Joseph Santos-Sacchi, PhD
Research & Publications
Biography
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Research Summary
The exquisite sensitivity and frequency resolving power of the mammalian inner ear depends upon interactions between the two receptor cells of the organ of Corti, inner (IHC) and outer (OHC) hair cells. While inner hair cells appear to function solely as receptors of acoustic information, OHC’s function both as receptors and effectors, producing motile responses as a function of transmembrane potential fluctuations.
These motile responses modify the mechanical input to the inner hair cells which receive the majority of afferent innervation, thereby enhancing the gross frequency tuning afforded by basilar membrane mechanics. Dr. Joseph Santos-Sacchi studies the effector role of the OHC with electrophysiological (patch clamp) and displacement measurement techniques using isolated OHCs from the guinea pig. He also works on the motor protein (prestin) responsible for the cells’ mechanical activity, utilizing mutational analysis and expression systems to understand how it works.
Specialized Terms: Mammalian inner ear
Coauthors
Research Interests
Hair Cells, Auditory; Ear, Inner; Neurosciences; Otolaryngology; Physiology
Selected Publications
- Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative StressTan W, Santos-Sacchi J, Tonello J, Shanker A, Ivanova A. Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress. Antioxidants 2023, 12: 1225. PMCID: PMC10294946, DOI: 10.3390/antiox12061225.
- Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.Santos-Sacchi J, Bai J, Navaratnam D. Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification. Journal Of Neuroscience 2023, 43: 2460-2468. PMID: 36868859, PMCID: PMC10082455, DOI: 10.1523/jneurosci.2033-22.2023.
- Outer hair cell function is normal in βV spectrin knockout miceStankewich MC, Bai JP, Stabach PR, Khan S, Tan WJT, Surguchev A, Song L, Morrow JS, Santos-Sacchi J, Navaratnam DS. Outer hair cell function is normal in βV spectrin knockout mice. Hearing Research 2022, 423: 108564. PMID: 35864018, DOI: 10.1016/j.heares.2022.108564.
- On the frequency response of prestin charge movement in membrane patchesSantos-Sacchi J, Tan W. On the frequency response of prestin charge movement in membrane patches. Biophysical Journal 2022, 121: 2371-2379. PMID: 35598044, PMCID: PMC9279172, DOI: 10.1016/j.bpj.2022.05.020.
- Physiology and biophysics of outer hair cells: The cells of DallosSantos-Sacchi J, Navaratnam D. Physiology and biophysics of outer hair cells: The cells of Dallos. Hearing Research 2022, 423: 108525. PMID: 35599199, DOI: 10.1016/j.heares.2022.108525.
- Single particle cryo-EM structure of the outer hair cell motor protein prestinButan C, Song Q, Bai JP, Tan WJT, Navaratnam D, Santos-Sacchi J. Single particle cryo-EM structure of the outer hair cell motor protein prestin. Nature Communications 2022, 13: 290. PMID: 35022426, PMCID: PMC8755724, DOI: 10.1038/s41467-021-27915-z.
- Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating pointSantos-Sacchi J, Tan WJT. Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point. Hearing Research 2021, 423: 108373. PMID: 34776274, PMCID: PMC9054947, DOI: 10.1016/j.heares.2021.108373.
- Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochleaXue N, Song L, Song Q, Santos-Sacchi J, Wu H, Navaratnam D. Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea. Hearing Research 2021, 410: 108347. PMID: 34536825, DOI: 10.1016/j.heares.2021.108347.
- The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biologyBuffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño‐Enríquez M, Bronner GN, Coen C, Delaney MA, Dengler‐Crish C, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Hardell K, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O'Connor TP, Okanoya K, O'Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos‐Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, St. John Smith E. The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology. Biological Reviews 2021, 97: 115-140. PMID: 34476892, PMCID: PMC9277573, DOI: 10.1111/brv.12791.
- State dependent effects on the frequency response of prestin’s real and imaginary components of nonlinear capacitanceSantos-Sacchi J, Navaratnam D, Tan WJT. State dependent effects on the frequency response of prestin’s real and imaginary components of nonlinear capacitance. Scientific Reports 2021, 11: 16149. PMID: 34373481, PMCID: PMC8352928, DOI: 10.1038/s41598-021-95121-4.
- Efferent feedback controls bilateral auditory spontaneous activityWang Y, Sanghvi M, Gribizis A, Zhang Y, Song L, Morley B, Barson DG, Santos-Sacchi J, Navaratnam D, Crair M. Efferent feedback controls bilateral auditory spontaneous activity. Nature Communications 2021, 12: 2449. PMID: 33907194, PMCID: PMC8079389, DOI: 10.1038/s41467-021-22796-8.
- Animal Models for Otolaryngological DisordersDoukas S, Bartoshuk L, Manes R, Michaelides E, Santos-Sacchi J, Spock T, Sukys J, Sasaki C. Animal Models for Otolaryngological Disorders. 2021, 775-796. DOI: 10.1201/9780429439964-34.
- Comprehensive somatosensory and neurological phenotyping of NCS1 knockout miceNguyen LD, Nolte LG, Tan WJT, Giuvelis D, Santos-Sacchi J, Bilsky E, Ehrlich BE. Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice. Scientific Reports 2021, 11: 2372. PMID: 33504822, PMCID: PMC7840744, DOI: 10.1038/s41598-021-81650-5.
- Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-RatsPyott SJ, van Tuinen M, Screven LA, Schrode KM, Bai JP, Barone CM, Price SD, Lysakowski A, Sanderford M, Kumar S, Santos-Sacchi J, Lauer AM, Park TJ. Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats. Current Biology 2020, 30: 4329-4341.e4. PMID: 32888484, PMCID: PMC8109146, DOI: 10.1016/j.cub.2020.08.035.
- Author Correction: Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of CortiBai JP, Navaratnam D, Santos-Sacchi J. Author Correction: Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti. Scientific Reports 2020, 10: 14401. PMID: 32848168, PMCID: PMC7449959, DOI: 10.1038/s41598-020-70538-5.
- Calcium‐induced calcium release in proximity to hair cell BK channels revealed by PKA activationBai J, Xue N, Lawal O, Nyati A, Santos‐Sacchi J, Navaratnam D. Calcium‐induced calcium release in proximity to hair cell BK channels revealed by PKA activation. Physiological Reports 2020, 8: e14449. PMID: 32748549, PMCID: PMC7399380, DOI: 10.14814/phy2.14449.
- Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tensionSantos-Sacchi J, Tan W. Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension. Scientific Reports 2020, 10: 6222. PMID: 32277153, PMCID: PMC7148382, DOI: 10.1038/s41598-020-63201-6.
- Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane InsertionZhai F, Song L, Bai JP, Dai C, Navaratnam D, Santos-Sacchi J. Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion. Neuroscience 2020, 431: 128-133. PMID: 32061780, PMCID: PMC8720582, DOI: 10.1016/j.neuroscience.2020.02.003.
- Cytomegalovirus infects the developing Organ of Corti in a mouse model of virally induced deafnessOrnaghi S, Bai J, Santos-Sacchi J, Navaratnam D, Vergani P, van den Pol A, Paidas M. Cytomegalovirus infects the developing Organ of Corti in a mouse model of virally induced deafness. American Journal Of Obstetrics And Gynecology 2019, 221: 695-696. DOI: 10.1016/j.ajog.2019.10.063.
- Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is BestSantos-Sacchi J, Tan W. Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best. IScience 2019, 22: 392-399. PMID: 31812809, PMCID: PMC6911985, DOI: 10.1016/j.isci.2019.11.036.
- Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of CortiBai JP, Navaratnam D, Santos-Sacchi J. Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti. Scientific Reports 2019, 9: 16460. PMID: 31712635, PMCID: PMC6848539, DOI: 10.1038/s41598-019-52965-1.
- Outer hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitanceSantos-Sacchi J, Iwasa KH, Tan W. Outer hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitance. The Journal Of General Physiology 2019, 151: 1369-1385. PMID: 31676485, PMCID: PMC6888751, DOI: 10.1085/jgp.201812280.
- Modulators of Kv3 potassium channels rescue the auditory function of Fragile X miceEl-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 potassium channels rescue the auditory function of Fragile X mice. Journal Of Neuroscience 2019, 39: 0839-18. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.
- The speed limit of outer hair cell electromechanical activitySantos-Sacchi J. The speed limit of outer hair cell electromechanical activity. HNO 2019, 67: 159-164. PMID: 30747242, DOI: 10.1007/s00106-019-0615-9.
- Seeing the long tail: A novel green fluorescent protein, SiriusGFP, for ultra long timelapse imagingZhong S, Rivera-Molina F, Rivetta A, Toomre D, Santos-Sacchi J, Navaratnam D. Seeing the long tail: A novel green fluorescent protein, SiriusGFP, for ultra long timelapse imaging. Journal Of Neuroscience Methods 2018, 313: 68-76. PMID: 30578868, PMCID: PMC9431725, DOI: 10.1016/j.jneumeth.2018.12.008.
- High frequency measures of OHC nonlinear capacitance (NLC) and their significance: Why measures stray away from predictionsSantos-Sacchi J. High frequency measures of OHC nonlinear capacitance (NLC) and their significance: Why measures stray away from predictions. AIP Conference Proceedings 2018, 1965: 060004. DOI: 10.1063/1.5038477.
- The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of PrestinSantos-Sacchi J, Tan W. The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin. Journal Of Neuroscience 2018, 38: 5495-5506. PMID: 29899032, PMCID: PMC6001036, DOI: 10.1523/jneurosci.0425-18.2018.
- 5: Valnoctamide rescues CMV-induced deafness in a murine modelOrnaghi S, Bai J, Navaratnam D, Santos-Sacchi J, Vergani P, van den Pol A, Paidas M. 5: Valnoctamide rescues CMV-induced deafness in a murine model. American Journal Of Obstetrics And Gynecology 2018, 218: s4-s5. DOI: 10.1016/j.ajog.2017.10.416.
- Prestin: Molecular Mechanisms Underlying Outer Hair Cell ElectromotilitySantos-Sacchi J, Navaratnam D, Raphael R, Oliver D. Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility. 2017, 62: 113-145. DOI: 10.1007/978-3-319-52073-5_5.
- Current carried by the Slc26 family member prestin does not flow through the transporter pathwayBai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D. Current carried by the Slc26 family member prestin does not flow through the transporter pathway. Scientific Reports 2017, 7: 46619. PMID: 28422190, PMCID: PMC5395958, DOI: 10.1038/srep46619.
- Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner EarTan WJ, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV. Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxidants And Redox Signaling 2017, 27: 489-509. PMID: 28135838, PMCID: PMC5564041, DOI: 10.1089/ars.2016.6851.
- Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium ChannelsLv C, Stewart WJ, Akanyeti O, Frederick C, Zhu J, Santos-Sacchi J, Sheets L, Liao JC, Zenisek D. Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels. Cell Reports 2016, 15: 2784-2795. PMID: 27292637, PMCID: PMC5334794, DOI: 10.1016/j.celrep.2016.05.045.
- A Walkthrough of Nonlinear Capacitance Measurement of Outer Hair CellsSong L, Santos-Sacchi J. A Walkthrough of Nonlinear Capacitance Measurement of Outer Hair Cells. 2016, 1427: 501-512. PMID: 27259945, DOI: 10.1007/978-1-4939-3615-1_28.
- Chloride Anions Regulate Kinetics but Not Voltage-Sensor Q max of the Solute Carrier SLC26a5Santos-Sacchi J, Song L. Chloride Anions Regulate Kinetics but Not Voltage-Sensor Q max of the Solute Carrier SLC26a5. Biophysical Journal 2016, 110: 2551-2561. PMID: 27276272, PMCID: PMC4906268, DOI: 10.1016/j.bpj.2016.05.002.
- Intracellular calcium affects prestin’s voltage operating point indirectly via turgor-induced membrane tensionSong L, Santos-Sacchi J. Intracellular calcium affects prestin’s voltage operating point indirectly via turgor-induced membrane tension. AIP Conference Proceedings 2015, 1703: 030009. DOI: 10.1063/1.4939324.
- Molecular and Cellular Mechanics (Part II): A moderated discussionSantos-Sacchi J. Molecular and Cellular Mechanics (Part II): A moderated discussion. AIP Conference Proceedings 2015, 1703: 030011. DOI: 10.1063/1.4939326.
- Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial DeafnessMcKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS. Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. American Journal Of Pathology 2015, 185: 3132-3140. PMID: 26552864, PMCID: PMC5801480, DOI: 10.1016/j.ajpath.2015.08.014.
