Petr Protiva, MD, MPH

• Anil Nagar
• Avlin Imaeda
• Fred Sanford Gorelick
• Gary Désir
• Jill Gaidos
• Tassos C. Kyriakides
• Yasuko Iwakiri

Colorectal Neoplasms; Molecular Epidemiology; Endpoint Determination; Nontherapeutic Human Experimentation; Therapeutic Human Experimentation

Biomarkers; Cancer; Clinical Trials; Genetics, Genomics, Epigenetics; Nutrition

• Endoscopic drainage of pancreatic fluid collections: Does hospital volume impact outcomes?Ketwaroo G, Protiva P. Endoscopic drainage of pancreatic fluid collections: Does hospital volume impact outcomes? Gastrointestinal Endoscopy 2023, 98: 607-608. PMID: 37734815, DOI: 10.1016/j.gie.2023.06.057.
• S290 Primary Squamous Cell Carcinoma of the Colon Is Extremely Rare and Shows Poor SurvivalProtiva L, Ketwaroo G, Protiva P. S290 Primary Squamous Cell Carcinoma of the Colon Is Extremely Rare and Shows Poor Survival. The American Journal Of Gastroenterology 2023, 118: s214-s215. DOI: 10.14309/01.ajg.0000950800.62837.6b.
• S1805 Small Bowel Adenocarcinomas Exhibit Worse Mortality Compared to Neuroendocrine Tumors With Modulation by Clinical, Demographic, and Socioeconomic FactorsChung S, Khan F, Ketwaroo G, Protiva P. S1805 Small Bowel Adenocarcinomas Exhibit Worse Mortality Compared to Neuroendocrine Tumors With Modulation by Clinical, Demographic, and Socioeconomic Factors. The American Journal Of Gastroenterology 2023, 118: s1339-s1341. DOI: 10.14309/01.ajg.0000956860.65692.57.
• S3865 A Protein Paradox: A Case of Spontaneous Portosystemic Shunt Encephalopathy and Protein-Losing EnteropathyMaxwell M, Mezzacappa C, Hussain N, Protiva P, Cornman-Homonoff J, DiDomenico P, Ketwaroo G, Taddei T. S3865 A Protein Paradox: A Case of Spontaneous Portosystemic Shunt Encephalopathy and Protein-Losing Enteropathy. The American Journal Of Gastroenterology 2023, 118: s2470-s2471. DOI: 10.14309/01.ajg.0000965100.38497.c8.
• S1000 Exploring the Influence of COVID-19 Treatment on Real-World Outcomes in IBD Patients: A Comprehensive AnalysisSahyoun L, McMillan C, Fetene J, Protiva P, Al-Bawardy B, Gaidos J, Proctor D. S1000 Exploring the Influence of COVID-19 Treatment on Real-World Outcomes in IBD Patients: A Comprehensive Analysis. The American Journal Of Gastroenterology 2023, 118: s757-s757. DOI: 10.14309/01.ajg.0000953640.32433.d2.
• S457 Associations of Intratumoral Alphapapillomavirus With Survival Outcomes and Tumorigenic Pathways in Esophageal Squamous Cell CarcinomaChen G, Zaman S, McMillan C, Patel A, Segarra D, Protiva P. S457 Associations of Intratumoral Alphapapillomavirus With Survival Outcomes and Tumorigenic Pathways in Esophageal Squamous Cell Carcinoma. The American Journal Of Gastroenterology 2023, 118: s332-s333. DOI: 10.14309/01.ajg.0000951468.46020.24.
• Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening TrialRobertson D, Dominitz J, Beed A, Boardman K, Del Curto B, Guarino P, Imperiale T, LaCasse A, Larson M, Gupta S, Lieberman D, Planeta B, Shaukat A, Sultan S, Menees S, Saini S, Schoenfeld P, Goebel S, von Rosenvinge E, Baffy G, Halasz I, Pedrosa M, Kahng L, Cassim R, Greer K, Kinnard M, Bhatt D, Dunbar K, Harford W, Mengshol J, Olson J, Patel S, Antaki F, Fisher D, Sullivan B, Lenza C, Prajapati D, Wong H, Beyth R, Lieb J, Manlolo J, Ona F, Cole R, Khalaf N, Kahi C, Kohli D, Rai T, Sharma P, Anastasiou J, Hagedorn C, Fernando R, Jackson C, Jamal M, Lee R, Merchant F, May F, Pisegna J, Omer E, Parajuli D, Said A, Nguyen T, Tombazzi C, Feldman P, Jacob L, Koppelman R, Lehenbauer K, Desai D, Madhoun M, Tierney W, Ho M, Hockman H, Lopez C, Carter Paulson E, Tobi M, Pinillos H, Young M, Ho N, Mascarenhas R, Promrat K, Mutha P, Pandak W, Shah T, Schubert M, Pancotto F, Gawron A, Underwood A, Ho S, Magno-Pagatzaurtundua P, Toro D, Beymer C, Kaz A, Elwing J, Gill J, Goldsmith S, Yao M, Protiva P, Pohl H, Kyriakides T, Kleiner E, Sullivan K, O'Leary J, Chiu W, Huang H, Russo J, Johnson G, Antonelli P, Burns A, Peduzzi P, Ciarleglio M, O'Connor T, Wallace R, Williams A, Tommessilli L, Taylor S, Pitts S, Mancini L, O'Brien P, O'Neil S, Perry M, McBride V, Carr W, Joncas C, O'Donnell E, Sather M, Warren S, Conner T, Honstein E, Sutton T, Putnam T, Branham K, Argyres D, Peterson D, Kennedy A, Carrick T, Apodaca C, Eden G, Martinez T, Tripp C, Nicholson M, Schwartz A, Felix M, Ward A, Marquez L, Lovato K, Cochran N, Tapia S, VanRaden M, Badgett C, Taylor Z, Pontzer J, Dorman B, Chavez M, Georg S, Templton T, Calais L, Haakensen C, Curtis B, Prehoda M, Colling C, Older D, Apodaca G, Sova J, Klee M, Wolfram-Aduan A, Ulatowski M, Hamilton B, Bopp (Formerly England) K, Ford G, Lace N, McDonnell W, Piehl G, Patel-Ejarque N, Berry M, Strubeck E, Chesnut L, Burridge L, Bean J, Kowal L, Voorhees (Formerly Rose) A, Ridley A, Croteau H, Bessett K, Fletcher C, Barbaresso M, Drummond A, Belanger K, McRobert E, Myers A, Trumble E, Rose P, Biswas A, Enache E, Shankin M, Strunk D, Simpson A, Harrison M, Prasad M, Robinson P, Flores A, Jananeh S, Tanukonda S, Ahmadi-Izadi G, Madihi S, Raufman J, Grady D, Britton A, Goldstein C, Thomas M, Lee V, Belizaire M, Costa C, Davis S, Decker M, Marrama A, Gilroy-Fanaras D, Gass J, Reece S, Tobin D, Carroll R, Ferreira M, Irvin D, Morken V, Covelli M, Medina T, Schiebel F, Shreves A, Shriver D, Frederick Y, Postle (formerly Matheny) C, Shaw J, Pastor D, Armstrong A, Kumaran V, Pinto A, Marshall V, McLarty S, Carlton J, Murphy K, McLemore K, Mortensen E, LePage J, Willis C, Berman K, Dunn T, Espinoza J, Schleski E, Shrader S, Gropp K, Kanaan Z, Miller L, Anees M, Judd S, Berchou V, Balogh D, Jones E, Covert K, Davis Y, Marbury C, Rambus M, Olgren E, Gellad Z, Sullivan B, Day T, Teehan S, Peters L, Hernandez-Chavez R, Murphy E, Cherry J, Graham E, Johnson J, Wooten W, Trujillo J, Harris M, Alizadeh M, Lo M, Sultan S, Brown L, Koster L, LeLaurin J, Irwin A, Kay N, Mckillip S, Lowe M, Yeralan S, Leehey D, McBurney C, Jain A, Park T, Broadwater L, El-Serag H, Shaib Y, Taylor E, Nair P, Broussard E, Gibson E, Hawkins R, Natividad T, Courtade D, Palmer M, Martinez S, Panagiotis K, Morrow C, Ballard C, Barker B, Garner M, McCalley S, Schwartzkopf A, Wright A, Titi M, Higbee A, Pratiksha S, Jones A, Shipe T, McKee