Lisa Leffert, MD
Research & Publications
Biography
News
Research Summary
The focus of Dr. Leffert’s clinical research has been to distill the existing evidence on critical comorbidities of pregnancy, convene interdisciplinary, national expert taskforces, conduct systematic reviews, and to produce consensus recommendations for high risk obstetric patients. While she has published on other topics, she is best known for her work on the management of obstetric patients with neurologic comorbidities or complications. After her initial work highlighting stroke in pregnancy, she focused on ensuring appropriate access to neuraxial anesthesia in obstetric patients by providing the “best available evidence” and decision algorithms for providers. Through systematic literature reviews and modified-Delphi processes, she has developed a methodology for creating and disseminating well-informed, practical guidance that is utilized nationally and internationally, despite limited available data. The SOAP anticoagulation and neuraxial procedure consensus statement (lead author) and the ASRA guidelines are go-to resources nationally and internationally. I recently initiated and led a similar joint venture between SOAP, the American College of Obstetricians and Gynecologists (ACOG), the Society for Maternal Fetal Medicine (SMFM), the American Society of Hematology (ASH) and ASRA on neuraxial procedures in thrombocytopenic obstetric patients (senior author). During the COVID-19 pandemic, she led the creation of a 17 center SOAP COVID-19 Delivery Registry of which she is P.I., to track peripartum obstetric, neonatal and anesthetic outcomes for affected parturients, a cohort with respiratory compromise in whom neuraxial anesthesia is particularly important.
Selected Publications
- The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United StatesKatz D, Bateman B, Kjaer K, Turner D, Spence N, Habib A, George R, Toledano R, Grant G, Madden H, Butwick A, Lynde G, Minehart R, Beilin Y, Houle T, Sharpe E, Kodali B, Bharadwaj S, Farber M, Palanisamy A, Prabhu M, Gonzales N, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Obstetric Anesthesia Digest 2022, 42: 27-28. DOI: 10.1097/01.aoa.0000816828.87126.61.
- ThrombophiliasToledano R, Leffert L. Thrombophilias. 2022, 313-316. DOI: 10.1007/978-3-030-72487-0_46.
- HaemophiliasToledano R, Leffert L. Haemophilias. 2022, 317-321. DOI: 10.1007/978-3-030-72487-0_47.
- Von Willebrand DiseaseCombs D, Leffert L. Von Willebrand Disease. 2022, 323-327. DOI: 10.1007/978-3-030-72487-0_48.
- Low Molecular Weight Heparin, Unfractionated Heparin and Neuraxial AnaesthesiaCombs D, Leffert L. Low Molecular Weight Heparin, Unfractionated Heparin and Neuraxial Anaesthesia. 2022, 329-335. DOI: 10.1007/978-3-030-72487-0_49.
- Investigating the Impact of Neuraxial Fentanyl on Results of Maternal and Neonatal Toxicology TestingSiegel M, Mahowald G, Uljon S, Leffert L, James K, Sullivan M, Hernandez S, Gray J, Schiff D, Bernstein S. Investigating the Impact of Neuraxial Fentanyl on Results of Maternal and Neonatal Toxicology Testing. American Journal Of Obstetrics And Gynecology 2022, 226: s23-s24. DOI: 10.1016/j.ajog.2021.11.084.
- Pragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular SystemWalsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular System. Obstetric Anesthesia Digest 2021, 41: 164-165. DOI: 10.1097/01.aoa.0000796068.53863.3d.
- Maternal StrokeMiller E, Leffert L. Maternal Stroke. 2020, 343-361. DOI: 10.1007/978-3-030-43477-9_25.
- Lumbar Neuraxial Procedures in Thrombocytopenic Patients Across Populations: A Systematic Review and Meta-analysisBauer M, Toledano R, Houle T, Beilin Y, MacEachern M, McCabe M, Rector D, Cooper J, Gernsheimer T, Landau R, Leffert L. Lumbar Neuraxial Procedures in Thrombocytopenic Patients Across Populations: A Systematic Review and Meta-analysis. Obstetric Anesthesia Digest 2020, 40: 118-118. DOI: 10.1097/01.aoa.0000693644.32975.42.
- Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control StudyBauer M, Housey M, Bauer S, Behrmann S, Chau A, Clancy C, Clark E, Einav S, Langen E, Leffert L, Lin S, Madapu M, Maile M, McQuaid-Hanson E, Priessnitz K, Sela H, Shah A, Sobolewski P, Toledo P, Tsen L, Bateman B. Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study. Obstetric Anesthesia Digest 2020, 40: 65-66. DOI: 10.1097/01.aoa.0000661332.57510.93.
- Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical ManagementNaoum E, Leffert L, Chitilian H, Gray K, Bateman B. Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical Management. Obstetric Anesthesia Digest 2019, 39: 179-180. DOI: 10.1097/01.aoa.0000603636.83263.e8.
- Don’t throw the baby out with the bathwater: spinal-epidural hematoma in the setting of obstetric thromboprophylaxis and neuraxial anesthesiaLeffert L, Horlocker T, Landau R. Don’t throw the baby out with the bathwater: spinal-epidural hematoma in the setting of obstetric thromboprophylaxis and neuraxial anesthesia. International Journal Of Obstetric Anesthesia 2019, 39: 7-11. PMID: 31202587, DOI: 10.1016/j.ijoa.2019.05.001.
- Intracranial Lesions in PregnancyToledano R, Leffert L. Intracranial Lesions in Pregnancy. 2019, 253-256. DOI: 10.1017/9781316155479.047.
- Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-based Guidelines (Fourth Edition)Horlocker T, Vandermeuelen E, Kopp S, Gogarten W, Leffert L, Benzon H. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-based Guidelines (Fourth Edition). Obstetric Anesthesia Digest 2019, 39: 28-29. DOI: 10.1097/01.aoa.0000552901.03545.fb.
- Update on Obstetric HemorrhageReale S, Leffert L, Farber M. Update on Obstetric Hemorrhage. Current Anesthesiology Reports 2019, 9: 60-68. DOI: 10.1007/s40140-019-00311-6.
- Anesthetic Management of Nonobstetric Surgery during Pregnancyd’Arby Toledano R, Madden H, Leffert L. Anesthetic Management of Nonobstetric Surgery during Pregnancy. Current Anesthesiology Reports 2019, 9: 31-38. DOI: 10.1007/s40140-019-00314-3.
- Abstract TP507: Sex-Related Differences in Neonatal Stroke: International Maternal Newborn Stroke RegistryLee S, Cavanaugh B, Kirton A, Mackay M, Leffert L, Fink M, Hernandez-Chavez M, Majersik J, Christudass C, Aaron S, Grefe A, Ostrander B, Bushnell C. Abstract TP507: Sex-Related Differences in Neonatal Stroke: International Maternal Newborn Stroke Registry. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.tp507.
- Acute Fatty Liver of PregnancyNaoum E, Leffert L, Chitilian H, Gray K, Bateman B. Acute Fatty Liver of Pregnancy. Anesthesiology 2019, 1. DOI: 10.1097/00000542-900000000-96683.
- Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low–Molecular-Weight HeparinLeffert L, Dubois H, Butwick A, Carvalho B, Houle T, Landau R. Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low–Molecular-Weight Heparin. Obstetric Anesthesia Digest 2018, 38: 3-4. DOI: 10.1097/01.aoa.0000529964.63597.d5.
- The Validity of Discharge Billing Codes Reflecting Severe Maternal MorbiditySigakis M, Leffert L, Mirzakhani H, Sharawi N, Rajala B, Callaghan W, Kuklina E, Creanga A, Mhyre J, Bateman B. The Validity of Discharge Billing Codes Reflecting Severe Maternal Morbidity. Obstetric Anesthesia Digest 2017, 37: 16-17. DOI: 10.1097/01.aoa.0000512008.03839.93.
- Anesthetic and Obstetric Management of Placenta Accreta: Clinical Experience and Available EvidenceToledano R, Leffert L. Anesthetic and Obstetric Management of Placenta Accreta: Clinical Experience and Available Evidence. Current Anesthesiology Reports 2017, 7: 93-102. DOI: 10.1007/s40140-017-0200-2.
- Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia PracticeLeffert L, Landau R. Integrating the New Thromboprophylaxis Guidelines Into Obstetric Anesthesia Practice. Survey Of Anesthesiology 2017, 61: 14. DOI: 10.1097/01.sa.0000513496.39516.43.
- 817: Shared decision-making for opioid prescribing after cesarean deliveryPrabhu M, McQuaid-Hanson E, Hopp S, Kaimal A, Leffert L, Bateman B. 817: Shared decision-making for opioid prescribing after cesarean delivery. American Journal Of Obstetrics And Gynecology 2017, 216: s469. DOI: 10.1016/j.ajog.2016.11.726.
- What’s New in Obstetric AnesthesiaLeffert L. What’s New in Obstetric Anesthesia. Survey Of Anesthesiology 2016, 60: 6-7. DOI: 10.1097/sa.0000000000000194.
- Opioid Abuse and Dependence During PregnancyMaeda A, Bateman B, Clancy C, Creanga A, Leffert L. Opioid Abuse and Dependence During Pregnancy. Obstetric Anesthesia Digest 2015, 35: 191-192. DOI: 10.1097/01.aoa.0000472709.26833.de.
- Hypertensive Disorders and Pregnancy-related StrokeLeffert L, Clancy C, Bateman B, Bryant A, Kuklina E. Hypertensive Disorders and Pregnancy-related Stroke. Obstetric Anesthesia Digest 2015, 35: 188-189. DOI: 10.1097/01.aoa.0000472706.03963.ac.
- Clinical Care for Opioid-using Pregnant and Postpartum WomenJones H, Deppen K, Hudak M, Leffert L, McClelland C, Sahin L, Starer J, Terplan M, Thorp J, Walsh J, Creanga A. Clinical Care for Opioid-using Pregnant and Postpartum Women. Obstetric Anesthesia Digest 2015, 35: 58-59. DOI: 10.1097/01.aoa.0000463802.46868.ed.
- Cardiac Arrest During Hospitalization for Delivery in the United States, 1998 to 2011Mhyre J, Tsen L, Einav S, Kuklina E, Leffert L, Bateman B. Cardiac Arrest During Hospitalization for Delivery in the United States, 1998 to 2011. Obstetric Anesthesia Digest 2015, 35: 75. DOI: 10.1097/01.aoa.0000463819.47761.37.
- What’s new in obstetric anesthesia? Focus on preeclampsiaLeffert L. What’s new in obstetric anesthesia? Focus on preeclampsia. International Journal Of Obstetric Anesthesia 2015, 24: 264-271. PMID: 25936785, DOI: 10.1016/j.ijoa.2015.03.008.
- Abstract 82: Patient and Hospital Characteristics of Pregnancy-Related Stroke from the Get With The Guidelines Stroke RegistryLeffert L, Clancy C, Bateman B, Cox M, Schulte P, Smith E, Fonarow G, Kuklina E, Schwamm L, George M. Abstract 82: Patient and Hospital Characteristics of Pregnancy-Related Stroke from the Get With The Guidelines Stroke Registry. Stroke 2015, 46 DOI: 10.1161/str.46.suppl_1.82.
- Abstract T P399: Patient Characteristics and Outcomes in Pregnancy-Related Subarachnoid HemorrhageLeffert L, Clancy C, Bateman B, Cox M, Schulte P, Smith E, Fonarow G, Schwamm L, George M, Kuklina E. Abstract T P399: Patient Characteristics and Outcomes in Pregnancy-Related Subarachnoid Hemorrhage. Stroke 2015, 46 DOI: 10.1161/str.46.suppl_1.tp399.
- Abstract 183: Use, Safety and Outcomes with Thrombolysis in Ischemic Stroke among Pregnant and Non-Pregnant WomenLeffert L, Clancy C, Bateman B, Cox M, Schulte P, Smith E, Fonarow G, Kuklina E, George M, Schwamm L. Abstract 183: Use, Safety and Outcomes with Thrombolysis in Ischemic Stroke among Pregnant and Non-Pregnant Women. Stroke 2015, 46 DOI: 10.1161/str.46.suppl_1.183.
- Abstract T MP43: Patient Characteristics and Outcomes in Pregnancy-Related Ischemic StrokeLeffert L, Clancy C, Bateman B, Cox M, Schulte P, Smith E, Fonarow G, Kuklina E, George M, Schwamm L. Abstract T MP43: Patient Characteristics and Outcomes in Pregnancy-Related Ischemic Stroke. Stroke 2015, 46 DOI: 10.1161/str.46.suppl_1.tmp43.
- Abstract T P319: Patient Characteristics and Outcomes in Pregnancy-Related Intracerebral HemorrhageLeffert L, Clancy C, Bateman B, Cox M, Schulte P, Smith E, Fonarow G, Schwamm L, George M, Kuklina E. Abstract T P319: Patient Characteristics and Outcomes in Pregnancy-Related Intracerebral Hemorrhage. Stroke 2015, 46 DOI: 10.1161/str.46.suppl_1.tp319.
- Focused ReviewHenke V, Bateman B, Leffert L. Focused Review. Obstetric Anesthesia Digest 2014, 34: 137-138. DOI: 10.1097/01.aoa.0000452148.42527.f2.
- Cardiac Arrest During Hospitalization for Delivery in the United States, 1998–2011Mhyre J, Tsen L, Einav S, Kuklina E, Leffert L, Bateman B. Cardiac Arrest During Hospitalization for Delivery in the United States, 1998–2011. Survey Of Anesthesiology 2014, 58: 181-182. DOI: 10.1097/01.sa.0000451418.67496.8a.
- Spinal Anesthesia in Severe PreeclampsiaHenke V, Bateman B, Leffert L. Spinal Anesthesia in Severe Preeclampsia. Survey Of Anesthesiology 2014, 58: 122-124. DOI: 10.1097/01.sa.0000446555.93217.63.
- Neuraxial Anesthesia in Parturients With Intracranial PathologyLeffert L, Schwamm L. Neuraxial Anesthesia in Parturients With Intracranial Pathology. Survey Of Anesthesiology 2014, 58: 122. DOI: 10.1097/sa.0000000000000049.
- The Association of Maternal Race and Ethnicity and the Risk of Postpartum HemorrhageBryant A, Mhyre J, Leffert L, Hoban R, Yakoob M, Bateman B. The Association of Maternal Race and Ethnicity and the Risk of Postpartum Hemorrhage. Obstetric Anesthesia Digest 2014, 34: 19. DOI: 10.1097/01.aoa.0000443356.48425.49.
- Peripartum Subarachnoid HemorrhageBateman B, Olbrecht V, Berman M, Minehart R, Schwamm L, Leffert L. Peripartum Subarachnoid Hemorrhage. Obstetric Anesthesia Digest 2013, 33: 21. DOI: 10.1097/01.aoa.0000426078.65994.96.
- Influence of Patient Comorbidities on the Risk of Near-Miss Maternal Morbidity or MortalityMhyre J, Bateman B, Leffert L. Influence of Patient Comorbidities on the Risk of Near-Miss Maternal Morbidity or Mortality. Obstetric Anesthesia Digest 2012, 32: 212-213. DOI: 10.1097/01.aoa.0000422690.35910.a1.
- Peripartum Subarachnoid HemorrhageBateman B, Olbrecht V, Berman M, Minehart R, Schwamm L, Leffert L. Peripartum Subarachnoid Hemorrhage. Survey Of Anesthesiology 2012, 56: 294-295. DOI: 10.1097/01.sa.0000422028.34250.1e.
- Influence of Patient Co-Morbidities on the Risk of Near-Miss Maternal Morbidity or MortalityMhyre J, Bateman B, Leffert L. Influence of Patient Co-Morbidities on the Risk of Near-Miss Maternal Morbidity or Mortality. Survey Of Anesthesiology 2012, 56: 180-181. DOI: 10.1097/01.sa.0000415537.66454.42.
- Association of Epidural-related Fever and Noninfectious Inflammation in Term LaborRiley L, Celi A, Onderdonk A, Roberts D, Johnson L, Tsen L, Leffert L, Pian-Smith M, Heffner L, Haas S, Lieberman E. Association of Epidural-related Fever and Noninfectious Inflammation in Term Labor. Obstetric Anesthesia Digest 2012, 32: 110-111. DOI: 10.1097/01.aoa.0000414090.52839.ff.
- Outcomes of Hospitalization in Pregnant Women with Brain Tumors: A Population-Based Study (P07.112)Terry A, Barker F, Leffert L, Bateman B, Souter I, Plotkin S. Outcomes of Hospitalization in Pregnant Women with Brain Tumors: A Population-Based Study (P07.112). Neurology 2012, 78: p07.112-p07.112. DOI: 10.1212/wnl.78.1_meetingabstracts.p07.112.
- Peripartum Subarachnoid HemorrhageBateman B, Olbrecht V, Berman M, Minehart R, Schwamm L, Leffert L. Peripartum Subarachnoid Hemorrhage. Anesthesiology 2012, 116: 324-333. PMID: 22166951, DOI: 10.1097/aln.0b013e3182410b22.
- Influence of Patient Comorbidities on the Risk of Near-miss Maternal Morbidity or MortalityMhyre J, Bateman B, Leffert L. Influence of Patient Comorbidities on the Risk of Near-miss Maternal Morbidity or Mortality. Anesthesiology 2011, 115: 963-972. PMID: 21934482, DOI: 10.1097/aln.0b013e318233042d.
- Substance abuse and anesthesiaGraetz T, Leffert L. Substance abuse and anesthesia. 2011, 88-94. DOI: 10.1017/cbo9780511842306.016.
- Obstetric hemorrhageGauran C, Leffert L. Obstetric hemorrhage. 2011, 757-760. DOI: 10.1017/cbo9780511842306.125.
- PreeclampsiaOrtman A, Leffert L. Preeclampsia. 2011, 761-765. DOI: 10.1017/cbo9780511842306.126.
- The Epidemiology of Postpartum Hemorrhage in a Large, Nationwide Sample of DeliveriesBateman B, Berman M, Riley L, Leffert L. The Epidemiology of Postpartum Hemorrhage in a Large, Nationwide Sample of Deliveries. Obstetric Anesthesia Digest 2011, 31: 89. DOI: 10.1097/01.aoa.0000397118.20085.45.
- Clinical Implications of Neuraxial Anesthesia in the Parturient With ScoliosisKo J, Leffert L. Clinical Implications of Neuraxial Anesthesia in the Parturient With Scoliosis. Obstetric Anesthesia Digest 2011, 31: 53-54. DOI: 10.1097/01.aoa.0000393190.66961.ef.
- In ResponseKo J, Leffert L. In Response. Anesthesia & Analgesia 2010, 111: 822. DOI: 10.1213/ane.0b013e3181e638b0.
- Management of a parturient with high-grade osteosarcoma of the proximal femur: a multidisciplinary approachQuaye A, Raskin K, Ecker J, Leffert L. Management of a parturient with high-grade osteosarcoma of the proximal femur: a multidisciplinary approach. International Journal Of Obstetric Anesthesia 2010, 19: 340-342. PMID: 20627530, DOI: 10.1016/j.ijoa.2010.03.013.
- Chapter 53 Substance AbuseLeffert L. Chapter 53 Substance Abuse. 2009, 1125-1147. DOI: 10.1016/b978-0-323-05541-3.00053-3.
- 833: Non-invasive cardiovascular profiling: Differences between patients with preeclampsia and those with gestational hypertensionKatz D, Ecker J, Leffert L, Pian-Smith M. 833: Non-invasive cardiovascular profiling: Differences between patients with preeclampsia and those with gestational hypertension. American Journal Of Obstetrics And Gynecology 2008, 199: s235. DOI: 10.1016/j.ajog.2008.09.864.
- PrefacePian-Smith M, Leffert L. Preface. 2007, xxi-xxii. DOI: 10.1017/cbo9780511586057.001.
- Is Bilateral Cerebral Subdural Hematoma More Frequent after Epidural Anesthesia than Spinal Anesthesia?Mashour G, Leffert L. Is Bilateral Cerebral Subdural Hematoma More Frequent after Epidural Anesthesia than Spinal Anesthesia? Anesthesiology 2006, 105: 1278. DOI: 10.1097/00000542-200612000-00033.
- ENDOTHELIAL DYSFUNCTION IN PREECLAMPSIA: A PILOT STUDY WITH NON-INVASIVE BLOOD PRESSURE WAVEFORM ANALYSISPianSmith M, Ecker J, Hsu K, Leffert L. ENDOTHELIAL DYSFUNCTION IN PREECLAMPSIA: A PILOT STUDY WITH NON-INVASIVE BLOOD PRESSURE WAVEFORM ANALYSIS. Anesthesiology 2002, 96: &na;. DOI: 10.1097/00000542-200204001-00013.