL, Bindra RS, Petrylak DP, Eder JP, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: two patients, one targeted therapy, different outcomes. The Lancet Oncology 2018, 19: 23-24. PMID: 29304353, DOI: 10.1016/s1470-2045(17)30916-6.
- Introduction to the Yale Precision Medicine Tumor BoardCecchini M, Walther Z, Sklar JL, Bindra RS, Petrylak DP, Eder JP, Goldberg SB. Introduction to the Yale Precision Medicine Tumor Board. The Lancet Oncology 2018, 19: 19-20. PMID: 29304351, DOI: 10.1016/s1470-2045(17)30919-1.
- Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial Molecular Analysis for Therapy Choice Clinical TrialLih CJ, Harrington RD, Sims DJ, Harper KN, Bouk CH, Datta V, Yau J, Singh RR, Routbort MJ, Luthra R, Patel KP, Mantha GS, Krishnamurthy S, Ronski K, Walther Z, Finberg KE, Canosa S, Robinson H, Raymond A, Le LP, McShane LM, Polley EC, Conley BA, Doroshow JH, Iafrate AJ, Sklar JL, Hamilton SR, Williams PM. Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial Molecular Analysis for Therapy Choice Clinical Trial. Journal Of Molecular Diagnostics 2017, 19: 313-327. PMID: 28188106, PMCID: PMC5397672, DOI: 10.1016/j.jmoldx.2016.10.007.
- A Long-Term Survivor of Metastatic Pancreatic Adenocarcinoma: Free of Recurrence 12 Years After Treatment of Oligometastatic DiseaseStahl JM, Walther Z, Chang BW, Hochster HS, Johung KL. A Long-Term Survivor of Metastatic Pancreatic Adenocarcinoma: Free of Recurrence 12 Years After Treatment of Oligometastatic Disease. Cureus 2017, 9: e1007. PMID: 28293485, PMCID: PMC5333949, DOI: 10.7759/cureus.1007.
- Congenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) With Associated Hepatocellular CarcinomaBenedict M, Rodriguez-Davalos M, Emre S, Walther Z, Morotti R. Congenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) With Associated Hepatocellular Carcinoma. Pediatric And Developmental Pathology 2017, 20: 354-362. PMID: 28727971, DOI: 10.1177/1093526616686458.
- Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1Pirazzoli V, Nebhan C, Song X, Wurtz A, Walther Z, Cai G, Zhao Z, Jia P, de Stanchina E, Shapiro EM, Gale M, Yin R, Horn L, Carbone DP, Stephens PJ, Miller V, Gettinger S, Pao W, Politi K. Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1. Cell Reports 2014, 7: 999-1008. PMID: 24813888, PMCID: PMC4074596, DOI: 10.1016/j.celrep.2014.04.014.
- Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancerde Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, Varmus H, Bernards R, Smit EF, Politi K, Downward J. Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer. Cancer Discovery 2014, 4: 606-619. PMID: 24535670, PMCID: PMC4011693, DOI: 10.1158/2159-8290.cd-13-0741.
- MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient miceHoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, Medzhitov R. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nature Communications 2012, 3: 1120. PMID: 23047678, PMCID: PMC3521499, DOI: 10.1038/ncomms2113.
- Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APCMin/+ MiceWoo DK, Green PD, Santos JH, D'Souza AD, Walther Z, Martin WD, Christian BE, Chandel NS, Shadel GS. Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APCMin/+ Mice. American Journal Of Pathology 2011, 180: 24-31. PMID: 22056359, PMCID: PMC3338350, DOI: 10.1016/j.ajpath.2011.10.003.
- Molecular Pathology of Hepatic Neoplasms: Classification and Clinical SignificanceWalther Z, Jain D. Molecular Pathology of Hepatic Neoplasms: Classification and Clinical Significance. Pathology Research International 2011, 2011: 403929. PMID: 21559202, PMCID: PMC3090128, DOI: 10.4061/2011/403929.
- Molecular Tumor Profiling for Prediction of Response to Anticancer TherapiesWalther Z, Sklar J. Molecular Tumor Profiling for Prediction of Response to Anticancer Therapies. The Cancer Journal 2011, 17: 71-79. PMID: 21427550, DOI: 10.1097/ppo.0b013e318212dd6d.
