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Romina Fiorotto, PhD

Assistant Professor of Medicine (Digestive Diseases) and of Pathology; Associate Director, Cellular & Molecular Physiology Core

Research & Publications
Biography
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Research Summary

Dr. Fiorotto’s research is focused on understanding the basic pathophysiological mechanisms of diseases of the biliary tree, with a long-term goal of developing innovative and more efficient therapeutic alternatives.

During the past several years, she has focused on the Cystic Fibrosis related liver disease (CFLD). This genetic disease of secretory epithelia may develop a form of fibrotic cholangitis that compromise patient’s survival and quality of life. Her studies uncovered the role of Toll-like receptors and epithelial innate immunity in the pathogenesis of CFLD. Currently she is exploring the complex interplay between genetic susceptibility of the biliary epithelium and the causal role of the gut microbiota in the development and progression of CFLD. Dr. Fiorotto is using several mouse models to perform analysis of the gut microbiota and to establish in vitro cultures of cholangiocytes.

In addition, Dr. Fiorotto has contributed to the generation of polarized cultures of cholangiocytes from patients using the cutting-edge technology of induced pluripotent stem cells (iPSC). She is now combining this technology with 3D culture of liver organoids to model in vitroa number of human biliary diseases and to test personalized therapeutic approaches.

Coauthors

Selected Publications

FRI-358 scRNA transcriptomics reveal the role of cholangiocytes and neutrophils cross talk in PKHD1-KO miceSyeda Z, Fiorotto R, Taleb S, Bauer-Pisani T, Zhao D, Strazzabosco M. FRI-358 scRNA transcriptomics reveal the role of cholangiocytes and neutrophils cross talk in PKHD1-KO mice. Journal Of Hepatology 2023, 78: s423. DOI: 10.1016/s0168-8278(23)01099-1.
Fibroblasts to hepatocytes: A nonstop flight into cell therapy for liver diseases?Gouon‐Evans V, Fiorotto R. Fibroblasts to hepatocytes: A nonstop flight into cell therapy for liver diseases? Hepatology 2023, 77: 1469-1471. PMID: 35957526, DOI: 10.1002/hep.32725.
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiationFiorotto R, Mariotti V, Taleb S, Zehra S, Nguyen M, Amenduni M, Strazzabosco M. Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation. Hepatology Communications 2023, 7: e0094. PMID: 36972396, PMCID: PMC10503667, DOI: 10.1097/hc9.0000000000000094.
Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytesRodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes. Hepatology Communications 2022, 6: 2748-2764. PMID: 35852334, PMCID: PMC9512452, DOI: 10.1002/hep4.2042.
584 Prominent role of gut dysbiosis in pathogenesis of cystic fibrosis–related cholangiopathyFiorotto R, Bertolini A, Nguyen M, Palm N, Strazzabosco M. 584 Prominent role of gut dysbiosis in pathogenesis of cystic fibrosis–related cholangiopathy. Journal Of Cystic Fibrosis 2022, 21: s324-s325. DOI: 10.1016/s1569-1993(22)01274-7.
Dysregulation of the Scribble/YAP/β‐catenin axis sustains the fibroinflammatory response in a PKHD1−/− mouse model of congenital hepatic fibrosisFabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. Dysregulation of the Scribble/YAP/β‐catenin axis sustains the fibroinflammatory response in a PKHD1−/− mouse model of congenital hepatic fibrosis. The FASEB Journal 2022, 36: e22364. PMID: 35593740, PMCID: PMC9150862, DOI: 10.1096/fj.202101924r.
Bile acids and their receptors: modulators and therapeutic targets in liver inflammationBertolini A, Fiorotto R, Strazzabosco M. Bile acids and their receptors: modulators and therapeutic targets in liver inflammation. Seminars In Immunopathology 2022, 44: 547-564. PMID: 35415765, PMCID: PMC9256560, DOI: 10.1007/s00281-022-00935-7.
Novel approaches to liver disease diagnosis and modelingOliveira AG, Fiorotto R. Novel approaches to liver disease diagnosis and modeling. Translational Gastroenterology And Hepatology 2021, 6: 19-19. PMID: 33824923, PMCID: PMC7829068, DOI: 10.21037/tgh-20-109.
New insights on the role of vascular endothelial growth factor in biliary pathophysiologyMariotti V, Fiorotto R, Cadamuro M, Fabris L, Strazzabosco M. New insights on the role of vascular endothelial growth factor in biliary pathophysiology. JHEP Reports 2021, 3: 100251. PMID: 34151244, PMCID: PMC8189933, DOI: 10.1016/j.jhepr.2021.100251.
IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expressionStein S, Henze L, Poch T, Carambia A, Krech T, Preti M, Schuran FA, Reich M, Keitel V, Fiorotto R, Strazzabosco M, Fischer L, Li J, Müller LM, Wagner J, Gagliani N, Herkel J, Schwinge D, Schramm C. IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression. Journal Of Hepatology 2020, 74: 919-930. PMID: 33197512, PMCID: PMC8778963, DOI: 10.1016/j.jhep.2020.10.035.
Abnormal Liver Function Tests in Patients With COVID‐19: Relevance and Potential PathogenesisBertolini A, van de Peppel I, Bodewes FAJA, Moshage H, Fantin A, Farinati F, Fiorotto R, Jonker JW, Strazzabosco M, Verkade HJ, Peserico G. Abnormal Liver Function Tests in Patients With COVID‐19: Relevance and Potential Pathogenesis. Hepatology 2020, 72: 1864-1872. PMID: 32702162, PMCID: PMC7404414, DOI: 10.1002/hep.31480.