J, Vennalaganti R, Terrey K, Maruf L, Brown D, Crouse E, Marchant-Miros K, Ussery B, Ducker L, Estell J, Porchia S, Kim M, Kim C, Chan B, Hayton A, Christiansen H, Peterson M, Ding G, Simpson V, Read S, Mamani G, Salazar J, Kato J, Bowie M, Carnevale R, Halim M, Sahagian A, Ibarra A, Travis Z, Garcia J, Gill A, Starzyk J, Sumarli S, Johnson V, Peresuh S, Quimby T, Cordova R, Herold L, Hawley A, Goo T, Kidao J, Lee R, Freidel C, Gutierrez E, Noorisharghi N, Ivie G, Jawish T, Partin S, Yoo G, Fabilane C, Noori N, Lang E, Senen S, Partin S, Fathi M, Chauvin R, Feiger J, Reataza M, Morgan T, Asghar A, Jacobs J, Kashefi M, May F, Ohning G, Padua D, Smutko V, Oh D, Kosoyan H, Dreskin B, Luu K, Alas A, Bharath P, Dixit V, Sanford** D, Vu J, Kadi S, Nwajuaku T, Smith J, Kincaid J, Mir M, Lanceta J, Rice J, Agarwal P, Augustine A, Prickel H, Vue J, Guerrero K, Levenson S, Aguilera-Fish A, Chestnut L, Jobse B, Lombardo C, Silver T, Ahmed N, Bockhold K, Koppelman R, Carneiro F, Garcia-Morales R, Spector D, Gomez J, Lehenbauer K, Reinink A, Anway R, Evans-Lindquist M, Eggers T, Green M, Pretti A, Meyeraan T, Condon D, Cavanagh M, DeFalco C, Cutting J, Joseph K, Dean S, Mitchell S, Phillips V, Krueger C, Zink D, Goldberg K, Patel N, Martinez Gonzalez M, Davis-Underwood H, O'Sullivan A, Suppes T, Bratcher K, Stern D, Wu R, Damisa J, Warsi R, Nguyen T, Pinillos H, Flowers E, Kuramoto A, Thurmond C, Orozco L, Farrell G, Jaynes R, Saenz P, Perez C, Collins J, Lin E, Onstad L, Pitts A, Osborn K, Kenworthy-Heinige T, Casey A, Gold D, Olivo C, Joos S, Subramanian S, Forro V, Cannady A, Usih J, Raitt M, Flynn M, Shittu Y, Jawaid M, Anderson R, Poole D, Butler C, Snead L, Christine H, Swanson G, Heumann D, Pandak W, Spataro J, Bajaj J, Solomon C, Smith Gilles H, Zafass A, Tilak S, Fuchs M, Davis M, Blackman L, Lemler J, Munsey R, Deebo J, McCarthy J, Noel M, Hurley R, Zurowski W, Sharpe A, Wilson K, Peets R, Lorenso B, Burrison S, Johnson D, Angelovic A, Erickson N, Hanson H, Bailey T, Genung K, Dulin H, Neuharth R, Clegg D, Velarde K, Dever J, Murphy M, Beck D, Wasil M, Vazquez J, O'Neil E, Ganji G, Ducom J, Lee M, Hovespians R, Margolis J, Simmons B, Sweeney (formerly St. Martin) J, Henry R, Martin-Ortiz J, Santiago-Rivera L, Gonzalez - Aviles G, Pedrosa C, Bird-Caceres J, Padilla B, Baez-Corujo F, Martinez- Ortiz Y, Vazquez E, Grigg-Gutierrez N, Laboy-Olivieri C, Urbina-Velez R, Andrews S, Rosa-Cruz S, Tirado-Montijo R, Otero-Aponte K, Martinez-Martino M, Freire A, Soto-Ramos A, Santana-Perez M, Araujo J, Vanderwarker C, Alexander J, Nevins E, LaGuire J, Guerrero L, Piehl G, Jenkins M, Chen T, Jang J, Tanus A, McKelvy P, Sayuk G, Chandiramani P, Vargo (Formerly Shoults) L, Vargo K, Lawrence S, Blythe K, Goldsmith S, Campbell R, Craddock M, Amodeo D, Reinhard R, Durant B, Wells B, Zoble A, Papademetriou M, Roche N, Adler P, Krishna A, Glaze D, Wijegunawardana D, Yeroushalmi S, Laine L, Mautner R, Bugaj J, Anderson J, Croteau H, Kingman L, Burridge L. Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial. JAMA Network Open 2023, 6: e2321730. PMID: 37432690, PMCID: PMC10336619, DOI: 10.1001/jamanetworkopen.2023.21730.
• Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival studyChen G, Chen K, Sahyoun L, Zaman S, Protiva P. Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study. BMJ Open Gastroenterology 2023, 10: e001045. PMID: 36822658, PMCID: PMC9950880, DOI: 10.1136/bmjgast-2022-001045.
• S220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell InfiltrationChen G, Zaman S, Segarra D, Patel A, Protiva P. S220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell Infiltration. The American Journal Of Gastroenterology 2022, 117: e158-e158. DOI: 10.14309/01.ajg.0000857520.28843.4b.
• S209 Appendiceal Adenocarcinomas Are Associated With Better Prognosis Than Cecal Adenocarcinomas: A Population-Based Comparative Survival StudyChen G, Chen K, Rotundo L, Zaman S, Protiva P. S209 Appendiceal Adenocarcinomas Are Associated With Better Prognosis Than Cecal Adenocarcinomas: A Population-Based Comparative Survival Study. The American Journal Of Gastroenterology 2022, 117: e151-e152. DOI: 10.14309/01.ajg.0000857476.13762.f0.
• S208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal AdenocarcinomaZaman S, Chen G, Segarra D, Patel A, Protiva P. S208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal Adenocarcinoma. The American Journal Of Gastroenterology 2022, 117: e150-e151. DOI: 10.14309/01.ajg.0000857472.84764.69.
• S213 Intratumoral Human Cytomegalovirus Abundance in Colon Adenocarcinoma Is Associated With Poor Survival Outcomes and Increased Intratumoral Regulatory T-cell Infiltrate in Elderly PatientsZaman S, Chen G, Patel A, Segarra D, Protiva P. S213 Intratumoral Human Cytomegalovirus Abundance in Colon Adenocarcinoma Is Associated With Poor Survival Outcomes and Increased Intratumoral Regulatory T-cell Infiltrate in Elderly Patients. The American Journal Of Gastroenterology 2022, 117: e153-e154. DOI: 10.14309/01.ajg.0000857492.57792.96.
• Su1106: SOCIOECONOMIC AND DEMOGRAPHIC CHARACTERISTICS ARE ASSOCIATED WITH SURVIVAL EXPERIENCE IN MALIGNANT APPENDICEAL TUMORSChen G, Rotundo L, Chen K, Protiva P. Su1106: SOCIOECONOMIC AND DEMOGRAPHIC CHARACTERISTICS ARE ASSOCIATED WITH SURVIVAL EXPERIENCE IN MALIGNANT APPENDICEAL TUMORS. Gastroenterology 2022, 162: s-505. DOI: 10.1016/s0016-5085(22)61195-8.
• S80 Clinical and Socioeconomic Determinants of Survival in Gallbladder and Biliary AdenocarcinomaRotundo L, Tsay C, Protiva P. S80 Clinical and Socioeconomic Determinants of Survival in Gallbladder and Biliary Adenocarcinoma. The American Journal Of Gastroenterology 2021, 116: s34-s34. DOI: 10.14309/01.ajg.0000772300.66447.a1.
• S1410 Gastric Adenocarcinoma Involving the Pylorus: A Comparative Survival Analysis of Distal and Proximal TumorsTsay C, Rotundo L, Protiva P. S1410 Gastric Adenocarcinoma Involving the Pylorus: A Comparative Survival Analysis of Distal and Proximal Tumors. The American Journal Of Gastroenterology 2021, 116: s647-s648. DOI: 10.14309/01.ajg.0000779172.37232.37.
• S2141 Acute on Chronic Mesenteric Ischemia With Peristaltic BlanchingTsay C, Protiva P. S2141 Acute on Chronic Mesenteric Ischemia With Peristaltic Blanching. The American Journal Of Gastroenterology 2020, 115: s1130-s1130. DOI: 10.14309/01.ajg.0000710612.40428.51.
• Sa1354 – Sex and Age Disparities in Pancreatic Cancer SurvivalChung S, Nagar A, Kolodecik T, Shugrue C, Desir G, Gorelick F, Protiva P. Sa1354 – Sex and Age Disparities in Pancreatic Cancer Survival. Gastroenterology 2019, 156: s-324. DOI: 10.1016/s0016-5085(19)37641-3.
• 871 – Transcriptional Signatures of Western-Style and Prudent Diets in Human ColonProtiva P, Khaliqdina S, Pendyala S, Holt P. 871 – Transcriptional Signatures of Western-Style and Prudent Diets in Human Colon. Gastroenterology 2019, 156: s-196. DOI: 10.1016/s0016-5085(19)37280-4.
• Vitamin D and Colorectal CancerDo A, Protiva P. Vitamin D and Colorectal Cancer. 2018, 103-114. DOI: 10.1007/978-3-319-73742-3_5.
• Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3Protiva P, Pendyala S, Nelson C, Augenlicht LH, Lipkin M, Holt PR. Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3. American Journal Of Clinical Nutrition 2016, 103: 1224-1231. PMID: 27009752, PMCID: PMC4841933, DOI: 10.3945/ajcn.114.105304.
• Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in MenClark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 2015, 150: 396-405. PMID: 26439436, PMCID: PMC4728019, DOI: 10.1053/j.gastro.2015.09.041.
• Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the LiverProtiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C. Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. Cellular And Molecular Gastroenterology And Hepatology 2015, 1: 535-549.e14. PMID: 26473164, PMCID: PMC4604042, DOI: 10.1016/j.jcmgh.2015.06.006.
• Mo1484 Endoscopic Ultrasound (EUS) Is Superior to Esophagogastroduodenoscopy (EGD) and Esophageal Capsule Endoscopy (ECE) for Varices ScreeningAbdi T, Marino D, Imaeda A, Chung C, Protiva P, Nagar A. Mo1484 Endoscopic Ultrasound (EUS) Is Superior to Esophagogastroduodenoscopy (EGD) and Esophageal Capsule Endoscopy (ECE) for Varices Screening. Gastrointestinal Endoscopy 2015, 81: ab437. DOI: 10.1016/j.gie.2015.03.814.
• Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid HepatotoxicityHayashi P, Fontana R, Chalasani N, Stolz A, Talwalkar J, Navarro V, Lee W, Davern T, Kleiner D, Gu J, Hoofnagle J, Investigators D, Chalasani N, Vuppalanchi R, Molleston J, Lumeng L, Corne A, Plummer A, Bonkovsky H, Protiva P, Freston J, Rosson R, Levine R, Maliakkal B, Appleton P, Smialek M, Fontana R, Conjeevaram H, Moseley R, Gordon S, Welch S, Worley J, Kridler J, Trivedi S, Kochlar S, Watkins P, Hayashi P, Russo M, Guess H, Beaver K, Smith A, Lewis J, Pusek S, Russell T, Mehltretter L, Davern T, Bonacini M, Partovi K, Fajardo K, Tai S, Lee W, Rockey D, Larson A, Grant L, Landgraf K, Stoltz A, Kaplowitz N, Milstein S, Talwalker J, Johnson S, Navarro V, Reddy R, Vega M, Wirjosemito A, Evans K, Rochon J, McHutchison J, Tilllmann H, Maggio M, Yang H, Galan K, Cosslin E, Sunas L, Collini M, Rose T, Crowder M, Scharenbroich C, Rostami H, Jiezhun S, Monroe T, Hammett A, Rosado N, Serrano J, Seeff L, Hoofnagle J, Toke D, Witt D, Higgins H, Kleiner D, Avigan M, Senior J. Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity. Clinical Gastroenterology And Hepatology 2015, 13: 1676-1682.e1. PMID: 25724701, PMCID: PMC4653068, DOI: 10.1016/j.cgh.2015.02.024.
• Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ MiceKadaveru K, Protiva P, Greenspan EJ, Kim YI, Rosenberg DW. Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice. Cancer Prevention Research 2012, 5: 911-920. PMID: 22677908, PMCID: PMC3397832, DOI: 10.1158/1940-6207.capr-11-0544.
• Abstract LB-182: Effects of methyl donor status on intestinal tumorigenesis in ApcMin/+ miceKadaveru K, Protiva P, Greenspan E, Kim Y, Rosenberg D. Abstract LB-182: Effects of methyl donor status on intestinal tumorigenesis in ApcMin/+ mice. Cancer Research 2012, 72: lb-182-lb-182. DOI: 10.1158/1538-7445.am2012-lb-182.
• Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopyAnderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, Rajan TV, Heinen CD, Levine JB, Rosenberg DW. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes & Control 2011, 23: 355-361. PMID: 22187142, DOI: 10.1007/s10552-011-9884-7.
• Risk Factors for Sessile Serrated AdenomasAnderson JC, Rangasamy P, Rustagi T, Myers M, Sanders M, Vaziri H, Wu G, Birk JW, Protiva P. Risk Factors for Sessile Serrated Adenomas. Journal Of Clinical Gastroenterology 2011, 45: 694-699. PMID: 21325950, DOI: 10.1097/mcg.0b013e318207f3cf.
• Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver InjuryDavern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH, Network D. Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury. Gastroenterology 2011, 141: 1665-1672.e9. PMID: 21855518, PMCID: PMC3654540, DOI: 10.1053/j.gastro.2011.07.051.
• Altered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal CarcinogenesisProtiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR. Altered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis. Cancer Prevention Research 2011, 4: 530-543. PMID: 21321062, PMCID: PMC3742550, DOI: 10.1158/1940-6207.capr-10-0143.
• Colorectal Cancer PathwaysProtiva P. Colorectal Cancer Pathways. 2011, 1-6. DOI: 10.1007/978-1-60761-398-5_1.
• ChemopreventionSingerman J, Protiva P. Chemoprevention. 2011, 187-200. DOI: 10.1007/978-1-60761-398-5_12.
• T1178 Folic Acid Supplementation Alters Expression of Genes Regulating 1-Carbon Metabolism and Inflammation in the Human Rectosigmoid MucosaProtiva P, Mason J, Liu Z, Hopkins M, Nelson C, Lambrecht R, Marshall J, Kopelovich L, Lipkin M, Holt P. T1178 Folic Acid Supplementation Alters Expression of Genes Regulating 1-Carbon Metabolism and Inflammation in the Human Rectosigmoid Mucosa. Gastroenterology 2010, 138: s-505. DOI: 10.1016/s0016-5085(10)62333-5.
• M1183 Modulation by Calcium of Vitamin D Induced Molecular Changes in the Human Rectosigmoid ColonHolt P, Pendyala S, Protiva P, Augenlicht L. M1183 Modulation by Calcium of Vitamin D Induced Molecular Changes in the Human Rectosigmoid Colon. Gastroenterology 2010, 138: s-349. DOI: 10.1016/s0016-5085(10)61609-5.
• Aberrant Crypt Foci and Tobacco Use: The Smoking Gun For Serrated Adenomas?Anderson J, Pleau D, Protiva P, Rajan T, Brenner B, Rosenberg D. Aberrant Crypt Foci and Tobacco Use: The Smoking Gun For Serrated Adenomas? The American Journal Of Gastroenterology 2009, 104: s559. DOI: 10.14309/00000434-200910003-01486.
• S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI NetworkBonkovsky H, Agrawal S, Fontana R, Chalasani N, Watkins P, Davern T, Serrano J, Protiva P, Boling J, Rochon J, Kleiner D. S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI Network. Gastroenterology 2009, 136: a-820. DOI: 10.1016/s0016-5085(09)63780-x.
• Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D ActivityProtiva P, Cross HS, Hopkins ME, Kállay E, Bises G, Dreyhaupt E, Augenlicht L, Lipkin M, Lesser M, Livote E, Holt PR. Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity. Cancer Prevention Research 2009, 2: 43-51. PMID: 19139017, DOI: 10.1158/1940-6207.capr-08-0103.
• Mechanistic studies on anticancer benzophenones from Clusiaceae fruitsKennelly E, Protiva P, Yang H, Baggett S, Weinstein B. Mechanistic studies on anticancer benzophenones from Clusiaceae fruits. Planta Medica 2008, 74 DOI: 10.1055/s-0028-1083968.
• Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injuryRochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG, Network D. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury. Hepatology 2008, 48: 1175-1183. PMID: 18798340, PMCID: PMC3618289, DOI: 10.1002/hep.22442.
• Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum responseProtiva P, Hopkins ME, Baggett S, Yang H, Lipkin M, Holt PR, Kennelly EJ, Bernard WI. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. International Journal Of Cancer 2008, 123: 687-694. PMID: 18470880, DOI: 10.1002/ijc.23515.
• T1781 N-Acetyl-L-Cysteine (NAC) Abrogates Changes in Cell Viability, Mitochondrial Potential and Gene Expression Caused By (-)-Epigallocatechin Gallate (EGCG) in a Human Liver (Huh7) Cell LineGrupka M, Lambrecht R, Protiva P. T1781 N-Acetyl-L-Cysteine (NAC) Abrogates Changes in Cell Viability, Mitochondrial Potential and Gene Expression Caused By (-)-Epigallocatechin Gallate (EGCG) in a Human Liver (Huh7) Cell Line. Gastroenterology 2008, 134: a-821. DOI: 10.1016/s0016-5085(08)63836-6.
• Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1. Journal Of Neuroscience 2007, 27: 12957-12966. PMID: 18032669, PMCID: PMC6673276, DOI: 10.1523/jneurosci.4142-07.2007.
• Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cellsAgarwal B, Swaroop P, Protiva P, Raj S, Shirin H, Holt P. Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells. Apoptosis 2003, 8: 649-654. PMID: 14739610, DOI: 10.1023/a:1026199929747.
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