- An Electrical Inspection of the Subsurface Cisternae of the Outer Hair CellSong L, Santos-Sacchi J. An Electrical Inspection of the Subsurface Cisternae of the Outer Hair Cell. Biophysical Journal 2015, 108: 568-577. PMID: 25650924, PMCID: PMC4317539, DOI: 10.1016/j.bpj.2014.12.010.
- Tyrosine motifs are required for prestin basolateral membrane targetingZhang Y, Moeini-Naghani I, Bai J, Santos-Sacchi J, Navaratnam DS. Tyrosine motifs are required for prestin basolateral membrane targeting. Biology Open 2015, 4: 197-205. PMID: 25596279, PMCID: PMC4365488, DOI: 10.1242/bio.201410629.
- An Un-Bleachable YFP-Based Chloride SensorZhong S, Navaratnam D, Santos-Sacchi J. An Un-Bleachable YFP-Based Chloride Sensor. Biophysical Journal 2015, 108: 312a. DOI: 10.1016/j.bpj.2014.11.1695.
- Chloride-driven Electromechanical Phase Lags at Acoustic Frequencies Are Generated by SLC26a5, the Outer Hair Cell Motor ProteinSantos-Sacchi J, Song L. Chloride-driven Electromechanical Phase Lags at Acoustic Frequencies Are Generated by SLC26a5, the Outer Hair Cell Motor Protein. Biophysical Journal 2014, 107: 126-133. PMID: 24988347, PMCID: PMC4119270, DOI: 10.1016/j.bpj.2014.05.018.
- A Genetically-Encoded YFP Sensor with Enhanced Chloride Sensitivity, Photostability and Reduced pH Interference Demonstrates Augmented Transmembrane Chloride Movement by Gerbil Prestin (SLC26a5)Zhong S, Navaratnam D, Santos-Sacchi J. A Genetically-Encoded YFP Sensor with Enhanced Chloride Sensitivity, Photostability and Reduced pH Interference Demonstrates Augmented Transmembrane Chloride Movement by Gerbil Prestin (SLC26a5). PLOS ONE 2014, 9: e99095. PMID: 24901231, PMCID: PMC4047046, DOI: 10.1371/journal.pone.0099095.
- Chloride and Salicylate Influence Prestin-dependent Specific Membrane Capacitance SUPPORT FOR THE AREA MOTOR MODEL* * This work was supported, in whole or in part, by National Institutes of Health Grant NIDCD DC00273 (to J. S. S.).Santos-Sacchi J, Song L. Chloride and Salicylate Influence Prestin-dependent Specific Membrane Capacitance SUPPORT FOR THE AREA MOTOR MODEL* * This work was supported, in whole or in part, by National Institutes of Health Grant NIDCD DC00273 (to J. S. S.). Journal Of Biological Chemistry 2014, 289: 10823-10830. PMID: 24554714, PMCID: PMC4036195, DOI: 10.1074/jbc.m114.549329.
- Charaterization of Calcium Current and Exocytosis in Zebrafish Lateral Line Hair Cells During DevelopmentLv C, Santos-Sacchi J, Zenisek D. Charaterization of Calcium Current and Exocytosis in Zebrafish Lateral Line Hair Cells During Development. Biophysical Journal 2014, 106: 597a. DOI: 10.1016/j.bpj.2013.11.3305.
- Role of Kv1.3 Potassium Channels in Auditory FunctionEl-Hassar L, Song L, Gazula V, Navaratnam D, Santos-Sacchi J, Kaczmarek L. Role of Kv1.3 Potassium Channels in Auditory Function. Biophysical Journal 2014, 106: 740a. DOI: 10.1016/j.bpj.2013.11.4076.
- IR Laser-Induced Perturbations of the Voltage-Dependent Solute Carrier Protein SLC26a5Okunade O, Santos-Sacchi J. IR Laser-Induced Perturbations of the Voltage-Dependent Solute Carrier Protein SLC26a5. Biophysical Journal 2013, 105: 1822-1828. PMID: 24138858, PMCID: PMC3797594, DOI: 10.1016/j.bpj.2013.09.008.
- Real Time Measures of Prestin Charge and Fluorescence during Plasma Membrane Trafficking Reveal Sub-Tetrameric ActivityBian S, Navaratnam D, Santos-Sacchi J. Real Time Measures of Prestin Charge and Fluorescence during Plasma Membrane Trafficking Reveal Sub-Tetrameric Activity. PLOS ONE 2013, 8: e66078. PMID: 23762468, PMCID: PMC3677934, DOI: 10.1371/journal.pone.0066078.
- Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5Song L, Santos-Sacchi J. Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3883-3888. PMID: 23431177, PMCID: PMC3593883, DOI: 10.1073/pnas.1218341110.
- Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living ZebrafishRicci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J. Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish. Journal Of Neuroscience 2013, 33: 3131-3134. PMID: 23407967, PMCID: PMC3684625, DOI: 10.1523/jneurosci.4265-12.2013.
- Removing pH-Sensitivity and Improving Photostability of a Genetically-Encoded Chloride SensorZhong S, Navaratnam D, Santos-Sacchi J. Removing pH-Sensitivity and Improving Photostability of a Genetically-Encoded Chloride Sensor. Biophysical Journal 2013, 104: 348a-349a. DOI: 10.1016/j.bpj.2012.11.1935.
- Chapter 25 AuditionBrown M, Santos-Sacchi J. Chapter 25 Audition. 2013, 553-576. DOI: 10.1016/b978-0-12-385870-2.00025-1.
- Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause DeafnessRaimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS. Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness. Cell 2012, 148: 716-726. PMID: 22341444, PMCID: PMC3285425, DOI: 10.1016/j.cell.2011.12.027.
- Chloride Flux in Prestin-Expressing CellsZhong S, Bian S, Navaratnam D, Santos-Sacchi J. Chloride Flux in Prestin-Expressing Cells. Biophysical Journal 2012, 102: 246a. DOI: 10.1016/j.bpj.2011.11.1355.
- Coupling Molecular Motions of Prestin to Cellular Motility: Effects of Voltage, Chloride and CytoskeletonSong L, Santos-Sacchi J. Coupling Molecular Motions of Prestin to Cellular Motility: Effects of Voltage, Chloride and Cytoskeleton. Biophysical Journal 2012, 102: 707a-708a. DOI: 10.1016/j.bpj.2011.11.3840.
- Evaluating Prestin's Changing Biophysical Attributes in Development Using a Tet‐Induced Cell LineBian S, Koo B, Kelleher S, Santos-Sacchi J, Navaratnam D, Shera C, Olson E. Evaluating Prestin's Changing Biophysical Attributes in Development Using a Tet‐Induced Cell Line. AIP Conference Proceedings 2011, 1403: 143-147. DOI: 10.1063/1.3658075.
- Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's OrganSong L, Santos-Sacchi J, Shera C, Olson E. Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's Organ. AIP Conference Proceedings 2011, 1403: 179-184. DOI: 10.1063/1.3658083.
- Tracking vesicle fusion from hair cell ribbon synapses using a high frequency, dual sine wave stimulus paradigmSchnee ME, Castellano-Muñoz M, Kong JH, Santos-Sacchi J, Ricci AJ. Tracking vesicle fusion from hair cell ribbon synapses using a high frequency, dual sine wave stimulus paradigm. Communicative & Integrative Biology 2011, 4: 785-787. PMID: 22446556, PMCID: PMC3306360, DOI: 10.4161/cib.17822.
- Corrigendum to “The remarkable cochlear amplifier” [Hear. Res. 266 (1–2) (2010) 1–17]Ashmore J, Avan P, Brownell W, Dallos P, Dierkes K, Fettiplace R, Grosh K, Hackney C, Hudspeth A, Jülicher F, Lindner B, Martin P, Meaud J, Petit C, Santos-Sacchi J, Canlon B. Corrigendum to “The remarkable cochlear amplifier” [Hear. Res. 266 (1–2) (2010) 1–17]. Hearing Research 2011, 280: 245. DOI: 10.1016/j.heares.2011.05.020.
- Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cellsLi X, Surguchev A, Bian S, Navaratnam D, Santos-Sacchi J. Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells. American Journal Of Physiology - Cell Physiology 2011, 302: c296-c306. PMID: 21940671, PMCID: PMC4054960, DOI: 10.1152/ajpcell.00177.2011.
- Calcium-Dependent Synaptic Vesicle Trafficking Underlies Indefatigable Release at the Hair Cell Afferent Fiber SynapseSchnee ME, Santos-Sacchi J, Castellano-Muñoz M, Kong JH, Ricci AJ. Calcium-Dependent Synaptic Vesicle Trafficking Underlies Indefatigable Release at the Hair Cell Afferent Fiber Synapse. Neuron 2011, 70: 326-338. PMID: 21521617, PMCID: PMC3254016, DOI: 10.1016/j.neuron.2011.01.031.
- Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory EpitheliumFrucht CS, Uduman M, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium. Journal Of The Association For Research In Otolaryngology 2011, 12: 423-435. PMID: 21399991, PMCID: PMC3123449, DOI: 10.1007/s10162-011-0259-2.
- MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epitheliumFrucht CS, Santos-Sacchi J, Navaratnam DS. MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium. Neuroscience Letters 2011, 493: 44-48. PMID: 21316421, PMCID: PMC3065390, DOI: 10.1016/j.neulet.2011.02.017.
- Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cellWu T, Song L, Shi X, Jiang Z, Santos-Sacchi J, Nuttall A. Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell. Hearing Research 2010, 272: 117-124. PMID: 21044673, PMCID: PMC3387680, DOI: 10.1016/j.heares.2010.10.010.
- Patch-clamp amplifiers on a chipWeerakoon P, Culurciello E, Yang Y, Santos-Sacchi J, Kindlmann PJ, Sigworth FJ. Patch-clamp amplifiers on a chip. Journal Of Neuroscience Methods 2010, 192: 187-192. PMID: 20637803, PMCID: PMC2978236, DOI: 10.1016/j.jneumeth.2010.06.030.
- A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational eventsBian S, Koo BW, Kelleher S, Santos-Sacchi J, Navaratnam DS. A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events. American Journal Of Physiology - Cell Physiology 2010, 299: c828-c835. PMID: 20631244, PMCID: PMC3774197, DOI: 10.1152/ajpcell.00182.2010.
- Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of ProliferationFrucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of Proliferation. PLOS ONE 2010, 5: e11502. PMID: 20634979, PMCID: PMC2901389, DOI: 10.1371/journal.pone.0011502.
- Combinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage SensingBai JP, Surguchev A, Bian S, Song L, Santos-Sacchi J, Navaratnam D. Combinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage Sensing. Biophysical Journal 2010, 99: 85-94. PMID: 20655836, PMCID: PMC2895379, DOI: 10.1016/j.bpj.2010.03.066.
- The remarkable cochlear amplifierAshmore J, Avan P, Brownell W, Dallos P, Dierkes K, Fettiplace R, Grosh K, Hackney C, Hudspeth A, Jülicher F, Lindner B, Martin P, Meaud J, Petit C, Santos-Sacchi J, Sacchi J, Canlon B. The remarkable cochlear amplifier. Hearing Research 2010, 266: 1-17. PMID: 20541061, PMCID: PMC6366996, DOI: 10.1016/j.heares.2010.05.001.
- An integrated patch-clamp system with dual InputWeerakoon P, Sigworth F, Kindlmann P, Santos-Sacchi J, Yang Y, Culurciello E. An integrated patch-clamp system with dual Input. 2005 IEEE International Symposium On Circuits And Systems (ISCAS) 2010, 1523-1526. DOI: 10.1109/iscas.2010.5537382.
- Prestin Surface Expression and Activity Are Augmented by Interaction with MAP1S, a Microtubule-associated Protein*Bai JP, Surguchev A, Ogando Y, Song L, Bian S, Santos-Sacchi J, Navaratnam D. Prestin Surface Expression and Activity Are Augmented by Interaction with MAP1S, a Microtubule-associated Protein*. Journal Of Biological Chemistry 2010, 285: 20834-20843. PMID: 20418376, PMCID: PMC2898336, DOI: 10.1074/jbc.m110.117853.
- Conformational State-Dependent Anion Binding in Prestin: Evidence for Allosteric ModulationSong L, Santos-Sacchi J. Conformational State-Dependent Anion Binding in Prestin: Evidence for Allosteric Modulation. Biophysical Journal 2010, 98: 371-376. PMID: 20141749, PMCID: PMC2814207, DOI: 10.1016/j.bpj.2009.10.027.
- A Two-Channel Patch-Clamp System on a ChipWeerakoon P, Culurciello E, Santos-Sacchi J, Yang Y, Sigworth F. A Two-Channel Patch-Clamp System on a Chip. Biophysical Journal 2010, 98: 603a. DOI: 10.1016/j.bpj.2009.12.3288.
- Prestin's Anion Transport and Voltage-Sensing Capabilities Are IndependentBai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D. Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent. Biophysical Journal 2009, 96: 3179-3186. PMID: 19383462, PMCID: PMC2718310, DOI: 10.1016/j.bpj.2008.12.3948.
- FIRING UP THE AMPLIFIER: TEMPERATURE, PRESSURE AND VOLTAGE JUMP STUDIES ON OHC MOTOR CAPACITANCESANTOS-SACCHI J, SONG L, LI X. FIRING UP THE AMPLIFIER: TEMPERATURE, PRESSURE AND VOLTAGE JUMP STUDIES ON OHC MOTOR CAPACITANCE. 2009, 363-370. DOI: 10.1142/9789812833785_0058.
- Fast Electromechanical Amplification in the Lateral Membrane of the Outer Hair CellSantos-Sacchi J, Navarrete E, Song L. Fast Electromechanical Amplification in the Lateral Membrane of the Outer Hair Cell. Biophysical Journal 2009, 96: 739-747. PMID: 19167318, PMCID: PMC2716482, DOI: 10.1016/j.bpj.2008.10.015.
- Anion Control of Voltage Sensing by the Motor Protein Prestin in Outer Hair CellsRybalchenko V, Santos-Sacchi J. Anion Control of Voltage Sensing by the Motor Protein Prestin in Outer Hair Cells. Biophysical Journal 2008, 95: 4439-4447. PMID: 18658219, PMCID: PMC2567960, DOI: 10.1529/biophysj.108.134197.
- Cochlear Mechanics: No Shout but a Twist in the Absence of PrestinSantos-Sacchi J. Cochlear Mechanics: No Shout but a Twist in the Absence of Prestin. Current Biology 2008, 18: r304-r306. PMID: 18397741, DOI: 10.1016/j.cub.2008.02.019.
- The still magnificent outer hair cellSantos-Sacchi J. The still magnificent outer hair cell. Otology Japan 2007, 17: 2-7. DOI: 10.11289/otoljpn1991.17.2.
- Developmental Expression of the Outer Hair Cell Motor Prestin in the MouseAbe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse. The Journal Of Membrane Biology 2007, 215: 49-56. PMID: 17415610, PMCID: PMC4154540, DOI: 10.1007/s00232-007-9004-5.
- CHLORIDE AND THE OHC LATERAL MEMBRANE MOTORSANTOS-SACCHI J, SONG L, BAI J, NAVARATNAM D. CHLORIDE AND THE OHC LATERAL MEMBRANE MOTOR. 2006, 162-168. DOI: 10.1142/9789812773456_0028.
- MANIPULATIONS OF CHLORIDE ION CONCENTRATION IN THE ORGAN OF CORTI ALTER OUTER HAIR CELL ELECTROMOTILITY AND COCHLEAR AMPLIFICATIONZHENG J, ZOU Y, NUTTALL A, SANTOS-SACCHI J. MANIPULATIONS OF CHLORIDE ION CONCENTRATION IN THE ORGAN OF CORTI ALTER OUTER HAIR CELL ELECTROMOTILITY AND COCHLEAR AMPLIFICATION. 2006, 107-108. DOI: 10.1142/9789812773456_0016.
- En block C-terminal charge cluster reversals in prestin (SLC26A5): Effects on voltage-dependent electromechanical activityBai JP, Navaratnam D, Samaranayake H, Santos-Sacchi J. En block C-terminal charge cluster reversals in prestin (SLC26A5): Effects on voltage-dependent electromechanical activity. Neuroscience Letters 2006, 404: 270-275. PMID: 16839688, DOI: 10.1016/j.neulet.2006.05.062.
- Control of Mammalian Cochlear Amplification by Chloride AnionsSantos-Sacchi J, Song L, Zheng J, Nuttall AL. Control of Mammalian Cochlear Amplification by Chloride Anions. Journal Of Neuroscience 2006, 26: 3992-3998. PMID: 16611815, PMCID: PMC6673883, DOI: 10.1523/jneurosci.4548-05.2006.
- On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestinSantos-Sacchi J, Rybalchenko V, Bai JP, Song L, Navaratnam D. On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin. Pflügers Archiv - European Journal Of Physiology 2006, 452: 283. PMID: 16521020, DOI: 10.1007/s00424-005-0037-2.
- Tuning in to the Amazing Outer Hair Cell: Membrane Wizardry with a Twist and ShoutHe D, Zheng J, Kalinec F, Kakehata S, Santos-Sacchi J. Tuning in to the Amazing Outer Hair Cell: Membrane Wizardry with a Twist and Shout. The Journal Of Membrane Biology 2006, 209: 119-134. PMID: 16773497, DOI: 10.1007/s00232-005-0833-9.
- Membranes and Their Interacting Partners in Peripheral Auditory FunctionSantos-Sacchi J. Membranes and Their Interacting Partners in Peripheral Auditory Function. The Journal Of Membrane Biology 2006, 209: 69-70. DOI: 10.1007/s00232-005-0855-3.
- On the Effect of Prestin on the Electrical Breakdown of Cell MembranesNavarrete EG, Santos-Sacchi J. On the Effect of Prestin on the Electrical Breakdown of Cell Membranes. Biophysical Journal 2005, 90: 967-974. PMID: 16299081, PMCID: PMC1367121, DOI: 10.1529/biophysj.105.064105.
- N-Terminal-Mediated Homomultimerization of Prestin, the Outer Hair Cell Motor ProteinNavaratnam D, Bai JP, Samaranayake H, Santos-Sacchi J. N-Terminal-Mediated Homomultimerization of Prestin, the Outer Hair Cell Motor Protein. Biophysical Journal 2005, 89: 3345-3352. PMID: 16113116, PMCID: PMC1366831, DOI: 10.1529/biophysj.105.068759.
- Glibenclamide Stimulates Fluid Secretion in Rodent Cholangiocytes Through a Cystic Fibrosis Transmembrane Conductance Regulator-Independent MechanismSpirlì C, Fiorotto R, Song L, Santos-Sacchi J, Okolicsanyi L, Masier S, Rocchi L, Vairetti MP, de Bernard M, Melero S, Pozzan T, Strazzabosco M. Glibenclamide Stimulates Fluid Secretion in Rodent Cholangiocytes Through a Cystic Fibrosis Transmembrane Conductance Regulator-Independent Mechanism. Gastroenterology 2005, 129: 220-233. PMID: 16012949, DOI: 10.1053/j.gastro.2005.03.048.
- On Membrane Motor Activity and Chloride Flux in the Outer Hair Cell: Lessons Learned from the Environmental Toxin TributyltinSong L, Seeger A, Santos-Sacchi J. On Membrane Motor Activity and Chloride Flux in the Outer Hair Cell: Lessons Learned from the Environmental Toxin Tributyltin. Biophysical Journal 2004, 88: 2350-2362. PMID: 15596517, PMCID: PMC1305283, DOI: 10.1529/biophysj.104.053579.
- Animal Models for Otolaryngological DisordersRoss D, Hundal J, Sasaki C, Bartoshuk L, Santos-Sacchi J, Schwartz I. Animal Models for Otolaryngological Disorders. 2004, 241-261. DOI: 10.1201/9781420039627.ch11.
- Determination of Cell Capacitance Using the Exact Empirical Solution of ∂Y/∂Cm and Its Phase AngleSantos-Sacchi J. Determination of Cell Capacitance Using the Exact Empirical Solution of ∂Y/∂Cm and Its Phase Angle. Biophysical Journal 2004, 87: 714-727. PMID: 15240504, PMCID: PMC1304394, DOI: 10.1529/biophysj.103.033993.
- Protein- and Lipid-Reactive Agents Alter Outer Hair Cell Lateral Membrane Motor Charge MovementSantos-Sacchi J, Wu M. Protein- and Lipid-Reactive Agents Alter Outer Hair Cell Lateral Membrane Motor Charge Movement. The Journal Of Membrane Biology 2004, 200: 83-92. PMID: 15520906, DOI: 10.1007/s00232-004-0699-2.
- New tunes from Corti’s organ: the outer hair cell boogie rulesSantos-Sacchi J. New tunes from Corti’s organ: the outer hair cell boogie rules. Current Opinion In Neurobiology 2003, 13: 459-468. PMID: 12965294, DOI: 10.1016/s0959-4388(03)00100-4.
- Excitation of fluorescent dyes inactivates the outer hair cell integral membrane motor protein prestin and betrays its lateral mobilitySantos-Sacchi J, Zhao HB. Excitation of fluorescent dyes inactivates the outer hair cell integral membrane motor protein prestin and betrays its lateral mobility. Pflügers Archiv - European Journal Of Physiology 2003, 446: 617-622. PMID: 12783229, DOI: 10.1007/s00424-003-1053-8.
- ALLOSTERIC MODULATION OF THE OUTER HAIR CELL MOTOR PROTEIN PRESTIN BY CHLORIDERYBALCHENKO V, SANTOS-SACCHI J. ALLOSTERIC MODULATION OF THE OUTER HAIR CELL MOTOR PROTEIN PRESTIN BY CHLORIDE. 2003, 116-126. DOI: 10.1142/9789812704931_0015.
- Cl− flux through a non‐selective, stretch‐sensitive conductance influences the outer hair cell motor of the guinea‐pigRybalchenko V, Santos‐Sacchi J. Cl− flux through a non‐selective, stretch‐sensitive conductance influences the outer hair cell motor of the guinea‐pig. The Journal Of Physiology 2003, 547: 873-891. PMID: 12562920, PMCID: PMC2342734, DOI: 10.1111/j.1469-7793.2003.00873.x.
- Functional motor microdomains of the outer hair cell lateral membraneSantos-Sacchi J. Functional motor microdomains of the outer hair cell lateral membrane. Pflügers Archiv - European Journal Of Physiology 2002, 445: 331-336. PMID: 12466934, DOI: 10.1007/s00424-002-0928-4.
- Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motorSantos-Sacchi J, Navarrete E. Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor. Pflügers Archiv - European Journal Of Physiology 2002, 444: 99-106. PMID: 11976921, DOI: 10.1007/s00424-002-0804-2.
- Temperature dependence of non-linear capacitance in human embryonic kidney cells transfected with prestin, the outer hair cell motor proteinMeltzer J, Santos-Sacchi J. Temperature dependence of non-linear capacitance in human embryonic kidney cells transfected with prestin, the outer hair cell motor protein. Neuroscience Letters 2001, 313: 141-144. PMID: 11682147, DOI: 10.1016/s0304-3940(01)02266-2.
- Furosemide alters nonlinear capacitance in isolated outer hair cellsSantos-Sacchi J, Wu M, Kakehata S. Furosemide alters nonlinear capacitance in isolated outer hair cells. Hearing Research 2001, 159: 69-73. PMID: 11520635, DOI: 10.1016/s0378-5955(01)00321-5.
- Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor proteinSantos‐Sacchi J, Shen W, Zheng J, Dallos P. Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein. The Journal Of Physiology 2001, 531: 661-666. PMID: 11251048, PMCID: PMC2278494, DOI: 10.1111/j.1469-7793.2001.0661h.x.
- Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membraneTakahashi S, Santos-Sacchi J. Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane. Pflügers Archiv - European Journal Of Physiology 2001, 441: 506-513. PMID: 11212214, DOI: 10.1007/s004240000455.
- Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organBlasits S, Maune S, Santos-Sacchi J. Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ. Pflügers Archiv - European Journal Of Physiology 2000, 440: 710-712. PMID: 11007311, DOI: 10.1007/s004240000355.
- Voltage Gating of Gap Junctions in Cochlear Supporting Cells: Evidence for Nonhomotypic ChannelsZhao H, Santos-Sacchi J. Voltage Gating of Gap Junctions in Cochlear Supporting Cells: Evidence for Nonhomotypic Channels. The Journal Of Membrane Biology 2000, 175: 17-24. PMID: 10811964, DOI: 10.1007/s002320001051.
- Cell coupling in Corti's organSantos-Sacchi J. Cell coupling in Corti's organ. Brain Research Reviews 2000, 32: 167-171. PMID: 10751666, DOI: 10.1016/s0165-0173(99)00077-6.
- Distortion Component Analysis of Outer Hair Cell Motility-Related Gating ChargeTakahashi S, Santos-Sacchi J. Distortion Component Analysis of Outer Hair Cell Motility-Related Gating Charge. The Journal Of Membrane Biology 1999, 169: 199-207. PMID: 10354466, DOI: 10.1007/s002329900531.
- The magnificent outer hair cell of Corti's organSantos-Sacchi J. The magnificent outer hair cell of Corti's organ. Otology Japan 1999, 9: 111-115. DOI: 10.11289/otoljpn1991.9.111.
- Auditory collusion and a coupled couple of outer hair cellsZhao H, Santos-Sacchi J. Auditory collusion and a coupled couple of outer hair cells. Nature 1999, 399: 359-362. PMID: 10360573, DOI: 10.1038/20686.
- Density of motility-related charge in the outer hair cell of the guinea pig is inversely related to best frequencySantos-Sacchi J, Kakehata S, Kikuchi T, Katori Y, Takasaka T. Density of motility-related charge in the outer hair cell of the guinea pig is inversely related to best frequency. Neuroscience Letters 1998, 256: 155-158. PMID: 9855363, DOI: 10.1016/s0304-3940(98)00788-5.
- Effects of Lipophilic Ions on Outer Hair Cell Membrane Capacitance and MotilityWu M, Santos-Sacchi J. Effects of Lipophilic Ions on Outer Hair Cell Membrane Capacitance and Motility. The Journal Of Membrane Biology 1998, 166: 111-118. PMID: 9841736, DOI: 10.1007/s002329900453.
- Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's OrganZhao H, Santos-Sacchi J. Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ. The Journal Of General Physiology 1998, 112: 447-455. PMID: 9758863, PMCID: PMC2229429, DOI: 10.1085/jgp.112.4.447.
- Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pigSantos‐Sacchi J, Kakehata S, Takahashi S. Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig. The Journal Of Physiology 1998, 510: 225-235. PMID: 9625879, PMCID: PMC2231020, DOI: 10.1111/j.1469-7793.1998.225bz.x.
- Temperature dependence of outer hair cell nonlinear capacitanceSantos-Sacchi J, Huang G. Temperature dependence of outer hair cell nonlinear capacitance. Hearing Research 1998, 116: 99-106. PMID: 9508032, DOI: 10.1016/s0378-5955(97)00204-9.
- Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputationSantos-Sacchi J, Huang GJ, Wu M. Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation. Biophysical Journal 1997, 73: 1424-1429. PMID: 9284309, PMCID: PMC1181041, DOI: 10.1016/s0006-3495(97)78174-8.
- Membrane-bound voltage sensor-motor elements contrl OHC lengthKakehata S, Santos-Sacchi J, Takasaka T. Membrane-bound voltage sensor-motor elements contrl OHC length. Otology Japan 1997, 7: 92-96. DOI: 10.11289/otoljpn1991.7.92.
- Cochlear Mechanics and BiophysicsRuggero M, Santos‐Sacchi J. Cochlear Mechanics and Biophysics. 1997, 1357-1369. DOI: 10.1002/9780470172537.ch108.
- Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating ChargeKakehata S, Santos-Sacchi J. Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge. Journal Of Neuroscience 1996, 16: 4881-4889. PMID: 8756420, PMCID: PMC6579298, DOI: 10.1523/jneurosci.16-16-04881.1996.
- Midinfrared ablation of dentin with the Vanderbilt FELHarris D, Reinisch L, Edwards G, Yessik M, Ashrafi S, Santos-Sacchi J. Midinfrared ablation of dentin with the Vanderbilt FEL. Proceedings Of SPIE 1996, 2672: 165-175. DOI: 10.1117/12.238765.
- Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.Hasson T, Heintzelman M, Santos-Sacchi J, Corey D, Mooseker M. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 9815-9819. PMID: 7568224, PMCID: PMC40893, DOI: 10.1073/pnas.92.21.9815.
- Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating chargeKakehata S, Santos-Sacchi J. Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge. Biophysical Journal 1995, 68: 2190-2197. PMID: 7612863, PMCID: PMC1282124, DOI: 10.1016/s0006-3495(95)80401-7.
- Laser selective microablation of sensitized intracellular components within auditory receptor cellsHarris D, Evans B, Santos-Sacchi J. Laser selective microablation of sensitized intracellular components within auditory receptor cells. Proceedings Of SPIE 1995, 2396: 260-265. DOI: 10.1117/12.208412.
- Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane.Huang G, Santos-Sacchi J. Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 12268-12272. PMID: 7991617, PMCID: PMC45418, DOI: 10.1073/pnas.91.25.12268.
- Cell coupling in the supporting cells of Corti's organ: Sensitivity to intracellular H+ and Ca+2Sato Y, Santos-Sacchi J. Cell coupling in the supporting cells of Corti's organ: Sensitivity to intracellular H+ and Ca+2. Hearing Research 1994, 80: 21-24. PMID: 7852199, DOI: 10.1016/0378-5955(94)90004-3.
- Variability of voltage dependency of the outer hair cell (OHC) motility voltage sensorSantos‐Sacchi J, Huang G, Kakehata S. Variability of voltage dependency of the outer hair cell (OHC) motility voltage sensor. The Journal Of The Acoustical Society Of America 1994, 95: 2841-2841. DOI: 10.1121/1.409615.
- Harmonics of outer hair cell motilitySantos-Sacchi J. Harmonics of outer hair cell motility. Biophysical Journal 1993, 65: 2217-2227. PMID: 8298045, PMCID: PMC1225953, DOI: 10.1016/s0006-3495(93)81247-5.
- Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputationHuang G, Santos-Sacchi J. Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputation. Biophysical Journal 1993, 65: 2228-2236. PMID: 8298046, PMCID: PMC1225954, DOI: 10.1016/s0006-3495(93)81248-7.
- Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner earSantos-Sacchi J. Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear. Journal Of Neuroscience 1993, 13: 3599-3611. PMID: 8393487, PMCID: PMC6576533, DOI: 10.1523/jneurosci.13-08-03599.1993.
- On the frequency limit and phase of outer hair cell motility: effects of the membrane filterSantos-Sacchi J. On the frequency limit and phase of outer hair cell motility: effects of the membrane filter. Journal Of Neuroscience 1992, 12: 1906-1916. PMID: 1578277, PMCID: PMC6575887, DOI: 10.1523/jneurosci.12-05-01906.1992.
- Reversible inhibition of voltage-dependent outer hair cell motility and capacitanceSantos-Sacchi J. Reversible inhibition of voltage-dependent outer hair cell motility and capacitance. Journal Of Neuroscience 1991, 11: 3096-3110. PMID: 1941076, PMCID: PMC6575435, DOI: 10.1523/jneurosci.11-10-03096.1991.
- Isolated supporting cells from the organ of Corti: Some whole cell electrical characteristics and estimates of gap junctional conductanceSantos-Sacchi J. Isolated supporting cells from the organ of Corti: Some whole cell electrical characteristics and estimates of gap junctional conductance. Hearing Research 1991, 52: 89-98. PMID: 2061216, DOI: 10.1016/0378-5955(91)90190-k.
- Fast Outer Hair Cell Motility: How Fast is Fast?Santos-Sacchi J. Fast Outer Hair Cell Motility: How Fast is Fast? 1990, 87: 69-75. DOI: 10.1007/978-1-4757-4341-8_9.
- Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of CortiSantos-Sacchi J. Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti. Journal Of Neuroscience 1989, 9: 2954-2962. PMID: 2769373, PMCID: PMC6569687, DOI: 10.1523/jneurosci.09-08-02954.1989.
- Whole cell currents and mechanical responses of isolated outer hair cellsSantos-Sacchi J, Dilger J. Whole cell currents and mechanical responses of isolated outer hair cells. Hearing Research 1988, 35: 143-150. PMID: 2461927, DOI: 10.1016/0378-5955(88)90113-x.
- Electrical coupling differs in the in vitro and in vivo organ of CortiSantos-Sacchi J. Electrical coupling differs in the in vitro and in vivo organ of Corti. Hearing Research 1987, 25: 227-232. PMID: 3558131, DOI: 10.1016/0378-5955(87)90094-3.
- Immunocytochemical demonstration of astrocytes in the eighth cranial nerve of the red-eared turtleMarbey D, Santos-Sacchi J. Immunocytochemical demonstration of astrocytes in the eighth cranial nerve of the red-eared turtle. Experimental Neurology 1986, 94: 141-148. PMID: 3530795, DOI: 10.1016/0014-4886(86)90277-3.
- Dye coupling in the organ of CortiSantos-Sacchi J. Dye coupling in the organ of Corti. Cell And Tissue Research 1986, 245: 525-529. PMID: 3757014, PMCID: PMC6042516, DOI: 10.1007/bf00218553.
- The temperature dependence of electrical coupling in the organ of CortiSantos-Sacchi J. The temperature dependence of electrical coupling in the organ of Corti. Hearing Research 1986, 21: 205-211. PMID: 2424883, DOI: 10.1016/0378-5955(86)90219-4.
- The effects of cytoplasmic acidification upon electrical coupling in the organ of CortiSantos-Sacchi J. The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti. Hearing Research 1985, 19: 207-215. PMID: 3934121, DOI: 10.1016/0378-5955(85)90140-6.
- A Ferritin-containing Cell Type in the Stria Vascularis of the Mouse Inner EarSantos-Sacchi J, Marovitz W. A Ferritin-containing Cell Type in the Stria Vascularis of the Mouse Inner Ear. Acta Oto-Laryngologica 1985, 100: 26-32. PMID: 4024891, DOI: 10.3109/00016488509108583.
- A re-evaluation of cell coupling in the organ of CortiSantos-Sacchi J. A re-evaluation of cell coupling in the organ of Corti. Hearing Research 1984, 14: 203-204. PMID: 6746433, DOI: 10.1016/0378-5955(84)90019-4.
- Intercellular communication in the supporting cells of the organ of CortiSantos-Sacchi J, Dallos P. Intercellular communication in the supporting cells of the organ of Corti. Hearing Research 1983, 9: 317-326. PMID: 6841286, DOI: 10.1016/0378-5955(83)90034-5.
- Intracellular Recordings from Cochlear Outer Hair CellsDallos P, Santos-Sacchi J, Flock Å. Intracellular Recordings from Cochlear Outer Hair Cells. Science 1982, 218: 582-584. PMID: 7123260, DOI: 10.1126/science.7123260.
- Determination of cochlear receptor potential characteristics by pseudorandom noiseDallos P, Santos‐Sacchi J, Lutz W. Determination of cochlear receptor potential characteristics by pseudorandom noise. The Journal Of The Acoustical Society Of America 1982, 71: s17-s17. DOI: 10.1121/1.2019254.
- An electronmicroscopic study of microtubules in the development of marginal cells of the mouse stria vascularisSantos-Sacchi J. An electronmicroscopic study of microtubules in the development of marginal cells of the mouse stria vascularis. Hearing Research 1982, 6: 7-13. PMID: 7054137, DOI: 10.1016/0378-5955(82)90003-x.
- Potentiation of the cGMP‐induced Guinea pig acrosome reaction by zincSantos‐Sacchi J, Gordon M, Williams W. Potentiation of the cGMP‐induced Guinea pig acrosome reaction by zinc. Journal Of Experimental Zoology 1980, 213: 289-291. PMID: 6257821, DOI: 10.1002/jez.1402130217.
- Induction of the acrosome reaction in guinea pig spermatozoa by cGMP analogues.Santos-Sacchi J, Gordon M. Induction of the acrosome reaction in guinea pig spermatozoa by cGMP analogues. Journal Of Cell Biology 1980, 85: 798-803. PMID: 6248566, PMCID: PMC2111448, DOI: 10.1083/jcb.85.3.798.
- An Evaluation of Normal Strial Capillary Transport Using the Electron-Opaque Tracers Ferritin and Iron DextranSantos-Sacchi J, Marovitz W. An Evaluation of Normal Strial Capillary Transport Using the Electron-Opaque Tracers Ferritin and Iron Dextran. Acta Oto-Laryngologica 1980, 89: 12-26. PMID: 7405570, DOI: 10.3109/00016488009127103.
- Cytoplasmic microtubules in strial marginal cellsSantos -Sacchi J. Cytoplasmic microtubules in strial marginal cells. European Archives Of Oto-Rhino-Laryngology 1978, 218: 297-300. PMID: 580189, DOI: 10.1007/bf00455566.
- Differential Effects of Primary Fixation with Glutaraldehyde and Osmium Upon the Membranous Systems of the Strial and External Sulcus CellsSantos-Sacchi J. Differential Effects of Primary Fixation with Glutaraldehyde and Osmium Upon the Membranous Systems of the Strial and External Sulcus Cells. Acta Oto-Laryngologica 1978, 86: 56-63. PMID: 99973, DOI: 10.3109/00016487809124720.