PC.01.6 MODELING OF PRIMARY SCLEROSING CHOLANGITIS USING BILIARY SPHEROIDS DERIVED FROM BILE FLUID AND NEEDLE-LIVER BIOPSY SAMPLEMariotti V, Fantin A, Cadamuro M, Cagnin S, Fiorotto R, Floreani A, Guido M, Pontecorvi V, De Carlis L, Mutignani M, Cillo U, Strazzabosco M, Fabris L. PC.01.6 MODELING OF PRIMARY SCLEROSING CHOLANGITIS USING BILIARY SPHEROIDS DERIVED FROM BILE FLUID AND NEEDLE-LIVER BIOPSY SAMPLE. Digestive And Liver Disease 2020, 52: s3. DOI: 10.1016/s1590-8658(20)30510-7.
Recent Advances in Practical Methods for Liver Cell Biology: A Short OverviewTorres S, Abdullah Z, Brol MJ, Hellerbrand C, Fernandez M, Fiorotto R, Klein S, Königshofer P, Liedtke C, Lotersztajn S, Nevzorova YA, Schierwagen R, Reiberger T, Uschner FE, Tacke F, Weiskirchen R, Trebicka J. Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview. International Journal Of Molecular Sciences 2020, 21: 2027. PMID: 32188134, PMCID: PMC7139397, DOI: 10.3390/ijms21062027.
Cholangiocyte Biology and PathobiologyCadamuro M, Fiorotto R, Strazzabosco M. Cholangiocyte Biology and Pathobiology. 2020, 391-407. DOI: 10.1002/9781119436812.ch32.
Cholangiocyte biology and pathobiologyCadamuro M, Fiorotto R, Strazzabosco M. 2020. The liver: Biology and Pathobiology, 6th Edition. Arias IM, Alter HJ, Boyer JL, Cohen DE, Shafritz DA, Thorgeirsson SS, Wolkoff AW Eds. Whiley-Blackwell. ISBN: 978-1-119-43682-9
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseasesFabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases. Nature Reviews Gastroenterology & Hepatology 2019, 16: 497-511. PMID: 31165788, PMCID: PMC6661007, DOI: 10.1038/s41575-019-0156-4.
Pathophysiology of Cystic Fibrosis Liver Disease: A Channelopathy Leading to Alterations in Innate Immunity and in MicrobiotaFiorotto R, Strazzabosco M. Pathophysiology of Cystic Fibrosis Liver Disease: A Channelopathy Leading to Alterations in Innate Immunity and in Microbiota. Cellular And Molecular Gastroenterology And Hepatology 2019, 8: 197-207. PMID: 31075352, PMCID: PMC6664222, DOI: 10.1016/j.jcmgh.2019.04.013.
THU-493-Reciprocal changes in ARID1A and EZH2 are associated with cholangiocarcinoma development in a mouse model of caroli disease with high Yap expressionKaffe E, Spirli C, Fiorotto R, Mariotti V, Cadamuro M, Fabris L, Strazzabosco M. THU-493-Reciprocal changes in ARID1A and EZH2 are associated with cholangiocarcinoma development in a mouse model of caroli disease with high Yap expression. Journal Of Hepatology 2019, 70: e377-e378. DOI: 10.1016/s0618-8278(19)30740-6.
Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinomaCadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma. Journal Of Hepatology 2018, 70: 700-709. PMID: 30553841, PMCID: PMC10878126, DOI: 10.1016/j.jhep.2018.12.004.
Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseasesFiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2018, 1865: 920-928. PMID: 30264693, PMCID: PMC6658095, DOI: 10.1016/j.bbadis.2018.08.038.
Animal models of cholestasis: An update on inflammatory cholangiopathiesMariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Animal models of cholestasis: An update on inflammatory cholangiopathies. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2018, 1865: 954-964. PMID: 30398152, DOI: 10.1016/j.bbadis.2018.07.025.
Animal models for cystic fibrosis liver disease (CFLD)Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Animal models for cystic fibrosis liver disease (CFLD). Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2018, 1865: 965-969. PMID: 30071276, PMCID: PMC6474816, DOI: 10.1016/j.bbadis.2018.07.026.
Animal models of cholangiocarcinoma: What they teach us about the human diseaseCadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Animal models of cholangiocarcinoma: What they teach us about the human disease. Clinics And Research In Hepatology And Gastroenterology 2018, 42: 403-415. PMID: 29753731, DOI: 10.1016/j.clinre.2018.04.008.
β‐Catenin and interleukin‐1β–dependent chemokine (C‐X‐C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosisKaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C. β‐Catenin and interleukin‐1β–dependent chemokine (C‐X‐C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis. Hepatology 2018, 67: 1903-1919. PMID: 29140564, PMCID: PMC5906178, DOI: 10.1002/hep.29652.
SAT-151 Inhibition of YAP activation induces cell senescence and autophagy while blocking cell proliferation in cholangiocarcinoma (CCA)Cadamuro M, Casati G, Stecca T, Brivio S, Milani C, Mariotti V, Kaffe E, Spirli C, Amenduni M, Fiorotto R, Cillo U, Maria G, Fabris L, Strazzabosco M. SAT-151 Inhibition of YAP activation induces cell senescence and autophagy while blocking cell proliferation in cholangiocarcinoma (CCA). Journal Of Hepatology 2018, 68: s673. DOI: 10.1016/s0168-8278(18)31604-0.
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacyFiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy. Hepatology 2018, 67: 972-988. PMID: 28836688, PMCID: PMC5783790, DOI: 10.1002/hep.29400.
Notch signaling and progenitor/ductular reaction in steatohepatitisMorell CM, Fiorotto R, Meroni M, Raizner A, Torsello B, Cadamuro M, Spagnuolo G, Kaffe E, Sutti S, Albano E, Strazzabosco M. Notch signaling and progenitor/ductular reaction in steatohepatitis. PLOS ONE 2017, 12: e0187384. PMID: 29140985, PMCID: PMC5687773, DOI: 10.1371/journal.pone.0187384.