- CASK Deletion in Intestinal Epithelia Causes Mislocalization of LIN7C and the DLG1/Scrib Polarity Complex without Affecting Cell PolarityLozovatsky L, Abayasekara N, Piawah S, Walther Z. CASK Deletion in Intestinal Epithelia Causes Mislocalization of LIN7C and the DLG1/Scrib Polarity Complex without Affecting Cell Polarity. Molecular Biology Of The Cell 2009, 20: 4489-4499. PMID: 19726564, PMCID: PMC2770937, DOI: 10.1091/mbc.e09-04-0280.
- Isospora cholangiopathy: case study with histologic characterization and molecular confirmationWalther Z, Topazian MD. Isospora cholangiopathy: case study with histologic characterization and molecular confirmation. Human Pathology 2009, 40: 1342-1346. PMID: 19447468, DOI: 10.1016/j.humpath.2009.01.020.
- A PDZ‐Binding Motif Controls Basolateral Targeting of Syndecan‐1 Along the Biosynthetic Pathway in Polarized Epithelial CellsMaday S, Anderson E, Chang HC, Shorter J, Satoh A, Sfakianos J, Fölsch H, Anderson JM, Walther Z, Mellman I. A PDZ‐Binding Motif Controls Basolateral Targeting of Syndecan‐1 Along the Biosynthetic Pathway in Polarized Epithelial Cells. Traffic 2008, 9: 1915-1924. PMID: 18764819, PMCID: PMC2820280, DOI: 10.1111/j.1600-0854.2008.00805.x.
- The Unique-5 and -6 Motifs of ZO-1 Regulate Tight Junction Strand Localization and Scaffolding PropertiesFanning AS, Little BP, Rahner C, Utepbergenov D, Walther Z, Anderson JM. The Unique-5 and -6 Motifs of ZO-1 Regulate Tight Junction Strand Localization and Scaffolding Properties. Molecular Biology Of The Cell 2006, 18: 721-731. PMID: 17182847, PMCID: PMC1805089, DOI: 10.1091/mbc.e06-08-0764.
- Ileostomy Adenocarcinomas in the Setting of Ulcerative ColitisAchneck HE, Wong IY, Kim PJ, Fernandes MA, Walther Z, Seymour NE, Jain D. Ileostomy Adenocarcinomas in the Setting of Ulcerative Colitis. Journal Of Clinical Gastroenterology 2005, 39: 396-400. PMID: 15815208, DOI: 10.1097/01.mcg.0000159216.39795.4a.
- hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions*Nix S, Chishti A, Anderson J, Walther Z. hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions*. Journal Of Biological Chemistry 2000, 275: 41192-41200. PMID: 10993877, DOI: 10.1074/jbc.m002078200.
- Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial CellsCohen A, Wood D, Marfatia S, Walther Z, Chishti A, Anderson J. Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells. Journal Of Cell Biology 1998, 142: 129-138. PMID: 9660868, PMCID: PMC2133028, DOI: 10.1083/jcb.142.1.129.
- The kinesin-homologous protein encoded by the Chlamydomonas FLA10 gene is associated with basal bodies and centriolesVashishtha M, Walther Z, Hall J. The kinesin-homologous protein encoded by the Chlamydomonas FLA10 gene is associated with basal bodies and centrioles. Journal Of Cell Science 1996, 109: 541-549. PMID: 8907700, DOI: 10.1242/jcs.109.3.541.
- The uni chromosome of Chlamydomonas: histone genes and nucleosome structureWalther Z, Hall J. The uni chromosome of Chlamydomonas: histone genes and nucleosome structure. Nucleic Acids Research 1995, 23: 3756-3763. PMID: 7479007, PMCID: PMC307276, DOI: 10.1093/nar/23.18.3756.
- The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein.Walther Z, Vashishtha M, Hall JL. The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein. Journal Of Cell Biology 1994, 126: 175-188. PMID: 8027176, PMCID: PMC2120091, DOI: 10.1083/jcb.126.1.175.
- slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous systemRothberg J, Hartley D, Walther Z, Artavanis-Tsakonas S. slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell 1988, 55: 1047-1059. PMID: 3144436, DOI: 10.1016/0092-8674(88)90249-8.
- Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.Walther Z, May LT, Sehgal PB. Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. The Journal Of Immunology 1988, 140: 974-7. PMID: 3276786, DOI: 10.4049/jimmunol.140.3.974.
- Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187.Sehgal PB, Walther Z, Tamm I. Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 3663-3667. PMID: 3108877, PMCID: PMC304935, DOI: 10.1073/pnas.84.11.3663.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Lung | Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer |