Lynn Selemon, PhD
Research Scientist in Neuroscience
Research & Publications
Biography
News
Research Summary
My research is directed toward elucidating structural abnormalities in brain that are associated with neuropsychiatric illness, drug exposure, and aging. In particular, I am interested in the prefrontal cortex and its connections with other brain areas because the prefrontal cortex mediates higher brain function and has been strongly implicated in diseases such as schizophrenia and posttraumatic stress disorder.
Specialized Terms: Quantitative neuroanatomy; Schizophrenia; Dendritic morphology; Prefrontal cortex; Thalamus; Hippocampus; PTSD
Research Interests
Neuroanatomy; Neurobiology; Neurosciences; Schizophrenia; Thalamus; Prefrontal Cortex; Neuropsychiatry
Selected Publications
- BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controlsYoung KA, Thompson PM, Cruz DA, Williamson DE, Selemon LD. BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls Neurobiology Of Stress 2015, 2: 67-72. PMID: 26844242, PMCID: PMC4721476, DOI: 10.1016/j.ynstr.2015.07.002.
- Schizophrenia: a tale of two critical periods for prefrontal cortical developmentSelemon LD, Zecevic N. Schizophrenia: a tale of two critical periods for prefrontal cortical development Translational Psychiatry 2015, 5: e623-e623. PMID: 26285133, PMCID: PMC4564568, DOI: 10.1038/tp.2015.115.
- Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in SchizophreniaLi W, Ghose S, Gleason K, Begovic A, Perez J, Bartko J, Russo S, Wagner AD, Selemon L, Tamminga CA. Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in Schizophrenia American Journal Of Psychiatry 2015, 172: 373-382. PMID: 25585032, PMCID: PMC4457341, DOI: 10.1176/appi.ajp.2014.14010123.
- Frontal lobe synaptic plasticity in development and disease: modulation by the dopamine D1 receptor.Selemon LD. Frontal lobe synaptic plasticity in development and disease: modulation by the dopamine D1 receptor. Current Pharmaceutical Design 2014, 20: 5194-201. PMID: 24410560, DOI: 10.2174/1381612819666140110122307.
- Motor stereotypies and cognitive perseveration in non-human primates exposed to early gestational irradiationSelemon LD, Friedman HR. Motor stereotypies and cognitive perseveration in non-human primates exposed to early gestational irradiation Neuroscience 2013, 248: 213-224. PMID: 23769911, PMCID: PMC3823672, DOI: 10.1016/j.neuroscience.2013.06.006.
- A role for synaptic plasticity in the adolescent development of executive functionSelemon LD. A role for synaptic plasticity in the adolescent development of executive function Translational Psychiatry 2013, 3: e238-e238. PMID: 23462989, PMCID: PMC3625918, DOI: 10.1038/tp.2013.7.
- Distinct abnormalities of the primate prefrontal cortex caused by ionizing radiation in early or midgestationSelemon LD, Ceritoglu C, Ratnanather JT, Wang L, Harms MP, Aldridge K, Begović A, Csernansky JG, Miller MI, Rakic P. Distinct abnormalities of the primate prefrontal cortex caused by ionizing radiation in early or midgestation The Journal Of Comparative Neurology 2013, 521: 1040-1053. PMID: 22911497, PMCID: PMC3560314, DOI: 10.1002/cne.23217.
- Fetal Irradiation Interferes with Adult Cognition in the Nonhuman PrimateFriedman HR, Selemon LD. Fetal Irradiation Interferes with Adult Cognition in the Nonhuman Primate Biological Psychiatry 2010, 68: 108-111. PMID: 20399419, PMCID: PMC2900441, DOI: 10.1016/j.biopsych.2010.02.021.
- Reversal of neuronal and cognitive consequences of amphetamine sensitization following chronic treatment with a D1 antagonistSelemon LD, Begović A, Williams GV, Castner SA. Reversal of neuronal and cognitive consequences of amphetamine sensitization following chronic treatment with a D1 antagonist Pharmacology Biochemistry And Behavior 2010, 96: 325-332. PMID: 20600252, DOI: 10.1016/j.pbb.2010.06.002.