The deleterious interplay between tumor epithelia and stroma in cholangiocarcinomaCadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2017, 1864: 1435-1443. PMID: 28757170, PMCID: PMC6386155, DOI: 10.1016/j.bbadis.2017.07.028.
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epitheliumStrazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L. Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2017, 1864: 1374-1379. PMID: 28754453, PMCID: PMC5785585, DOI: 10.1016/j.bbadis.2017.07.023.
Emerging concepts in biliary repair and fibrosisFabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Emerging concepts in biliary repair and fibrosis. AJP Gastrointestinal And Liver Physiology 2017, 313: g102-g116. PMID: 28526690, PMCID: PMC5582882, DOI: 10.1152/ajpgi.00452.2016.
PS-058 Inhibition of IL-1b/STAT3/β-catenin-dependent stimulation of the CXCL10/CXCR3 axis prevents macrophage recruitment and progression of the disease in Pkhd1del4/del4 mice, a model of congenital hepatic fibrosisKaffe E, Pellegrino F, Mariotti V, Fabris L, Cadamuro M, Amenduni M, Fiorotto R, Strazzabosco M, Spirli C. PS-058 Inhibition of IL-1b/STAT3/β-catenin-dependent stimulation of the CXCL10/CXCR3 axis prevents macrophage recruitment and progression of the disease in Pkhd1del4/del4 mice, a model of congenital hepatic fibrosis. Journal Of Hepatology 2017, 66: s36-s37. DOI: 10.1016/s0168-8278(17)30334-3.
THU-420 Identification of Src tyrosine kinase as a therapeutic target in cystic fibrosis liver disease using patient specific induced pluripotent stem cells -derived cholangiocytesFiorotto R, Amenduni M, Cadamuro M, Spirli C, Strazzabosco M. THU-420 Identification of Src tyrosine kinase as a therapeutic target in cystic fibrosis liver disease using patient specific induced pluripotent stem cells -derived cholangiocytes. Journal Of Hepatology 2017, 66: s182. DOI: 10.1016/s0168-8278(17)30650-5.
The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activityFiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M. The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology 2016, 64: 2118-2134. PMID: 27629435, PMCID: PMC5115965, DOI: 10.1002/hep.28817.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver diseaseSpirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease. Journal Of Hepatology 2016, 66: 571-580. PMID: 27826057, PMCID: PMC5316496, DOI: 10.1016/j.jhep.2016.10.032.
Cystic Fibrosis–Related Liver Diseases: New Paradigm for Treatment Based on PathophysiologyFiorotto R, Strazzabosco M. Cystic Fibrosis–Related Liver Diseases: New Paradigm for Treatment Based on Pathophysiology. Clinical Liver Disease 2016, 8: 113-116. PMID: 31041076, PMCID: PMC6490209, DOI: 10.1002/cld.583.
749 Inhibition of the CA2+-Inhibited Adenylyl Cyclase 5 Reduces Cyst Growth in Mice With Polycystic Liver Disease (ADPKD) Caused By Defective Polycystin-2Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. 749 Inhibition of the CA2+-Inhibited Adenylyl Cyclase 5 Reduces Cyst Growth in Mice With Polycystic Liver Disease (ADPKD) Caused By Defective Polycystin-2. Gastroenterology 2016, 150: s1046. DOI: 10.1016/s0016-5085(16)33534-x.
Macrophage recruitment by fibrocystin‐defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosisLocatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell C, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Macrophage recruitment by fibrocystin‐defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology 2016, 63: 965-982. PMID: 26645994, PMCID: PMC4764460, DOI: 10.1002/hep.28382.
THU-433 Inhibition of the CA2+-Inhibited Adenylyl Cyclase 5 Reduces CYST Growth in Mice with Polycystic Liver Disease (ADPKD) Caused by Defective Polycystin-2Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. THU-433 Inhibition of the CA2+-Inhibited Adenylyl Cyclase 5 Reduces CYST Growth in Mice with Polycystic Liver Disease (ADPKD) Caused by Defective Polycystin-2. Journal Of Hepatology 2016, 64: s297. DOI: 10.1016/s0168-8278(16)00378-0.
PS095 Expansion and Polarization of Cholangiocytes from Human Induced Pluripotent Stem Cells (Ipsc)Amenduni M, Fiorotto R, Mariotti V, Spirli C, Strazzabosco M. PS095 Expansion and Polarization of Cholangiocytes from Human Induced Pluripotent Stem Cells (Ipsc). Journal Of Hepatology 2016, 64: s181. DOI: 10.1016/s0168-8278(16)00114-8.
Stimulation of nuclear receptor peroxisome proliferator–activated receptor‐γ limits NF‐κB‐dependent inflammation in mouse cystic fibrosis biliary epitheliumScirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M. Stimulation of nuclear receptor peroxisome proliferator–activated receptor‐γ limits NF‐κB‐dependent inflammation in mouse cystic fibrosis biliary epithelium. Hepatology 2015, 62: 1551-1562. PMID: 26199136, PMCID: PMC4618241, DOI: 10.1002/hep.28000.
Ezrin finds its groove in cholangiocytesFouassier L, Fiorotto R. Ezrin finds its groove in cholangiocytes. Hepatology 2015, 61: 1467-1470. PMID: 25545157, PMCID: PMC4406785, DOI: 10.1002/hep.27675.
P1141 : Post-translational regulation of polycystin 2 (PC2) expression as a novel mechanism of cholangiocyte reaction to biliary damage and repairSpirli C, Villani A, Morell C, Fabris L, Fiorotto R, Strazzabosco M. P1141 : Post-translational regulation of polycystin 2 (PC2) expression as a novel mechanism of cholangiocyte reaction to biliary damage and repair. Journal Of Hepatology 2015, 62: s779-s780. DOI: 10.1016/s0168-8278(15)31338-6.
Post-translational regulation of Polycystin 2 (PC2)expression as a novel mechanism of cholangiocyte reaction to biliary damage and repairSpirli C, Villani A, Morell C, Fabris L, Fiorotto R, Strazzabosco M. Post-translational regulation of Polycystin 2 (PC2)expression as a novel mechanism of cholangiocyte reaction to biliary damage and repair. Digestive And Liver Disease 2015, 47: e26. DOI: 10.1016/j.dld.2015.01.059.
Stimulation of Nuclear Receptor PPAR-γ Limits NF-kB-dependent Inflammation in Cystic Fibrosis Biliary EpitheliumScirpo R, Fiorotto R, Villani A, Fabris L, Strazzabosco M. Stimulation of Nuclear Receptor PPAR-γ Limits NF-kB-dependent Inflammation in Cystic Fibrosis Biliary Epithelium. Digestive And Liver Disease 2015, 47: e43-e44. DOI: 10.1016/j.dld.2015.01.096.
The Cystic Fibrosis Conductance Regular (CFTR) controls c-Src tyrosine kinase signaling and regulates innate immunity and epithelial polarity in cholangiocytesFiorotto R, Villani A, Scirpo R, Spirli C, Strazzabosco M. The Cystic Fibrosis Conductance Regular (CFTR) controls c-Src tyrosine kinase signaling and regulates innate immunity and epithelial polarity in cholangiocytes. Digestive And Liver Disease 2015, 47: e2. DOI: 10.1016/j.dld.2015.01.010.
P1253 ACTIVATION OF PPAR-γ SIGNALING AS A NOVEL TARGET TO LIMIT NF-κB-DEPENDENT INFLAMMATION IN CYSTIC FIBROSIS BILIARY EPITHELIUMScirpo R, Fiorotto R, Fabris L, Strazzabosco M. P1253 ACTIVATION OF PPAR-γ SIGNALING AS A NOVEL TARGET TO LIMIT NF-κB-DEPENDENT INFLAMMATION IN CYSTIC FIBROSIS BILIARY EPITHELIUM. Journal Of Hepatology 2014, 60: s507. DOI: 10.1016/s0168-8278(14)61413-6.
P1249 CFTR CONTROLS A MEMBRANE MULTI-PROTEIN COMPLEX THAT REGULATES CHOLANGIOCYTE C-SRC TYROSINE KINASE ACTIVITY AND TLR4 SIGNALING: IMPLICATIONS FOR CYSTIC FIBROSIS LIVER DISEASE (CFLD)Fiorotto R, Villani A, Scirpo R, Spirli C, Strazzabosco M. P1249 CFTR CONTROLS A MEMBRANE MULTI-PROTEIN COMPLEX THAT REGULATES CHOLANGIOCYTE C-SRC TYROSINE KINASE ACTIVITY AND TLR4 SIGNALING: IMPLICATIONS FOR CYSTIC FIBROSIS LIVER DISEASE (CFLD). Journal Of Hepatology 2014, 60: s506. DOI: 10.1016/s0168-8278(14)61409-4.
Protein kinase a‐dependent pSer675‐β‐catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosisSpirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Protein kinase a‐dependent pSer675‐β‐catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology 2013, 58: 1713-1723. PMID: 23744610, PMCID: PMC3800498, DOI: 10.1002/hep.26554.
Platelet‐derived growth factor‐D and Rho GTPases regulate recruitment of cancer‐associated fibroblasts in cholangiocarcinomaCadamuro M, Nardo G, Indraccolo S, Dall'Olmo L, Sambado L, Moserle L, Franceschet I, Colledan M, Massani M, Stecca T, Bassi N, Morton S, Spirli C, Fiorotto R, Fabris L, Strazzabosco M. Platelet‐derived growth factor‐D and Rho GTPases regulate recruitment of cancer‐associated fibroblasts in cholangiocarcinoma. Hepatology 2013, 58: 1042-1053. PMID: 23505219, PMCID: PMC3732815, DOI: 10.1002/hep.26384.
Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesisMorell CM, Fiorotto R, Fabris L, Strazzabosco M. Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis. Clinics And Research In Hepatology And Gastroenterology 2013, 37: 447-454. PMID: 23806629, DOI: 10.1016/j.clinre.2013.05.008.
137 CXCL1 AND CXCL10 SECRETION BY FIBROCYSTIN-DEFECTIVE CHOLANGIOCYTES RECRUITS PERIBILIARY FIBROCYTES IN CONGENITAL HEPATIC FIBROSISFabris L, Locatelli L, Viganò D, De Matteis M, Fiorotto R, Cadamuro M, Spirli C, Strazzabosco M. 137 CXCL1 AND CXCL10 SECRETION BY FIBROCYSTIN-DEFECTIVE CHOLANGIOCYTES RECRUITS PERIBILIARY FIBROCYTES IN CONGENITAL HEPATIC FIBROSIS. Journal Of Hepatology 2013, 58: s60. DOI: 10.1016/s0168-8278(13)60139-7.
Notch signaling regulates tubular morphogenesis during repair from biliary damage in miceFiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. Journal Of Hepatology 2013, 59: 124-130. PMID: 23500150, PMCID: PMC3777645, DOI: 10.1016/j.jhep.2013.02.025.
OC-01 CXCL1 and CXCL10 secretion by Fibrocistin-defective cholangiocytes recruits peribiliary fibrocytes in congenital hepatic fibrosisLocatelli L, Viganò D, De Matteis M, Fiorotto R, Cadamuro M, Spirlì C, Fabris L, Strazzabosco M. OC-01 CXCL1 and CXCL10 secretion by Fibrocistin-defective cholangiocytes recruits peribiliary fibrocytes in congenital hepatic fibrosis. Digestive And Liver Disease 2013, 45: s1. DOI: 10.1016/s1590-8658(13)00053-4.
O5 GUT–LIVER AXIS AND ALTERED TLR INNATE IMMUNITY IN THE PATHOGENESIS OF CYSTIC FIBROSIS LIVER DISEASEFiorotto R, Scirpo R, Spirli C, Strazzabosco M. O5 GUT–LIVER AXIS AND ALTERED TLR INNATE IMMUNITY IN THE PATHOGENESIS OF CYSTIC FIBROSIS LIVER DISEASE. Digestive And Liver Disease 2012, 44: s236-s237. DOI: 10.1016/s1590-8658(12)60751-8.
Cyclic AMP/PKA‐dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin‐2 defective mice treated with sorafenibSpirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M. Cyclic AMP/PKA‐dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin‐2 defective mice treated with sorafenib. Hepatology 2012, 56: 2363-2374. PMID: 22653837, PMCID: PMC3460040, DOI: 10.1002/hep.25872.
Altered store operated calcium entry increases cyclic 3′,5′‐adenosine monophosphate production and extracellular signal‐regulated kinases 1 and 2 phosphorylation in polycystin‐2‐defective cholangiocytesSpirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M. Altered store operated calcium entry increases cyclic 3′,5′‐adenosine monophosphate production and extracellular signal‐regulated kinases 1 and 2 phosphorylation in polycystin‐2‐defective cholangiocytes. Hepatology 2012, 55: 856-868. PMID: 21987453, PMCID: PMC3272110, DOI: 10.1002/hep.24723.
Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB—Mediated Inflammatory Response in MiceFiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB—Mediated Inflammatory Response in Mice. Gastroenterology 2011, 141: 1498-1508.e5. PMID: 21712022, PMCID: PMC3186841, DOI: 10.1053/j.gastro.2011.06.052.
701 INAPPROPRIATE STORE-OPERATED CYCLIC-AMP PRODUCTION LINKS ALTERED ENDOPLASMIC RETICULUM (ER) CA2+ HOMEOSTASIS TO ERK/VEGF SIGNALING IN TRPP2-DEFECTIVE CHOLANGIOCYTES IN A MOUSE MODEL OF POLYCYSTIC LIVER DISEASESpirli C, Locatelli L, Fiorotto R, Fabris L, Strazzabosco M. 701 INAPPROPRIATE STORE-OPERATED CYCLIC-AMP PRODUCTION LINKS ALTERED ENDOPLASMIC RETICULUM (ER) CA2+ HOMEOSTASIS TO ERK/VEGF SIGNALING IN TRPP2-DEFECTIVE CHOLANGIOCYTES IN A MOUSE MODEL OF POLYCYSTIC LIVER DISEASE. Journal Of Hepatology 2011, 54: s281. DOI: 10.1016/s0168-8278(11)60703-4.
50 PKA-DEPENDENT P-SER-675β-CATENIN PHOSPHORYLATION INCREASES CHOLANGIOCYTE MOTILITY IN PKHDDEL4/DEL4 MICE, A MODEL OF FIBROPOLYCYSTIC LIVER DISEASES CAUSED BY DEFECTIVE FIBROCYSTIN FUNCTIONSpirli C, Locatelli L, Fiorotto R, Morell C, Cadamuro M, Fabris L, Strazzabosco M. 50 PKA-DEPENDENT P-SER-675β-CATENIN PHOSPHORYLATION INCREASES CHOLANGIOCYTE MOTILITY IN PKHDDEL4/DEL4 MICE, A MODEL OF FIBROPOLYCYSTIC LIVER DISEASES CAUSED BY DEFECTIVE FIBROCYSTIN FUNCTION. Journal Of Hepatology 2011, 54: s22-s23. DOI: 10.1016/s0168-8278(11)60052-4.
OC.10.4: PKA-DEPENDENT P-SER-675β-CATENIN PHOSPHORYLATION INCREASES CHOLANGIOCYTE MOTILITY IN A MOUSE MODEL OF FIBROPOLYCYSTIC LIVER DISEASESSpirli C, Locatelli L, Fiorotto R, Morell C, Cadamuro M, Fabris L, Strazzabosco M. OC.10.4: PKA-DEPENDENT P-SER-675β-CATENIN PHOSPHORYLATION INCREASES CHOLANGIOCYTE MOTILITY IN A MOUSE MODEL OF FIBROPOLYCYSTIC LIVER DISEASES. Digestive And Liver Disease 2011, 43: s141. DOI: 10.1016/s1590-8658(11)60210-7.
P.1.63: ACTIVATION OF STORE-OPERATED CAMP SIGNALING IS RESPONSIBLE FOR ERK 1/2 PHOSPHORYLATION IN POLYCYSTIN-2/TRPP2 DEFECTIVE CHOLANGIOCYTESSpirli C, Locatelli L, Fiorotto R, Fabris L, Strazzabosco M. P.1.63: ACTIVATION OF STORE-OPERATED CAMP SIGNALING IS RESPONSIBLE FOR ERK 1/2 PHOSPHORYLATION IN POLYCYSTIN-2/TRPP2 DEFECTIVE CHOLANGIOCYTES. Digestive And Liver Disease 2011, 43: s169. DOI: 10.1016/s1590-8658(11)60291-0.
OC8 Defective progenitor cells activation and biliary tubule formation in liver conditional RBP-Jk-knock out mice exposed to cholestatic injuries reveals a key role for Notch signaling in liver repairFiorotto R, Spirli C, Scirpo R, Gridley T, Huppert S, Torsello B, Ferrero C, Strazzabosco M. OC8 Defective progenitor cells activation and biliary tubule formation in liver conditional RBP-Jk-knock out mice exposed to cholestatic injuries reveals a key role for Notch signaling in liver repair. Digestive And Liver Disease 2010, 42: s313-s314. DOI: 10.1016/s1590-8658(10)60530-0.
45 LACK OF CFTR AFFECTS THE INNATE IMMUNITY OF THE BILIARY EPITHELIUM AND DETERMINES A TLR4/NF-κB-MEDIATED INFLAMMATORY RESPONSEFiorotto R, Scirpo R, Spirli C, Trauner M, Strazzabosco M. 45 LACK OF CFTR AFFECTS THE INNATE IMMUNITY OF THE BILIARY EPITHELIUM AND DETERMINES A TLR4/NF-κB-MEDIATED INFLAMMATORY RESPONSE. Journal Of Hepatology 2010, 52: s20. DOI: 10.1016/s0168-8278(10)60047-5.
99 PROGENITOR CELL ACTIVATION AND LIVER REPAIR IS ALTERED IN NOTCH2- AND RBP-Jκ-DEFECTIVE MICE EXPOSED TO CHOLESTATIC INJURIESFiorotto R, Spirli C, Scirpo R, Gridley T, Huppert S, Torcello B, Ferrero C, Strazzabosco M. 99 PROGENITOR CELL ACTIVATION AND LIVER REPAIR IS ALTERED IN NOTCH2- AND RBP-Jκ-DEFECTIVE MICE EXPOSED TO CHOLESTATIC INJURIES. Journal Of Hepatology 2010, 52: s45. DOI: 10.1016/s0168-8278(10)60101-8.
Cholangiocyte Biology as Relevant to Cystic Liver DiseasesLecchi S, Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Cholangiocyte Biology as Relevant to Cystic Liver Diseases. 2010, 23-43. DOI: 10.1007/978-1-60327-524-8_2.
T.N.1 LACK OF CFTR AFFECTS THE INNATE IMMUNITY OF THE BILIARY EPITHELIUM AND DETERMINES A TLR4/NF-κB-MEDIATED INFLAMMATORY RESPONSEFiorotto R, Scirpo R, Spirli C, Trauner M, Strazzabosco M. T.N.1 LACK OF CFTR AFFECTS THE INNATE IMMUNITY OF THE BILIARY EPITHELIUM AND DETERMINES A TLR4/NF-κB-MEDIATED INFLAMMATORY RESPONSE. Digestive And Liver Disease 2010, 42: s15. DOI: 10.1016/s1590-8658(10)60406-9.
F.N.3 PROGENITOR CELL ACTIVATION AND LIVER REPAIR IS ALTERED IN NOTCH2- AND RBP-Jκ-DEFECTIVE MICE EXPOSED TO CHOLESTATIC INJURIESFiorotto R, Spirli C, Scirpo R, Gridley T, Huppert S, Torsello B, Ferrero C, Strazzabosco M. F.N.3 PROGENITOR CELL ACTIVATION AND LIVER REPAIR IS ALTERED IN NOTCH2- AND RBP-Jκ-DEFECTIVE MICE EXPOSED TO CHOLESTATIC INJURIES. Digestive And Liver Disease 2010, 42: s33-s34. DOI: 10.1016/s1590-8658(10)60457-4.
Cholangiocyte Biology as relevant to Cystic Liver DiseasesLecchi S, Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. 2010. In Fibrocystic Diseases of the Liver. KF. Murray and AM. Larson eds. Humana Press, Springer Science Business Media, LLC, Totowa, NJ, USA. ISBN 978-1-60327-524-8.
Mammalian target of rapamycin regulates vascular endothelial growth factor–dependent liver cyst growth in polycystin‐2–defective miceSpirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Mammalian target of rapamycin regulates vascular endothelial growth factor–dependent liver cyst growth in polycystin‐2–defective mice. Hepatology 2009, 51: 1778-1788. PMID: 20131403, PMCID: PMC2930014, DOI: 10.1002/hep.23511.
ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective MiceSpirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective Mice. Gastroenterology 2009, 138: 360-371.e7. PMID: 19766642, PMCID: PMC3000794, DOI: 10.1053/j.gastro.2009.09.005.
72 RAPAMYCIN INHIBITS CYST GROWTH, IGF-1-MEDIATED VEGF SECRETION AND CELL PROLIFERATION IN POLYCYSTIN-2 DEFECTIVE MICE, A MODEL FOR POLYCYSTIC LIVER DISEASE (PLD) ASSOCIATED TO ADULT-DOMINANT-POLYCYSTIC-KIDNEY-DISEASE (ADPKD)Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lechhi S, Tiang X, Somlo S, Strazzabosco M. 72 RAPAMYCIN INHIBITS CYST GROWTH, IGF-1-MEDIATED VEGF SECRETION AND CELL PROLIFERATION IN POLYCYSTIN-2 DEFECTIVE MICE, A MODEL FOR POLYCYSTIC LIVER DISEASE (PLD) ASSOCIATED TO ADULT-DOMINANT-POLYCYSTIC-KIDNEY-DISEASE (ADPKD). Journal Of Hepatology 2009, 50: s30. DOI: 10.1016/s0168-8278(09)60074-x.
The Vibrio cholerae Cytolysin Promotes Chloride Secretion from Intact Human Intestinal MucosaDebellis L, Diana A, Arcidiacono D, Fiorotto R, Portincasa P, Altomare DF, Spirlì C, de Bernard M. The Vibrio cholerae Cytolysin Promotes Chloride Secretion from Intact Human Intestinal Mucosa. PLOS ONE 2009, 4: e5074. PMID: 19333391, PMCID: PMC2659442, DOI: 10.1371/journal.pone.0005074.
Diferentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulationStrazzabosco M, Fiorotto R, Melero S, Glaser S, Francis H, Spirli C, Alpini G. Diferentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology 2009, 50: 244-252. PMID: 19444869, PMCID: PMC2738985, DOI: 10.1002/hep.22926.
Nuclear expression of S100A4, an early marker of epithelial–mesenchymal transition (EMT), predicts a more aggressive behaviour in cholangiocarcinomaCadamuro M, Fabris L, Moserle L, Vezzoli S, Spirli C, Fiorotto R, Locatelli L, Gazzola A, Furlanetto A, Sonzogni A, Colledan M, Fagiuoli S, Indraccolo S, Okolicsanyi L, Strazzabosco M. Nuclear expression of S100A4, an early marker of epithelial–mesenchymal transition (EMT), predicts a more aggressive behaviour in cholangiocarcinoma. Digestive And Liver Disease 2009, 41: a16-a17. DOI: 10.1016/j.dld.2008.12.036.
Rapamycin inhibits cyst growth, IGF-1-mediated VEGF secretion and cell proliferation in polycystin-2 defective miceSpirlì C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Rapamycin inhibits cyst growth, IGF-1-mediated VEGF secretion and cell proliferation in polycystin-2 defective mice. Digestive And Liver Disease 2009, 41: a2. DOI: 10.1016/j.dld.2008.12.009.
Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− miceHalilbasic E, Fiorotto R, Fickert P, Marschall H, Moustafa T, Spirli C, Fuchsbichler A, Gumhold J, Silbert D, Zatloukal K, Langner C, Maitra U, Denk H, Hofmann AF, Strazzabosco M, Trauner M. Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice. Hepatology 2009, 49: 1972-1981. PMID: 19475687, PMCID: PMC3569724, DOI: 10.1002/hep.22891.
Side-chain modification as critical determinant of the therapeutic properties of 24-norursodeoxycholic acid in Mdr2 (Abcb4) knockout miceHalilbasic E, Fickert P, Fiorotto R, Marschall H, Moustafa T, Fuchsbichler A, Gumhold J, Silbert D, Langner C, Maitra U, Denk H, Strazzabosco M, Trauner M. Side-chain modification as critical determinant of the therapeutic properties of 24-norursodeoxycholic acid in Mdr2 (Abcb4) knockout mice. 2009, 157-162. DOI: 10.1007/978-1-4020-9644-0_21.
Role of Angiogenesis and Angiogenic Factors for Cholangiocyte GrowthSpirli C, Fabris L, Fiorotto R, Cadamuro M, Okolicsanyi S, Strazzabosco M. 2009. In Pathophysiology of the Intrahepatic Biliary Epithelium. S. DeMorrow, M. Marzioni, G. Fava, S. Glaser and G. Alpini eds. Transworld Research Network. ISBN 978-8178953373.
ROLE OF CFTR IN BILE SECRETIONStrazzabosco M, Spirli C, Fiorotto R. ROLE OF CFTR IN BILE SECRETION. Journal Of Cystic Fibrosis 2008, 7: s4. DOI: 10.1016/s1569-1993(08)60482-8.
Evidence for epithelial–mesenchymal transition in the biliary epithelium of human cholangiocarcinomaFabris L, Cadamuro M, Spirlì C, Fiorotto R, Sonzogni A, Colledan M, Fagiuoli S, Okolicsanyi L, Strazzabosco M. Evidence for epithelial–mesenchymal transition in the biliary epithelium of human cholangiocarcinoma. Digestive And Liver Disease 2008, 40: a10-a11. DOI: 10.1016/j.dld.2007.12.041.
325 EVIDENCE FOR BILIARY EPITHELIAL TO MESENCHYMAL TRANSITION IN HUMAN CHOLANGIOCARCINOMAFabris L, Cadamuro M, Spirli C, Fiorotto R, Sonzogni A, Colledan M, Fagiuoli S, Okolicsanyi L, Strazzabosco M. 325 EVIDENCE FOR BILIARY EPITHELIAL TO MESENCHYMAL TRANSITION IN HUMAN CHOLANGIOCARCINOMA. Journal Of Hepatology 2008, 48: s128. DOI: 10.1016/s0168-8278(08)60327-x.
Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver developmentFabris L, Cadamuro M, Libbrecht L, Raynaud P, Spirlì C, Fiorotto R, Okolicsanyi L, Lemaigre F, Strazzabosco M, Roskams T. Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development. Hepatology 2007, 47: 719-728. PMID: 18157837, DOI: 10.1002/hep.22015.
Ursodeoxycholic Acid Stimulates Cholangiocyte Fluid Secretion in Mice via CFTR-Dependent ATP SecretionFiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M. Ursodeoxycholic Acid Stimulates Cholangiocyte Fluid Secretion in Mice via CFTR-Dependent ATP Secretion. Gastroenterology 2007, 133: 1603-1613. PMID: 17983806, DOI: 10.1053/j.gastro.2007.08.071.
Analysis of Liver Repair Mechanisms in Alagille Syndrome and Biliary Atresia Reveals a Role for Notch SignalingFabris L, Cadamuro M, Guido M, Spirli C, Fiorotto R, Colledan M, Torre G, Alberti D, Sonzogni A, Okolicsanyi L, Strazzabosco M. Analysis of Liver Repair Mechanisms in Alagille Syndrome and Biliary Atresia Reveals a Role for Notch Signaling. American Journal Of Pathology 2007, 171: 641-653. PMID: 17600123, PMCID: PMC1934520, DOI: 10.2353/ajpath.2007.070073.
[105] ARTERIAL AND PERIBILIARY VASCULOGENESIS DURING LIVER DEVELOPMENT IS MODULATED BY ANGIOGENIC GROWTH FACTORS EXPRESSED BY DUCTAL PLATE CELLS AND HEPATOBLASTSFabris L, Cadamuro M, Libbrecht L, Spirli C, Fiorotto R, Okolicsanyi L, Roskams T, Strazzabosco M. [105] ARTERIAL AND PERIBILIARY VASCULOGENESIS DURING LIVER DEVELOPMENT IS MODULATED BY ANGIOGENIC GROWTH FACTORS EXPRESSED BY DUCTAL PLATE CELLS AND HEPATOBLASTS. Journal Of Hepatology 2007, 46: s46-s47. DOI: 10.1016/s0168-8278(07)61703-6.
Arterial and peribiliary vasculogenesis during liver development is modulated by angiogenic growth factors expressed by ductal plate cells and hepatoblastsFabris L, Cadamuro M, Libbrecht L, Spirlì C, Fiorotto R, Okolicsanyi L, Roskams T, Strazzabosco M. Arterial and peribiliary vasculogenesis during liver development is modulated by angiogenic growth factors expressed by ductal plate cells and hepatoblasts. Digestive And Liver Disease 2007, 39: a2. DOI: 10.1016/j.dld.2006.12.023.
Synthesis and cytotoxicity properties of amiodarone analoguesBigler L, Spirli C, Fiorotto R, Pettenazzo A, Duner E, Baritussio A, Follath F, Ha HR. Synthesis and cytotoxicity properties of amiodarone analogues. European Journal Of Medicinal Chemistry 2007, 42: 861-867. PMID: 17316909, DOI: 10.1016/j.ejmech.2006.12.031.
Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseasesFabris L, Cadamuro M, Fiorotto R, Roskams T, Spirlì C, Melero S, Sonzogni A, Joplin RE, Okolicsanyi L, Strazzabosco M. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. Hepatology 2006, 43: 1001-1012. PMID: 16628643, DOI: 10.1002/hep.21143.
Altered jagged-1/notch signalling influences liver repair mechanisms in alagille syndromeFabris L, Cadamuro M, Sonzogni A, Spirli C, Fiorotto R, Torre G, Colledan M, Okolicsanyi L, Strazzabosco M. Altered jagged-1/notch signalling influences liver repair mechanisms in alagille syndrome. Digestive And Liver Disease 2006, 38: s34-s35. DOI: 10.1016/s1590-8658(06)80088-5.
Glibenclamide Stimulates Fluid Secretion in Rodent Cholangiocytes Through a Cystic Fibrosis Transmembrane Conductance Regulator-Independent MechanismSpirlì C, Fiorotto R, Song L, Santos-Sacchi J, Okolicsanyi L, Masier S, Rocchi L, Vairetti MP, de Bernard M, Melero S, Pozzan T, Strazzabosco M. Glibenclamide Stimulates Fluid Secretion in Rodent Cholangiocytes Through a Cystic Fibrosis Transmembrane Conductance Regulator-Independent Mechanism. Gastroenterology 2005, 129: 220-233. PMID: 16012949, DOI: 10.1053/j.gastro.2005.03.048.
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytesSpirlì C, Fabris L, Duner E, Fiorotto R, Ballardini G, Roskams T, Larusso NF, Sonzogni A, Okolicsanyi L, Strazzabosco M. Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. Gastroenterology 2003, 124: 737-753. PMID: 12612912, DOI: 10.1053/gast.2003.50100.
1103 Expression and regulation of adenylyl cyclase isoforms (ACS) in rat cholangiocytes; effects of lipopolysaccaride (LPS) and α-napthylisothiocyanate (ANIT) treatmentMelero S, Strazzabosco M, Spirlí C, Fiorotto R, Glaser S, Francis H, Alpini G. 1103 Expression and regulation of adenylyl cyclase isoforms (ACS) in rat cholangiocytes; effects of lipopolysaccaride (LPS) and α-napthylisothiocyanate (ANIT) treatment. Hepatology 2003, 38: 687. DOI: 10.1016/s0270-9139(03)81141-2.
4 P Glibenclamide induces ductal secretion stimulating vesicular transport in cholangiocytesSpirli C, Fiorotto R, Duner E, Masier S, Cadamuro M, Okolicsanyi L, Strazzabosco M. 4 P Glibenclamide induces ductal secretion stimulating vesicular transport in cholangiocytes. Digestive And Liver Disease 2002, 34: a49. DOI: 10.1016/s1590-8658(02)90190-8.
Glibenclamide induces ductal secretion stimulating vesicular transport in cholangiocytesSpirli C, Fiorotto R, Duner E, Masier S, Cadamuro M, Strazzabosco M. Glibenclamide induces ductal secretion stimulating vesicular transport in cholangiocytes. Journal Of Hepatology 2002, 36: 142. DOI: 10.1016/s0168-8278(02)80511-6.
Reaction of Cholangiocytes to inflammatory injurySpirlì C, Duner E, Fiorotto R, Fabris L, Strazzabosco M. 2002. In “Cytokines in liver injury and repair” AM. Gressner ed. Kluwer Academic Publishers. ISBN 978-0792387756
Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct EpitheliumSpirlı̀ C, Nathanson M, Fiorotto R, Duner E, Denson L, Sanz J, Di Virgilio F, Okolicsanyi L, Casagrande F, Strazzabosco M. Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium. Gastroenterology 2001, 121: 156-169. PMID: 11438505, DOI: 10.1053/gast.2001.25516.
Electrolyte transport by bile duct cells.Strazzabosco M, Spirlì C, Fiorotto R, Duner E, Zsembery A, Graf J, Okolicsanyi L. 2001. In “Hepatobiliary transport: from bench to beside” R. Matern, JL.Boyer, D. Keppler, P. Meier-Abt eds. Kluwer Academic Publishers. ISBN 978-0792387718.

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Hepatitis; HIV/AIDS; Immune System; Infectious Diseases	Screening In Anticipation of Future Research

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