Jennifer M. Kwan, MD/PhD
Assistant Professor of Medicine (Cardiovascular Medicine)
Research & Publications
Biography
News
Research Summary
Contributed to the full spectrum of research, from basic science/mechanistic genetic mouse models, translational to epidemiological analyses of large datasets such as the SRTR (transplant registry) featuring 200k+ pts to evaluate risk factors associated with adverse transplant outcomes in obese patients and the UCSF dataset w/several million patients to evaluate for cardio-oncology adverse outcomes risk factors.
Extensive Research Description
I conducted molecular biology research at UC Berkeley to elucidate genetic regulatory elements in innate immune response and gluconeogenesis/lipogenesis in HIV patients on omega 3 supplements --> MSTP (MD/PhD) training with PhD in biochemistry and molecular genetics using animal models to elucidate role of insulin pathway in adipogenesis and tumorigenesis --> T32 training with IRB approved human translational studies coupled with epidemiological training/studies to try to understand why obesity increases risk of adverse renal transplant/cardio renal outcomes. I harvested human adipose tissue from lean and obese individuals, isolated exosomes/miRNA and lymphocytes via flow cytometry and performed RNA seq transcriptomic analyses to identify differentially expressed and functional pathways. Currently interested/working on translational and big data research in cardio-oncology, to better understand those at risk for adverse cardiovascular effects with goal of improving cardiovascular outcomes of cancer patients, particularly patients on new tyrosine kinase inhibitors and immunotherapy such as checkpoint inhibitors.
Coauthors
Research Interests
Arrhythmias, Cardiac; Medical Oncology; Cardiomyopathies
Selected Publications
- Abstract 13769: AT1R Autoantibody Levels Are Elevated in Patients Who Required Immunosuppression Escalation in Immune Checkpoint Inhibitor Mediated MyocarditisAkhlaghi N, Shen M, Bow L, Miller M, Hwa J, Halene S, Baldassarre L, Kwan J. Abstract 13769: AT1R Autoantibody Levels Are Elevated in Patients Who Required Immunosuppression Escalation in Immune Checkpoint Inhibitor Mediated Myocarditis Circulation 2022, 146: a13769-a13769. DOI: 10.1161/circ.146.suppl_1.13769.
- Short-Term Outcomes After Myopericarditis Related to COVID-19 VaccinationPareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O’Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.
- Short-Term Outcomes After Myopericarditis Related to COVID-19 VaccinationPareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O'Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMID: 36357140, PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.
- Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.
- Characteristics, barriers, and career intentions of a national cohort of LGBTQ+ MD/PhD and DO/PhD trainees.Marr MC, Heffron AS, Kwan JM. Characteristics, barriers, and career intentions of a national cohort of LGBTQ+ MD/PhD and DO/PhD trainees. BMC Medical Education 2022, 22: 304. PMID: 35449040, PMCID: PMC9027045, DOI: 10.1186/s12909-022-03378-8.
- Multimodality Advanced Cardiovascular and Molecular Imaging for Early Detection and Monitoring of Cancer Therapy-Associated Cardiotoxicity and the Role of Artificial Intelligence and Big DataKwan JM, Oikonomou EK, Henry ML, Sinusas AJ. Multimodality Advanced Cardiovascular and Molecular Imaging for Early Detection and Monitoring of Cancer Therapy-Associated Cardiotoxicity and the Role of Artificial Intelligence and Big Data Frontiers In Cardiovascular Medicine 2022, 9: 829553. PMID: 35369354, PMCID: PMC8964995, DOI: 10.3389/fcvm.2022.829553.
- MYOCARDIAL IMPACT OF CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL (CHIP) SECRETOMES IN CARDIO-ONCOLOGY PATIENTSKwan J, Vanoudenhove J, Vanoudenhove J, Halder S, Halder S, Biancon G, Jain K, Jain K, Chakraborty R, Lustberg M, Lustberg M, Pusztai L, Campbell S, Campbell S, Zhao H, Halene S, Hwa J. MYOCARDIAL IMPACT OF CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL (CHIP) SECRETOMES IN CARDIO-ONCOLOGY PATIENTS Journal Of The American College Of Cardiology 2022, 79: 1912. DOI: 10.1016/s0735-1097(22)02903-5.
- ADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH KINASE INHIBITORS IN THE TREATMENT OF CANCER REVEAL SPECIFIC RISK BASED ON THE KINASE INHIBITOR - A SINGLE-CENTER RETROSPECTIVE COHORT STUDYKwan J, Shen M, Mankbadi M, Wang P, Zaman S, Lee S, Jiang M, Tao W, Wei W, Akhlaghi N. ADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH KINASE INHIBITORS IN THE TREATMENT OF CANCER REVEAL SPECIFIC RISK BASED ON THE KINASE INHIBITOR - A SINGLE-CENTER RETROSPECTIVE COHORT STUDY Journal Of The American College Of Cardiology 2022, 79: 1924. DOI: 10.1016/s0735-1097(22)02915-1.
- ADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH IMMUNE CHECKPOINT INHIBITORS - A SINGLE CENTER RETROSPECTIVE COHORT STUDYKwan J, Akhlaghi N, Jiang M, Shen M, Im Y, Mankbadi M, Wang P, Zaman S, Lee S, Tao W, Wei W, Ma S. ADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH IMMUNE CHECKPOINT INHIBITORS - A SINGLE CENTER RETROSPECTIVE COHORT STUDY Journal Of The American College Of Cardiology 2022, 79: 1909. DOI: 10.1016/s0735-1097(22)02900-x.
- Gender disparities among medical students choosing to pursue careers in medical research: a secondary cross-sectional cohort analysisSnyder A, Xiang D, Smith A, Esswein S, Toubat O, Di Capua J, Kwan JM, Daye D. Gender disparities among medical students choosing to pursue careers in medical research: a secondary cross-sectional cohort analysis BMC Medical Education 2021, 21: 591. PMID: 34823508, PMCID: PMC8620216, DOI: 10.1186/s12909-021-03004-z.
- Adverse cardiovascular events in patients treated with mogamulizumabKwan J, Henry M, Cook K, Higgins A, Cuomo J, Foss F, Baldassarre L. Adverse cardiovascular events in patients treated with mogamulizumab American Heart Journal Plus Cardiology Research And Practice 2021, 9: 100049. DOI: 10.1016/j.ahjo.2021.100049.
- The Role and Impact of Social Media in Cardio-oncology During the COVID-19 PandemicKwan JM, Henry ML, Christophers B, Tamirisa K, Thamman R, Sadler D, Aggarwal NR, Cheng R, Parwani P, Dent S, Ismail-Khan R, Fradley MG, Brown SA. The Role and Impact of Social Media in Cardio-oncology During the COVID-19 Pandemic Current Oncology Reports 2021, 23: 99. PMID: 34259950, PMCID: PMC8278372, DOI: 10.1007/s11912-021-01081-3.
- A new classification of cardio-oncology syndromes.de Boer RA, Aboumsallem JP, Bracun V, Leedy D, Cheng R, Patel S, Rayan D, Zaharova S, Rymer J, Kwan JM, Levenson J, Ronco C, Thavendiranathan P, Brown SA. A new classification of cardio-oncology syndromes. Cardio-oncology (London, England) 2021, 7: 24. PMID: 34154667, PMCID: PMC8218489, DOI: 10.1186/s40959-021-00110-1.
- Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell LymphomaKwan JM, Odanovic N, Arbune A, Higgins A, Henry M, Greif D, Foss F, Baldassarre LA. Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma JACC Case Reports 2021, 3: 1018-1023. PMID: 34317676, PMCID: PMC8311348, DOI: 10.1016/j.jaccas.2021.04.001.
- CARDIOVASCULAR AND MORTALITY OUTCOMES IN ONCOLOGY PATIENTS HOSPITALIZED WITH COVID-19Kwan J, Lee S, Tao W, Wei W, Simonov M, Halene S, Hwa J, Baldassarre L. CARDIOVASCULAR AND MORTALITY OUTCOMES IN ONCOLOGY PATIENTS HOSPITALIZED WITH COVID-19 Journal Of The American College Of Cardiology 2021, 77: 3294. PMCID: PMC8091382, DOI: 10.1016/s0735-1097(21)04648-9.
- CARDIOVASCULAR AND MORTALITY OUTCOMES OF HOSPITALIZED COVID-19 PATIENTS STRATIFIED BY RACE AND ETHNICITYKwan J, Lee S, Tao W, Wei W, Simonov M, Halene S, Hwa J, Spatz E. CARDIOVASCULAR AND MORTALITY OUTCOMES OF HOSPITALIZED COVID-19 PATIENTS STRATIFIED BY RACE AND ETHNICITY Journal Of The American College Of Cardiology 2021, 77: 3050. PMCID: PMC8091439, DOI: 10.1016/s0735-1097(21)04405-3.
- 57884 Fast strain-encoded cardiac magnetic resonance detects immune checkpoint inhibitor associated cardiotoxicityCuomo J, Cuomo J, Ragheb E, Ragheb E, Feher A, Kwan J, Huber S, Mojibian H, Peters D, Sinusas A, Baldassarre L. 57884 Fast strain-encoded cardiac magnetic resonance detects immune checkpoint inhibitor associated cardiotoxicity Journal Of Clinical And Translational Science 2021, 5: 141-142. PMCID: PMC8827987, DOI: 10.1017/cts.2021.761.
- A neutrophil activation signature predicts critical illness and mortality in COVID-19Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19 Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.
- Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicityHiggins AY, Arbune A, Soufer A, Ragheb E, Kwan JM, Lamy J, Henry M, Cuomo JR, Charifa A, Gallegos C, Hull S, Coviello JS, Bader AS, Peters DC, Huber S, Mojibian HR, Sinusas AJ, Kluger H, Baldassarre LA. Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity PLOS ONE 2021, 16: e0246764. PMID: 33606757, PMCID: PMC7895343, DOI: 10.1371/journal.pone.0246764.
- Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammationGu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.
- Factors associated with underrepresented minority physician scientist trainee career choicesSiebert AL, Chou S, Toubat O, Adami AJ, Kim H, Daye D, Kwan JM. Factors associated with underrepresented minority physician scientist trainee career choices BMC Medical Education 2020, 20: 422. PMID: 33176758, PMCID: PMC7656762, DOI: 10.1186/s12909-020-02328-6.
- Circulating markers of angiogenesis and endotheliopathy in COVID‐19Pine AB, Meizlish ML, Goshua G, Chang C, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, Dijk D, Hwa J, Lee AI, Chun HJ. Circulating markers of angiogenesis and endotheliopathy in COVID‐19 Pulmonary Circulation 2020, 10: 1-4. PMID: 33282193, PMCID: PMC7691906, DOI: 10.1177/2045894020966547.
- A neutrophil activation signature predicts critical illness and mortality in COVID-19.Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun H. A neutrophil activation signature predicts critical illness and mortality in COVID-19. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32908988, PMCID: PMC7480036, DOI: 10.1101/2020.09.01.20183897.
- Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19.Meizlish ML, Pine AB, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan J, Price C, Dela Cruz C, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32637968, PMCID: PMC7340194, DOI: 10.1101/2020.06.29.20140376.
- A nationwide assessment of perceptions of research-intense academic careers among predoctoral MD and MD-PhD traineesKwan JM, Toubat O, Harrison AM, Riddle M, Wu B, Kim H, Basta DW, Adami AJ, Daye D. A nationwide assessment of perceptions of research-intense academic careers among predoctoral MD and MD-PhD trainees Journal Of Clinical And Translational Science 2020, 4: 307-316. PMID: 33244411, PMCID: PMC7681110, DOI: 10.1017/cts.2020.18.
- A NATIONWIDE ASSESSMENT OF FACTORS INFLUENCING RESEARCH AND ACADEMIC CAREERS AMONG MD AND MD-PHD TRAINEES INTERESTED IN CARDIOLOGYKwan J, Toubat O, Kim H, Daye D. A NATIONWIDE ASSESSMENT OF FACTORS INFLUENCING RESEARCH AND ACADEMIC CAREERS AMONG MD AND MD-PHD TRAINEES INTERESTED IN CARDIOLOGY Journal Of The American College Of Cardiology 2020, 75: 3512. DOI: 10.1016/s0735-1097(20)34139-5.
- Hepatotoxicity and Recurrent NSTEMI While on Pembrolizumab for Metastatic Giant Cell Bone Tumor.Kwan JM, Cheng R, Feldman LE. Hepatotoxicity and Recurrent NSTEMI While on Pembrolizumab for Metastatic Giant Cell Bone Tumor. The American Journal Of The Medical Sciences 2019, 357: 343-347. PMID: 30638772, DOI: 10.1016/j.amjms.2018.11.017.
- CARDIAC MAGNETIC RESONANCE IMAGING FEATURE TRACKING STRAIN AS A SENSITIVE MARKER OF CARDIOTOXICITY IN BREAST CANCER PATIENTS COMPARED WITH LEFT VENTRICULAR EJECTION FRACTIONKwan J, Arbune A, Henry M, Dupee D, Soufer A, Baldassarre L. CARDIAC MAGNETIC RESONANCE IMAGING FEATURE TRACKING STRAIN AS A SENSITIVE MARKER OF CARDIOTOXICITY IN BREAST CANCER PATIENTS COMPARED WITH LEFT VENTRICULAR EJECTION FRACTION Journal Of The American College Of Cardiology 2019, 73: 1666. DOI: 10.1016/s0735-1097(19)32272-7.
- Donor and Recipient Ethnicity Impacts Renal Graft Adverse Outcomes.Kwan JM, Hajjiri Z, Chen YF, Metwally A, Perkins DL, Finn PW. Donor and Recipient Ethnicity Impacts Renal Graft Adverse Outcomes. Journal Of Racial And Ethnic Health Disparities 2018, 5: 1003-1013. PMID: 29270842, DOI: 10.1007/s40615-017-0447-9.
- Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careersKwan JM, Daye D, Schmidt ML, Conlon CM, Kim H, Gaonkar B, Payne AS, Riddle M, Madera S, Adami AJ, Winter KQ. Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers BMC Medical Education 2017, 17: 115. PMID: 28697782, PMCID: PMC5505137, DOI: 10.1186/s12909-017-0954-8.
- Effect of the Obesity Epidemic on Kidney Transplantation: Obesity Is Independent of Diabetes as a Risk Factor for Adverse Renal Transplant Outcomes.Kwan JM, Hajjiri Z, Metwally A, Finn PW, Perkins DL. Effect of the Obesity Epidemic on Kidney Transplantation: Obesity Is Independent of Diabetes as a Risk Factor for Adverse Renal Transplant Outcomes. PloS One 2016, 11: e0165712. PMID: 27851743, PMCID: PMC5112887, DOI: 10.1371/journal.pone.0165712.
- T cells and lung injury. Impact of rapamycin.Nakajima T, Lin KW, Li J, McGee HS, Kwan JM, Perkins DL, Finn PW. T cells and lung injury. Impact of rapamycin. American Journal Of Respiratory Cell And Molecular Biology 2014, 51: 294-9. PMID: 24641710, PMCID: PMC4148036, DOI: 10.1165/rcmb.2013-0171OC.
- Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis.Nogueira V, Sundararajan D, Kwan JM, Peng XD, Sarvepalli N, Sonenberg N, Hay N. Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. The EMBO Journal 2012, 31: 1134-46. PMID: 22307088, PMCID: PMC3297989, DOI: 10.1038/emboj.2011.478.
- The Anticancer Activity of the N-Terminal CARD-Like Domain of Arginine Deiminase (ADI) from Pseudomonas aeruginosaKundu M, Thomas J, Fialho A, Kwan J, Moreira L, Mahfouz M, Das Gupta T, Chakrabarty A. The Anticancer Activity of the N-Terminal CARD-Like Domain of Arginine Deiminase (ADI) from Pseudomonas aeruginosa Letters In Drug Design & Discovery 2009, 6: 403-412. DOI: 10.2174/157018009789057580.
- Bacterial proteins as potential drugs in the treatment of leukemiaKwan JM, Fialho AM, Kundu M, Thomas J, Hong CS, Gupta T, Chakrabarty AM. Bacterial proteins as potential drugs in the treatment of leukemia Leukemia Research 2009, 33: 1392-1399. PMID: 19250673, DOI: 10.1016/j.leukres.2009.01.024.
- Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition.Choi SH, Byun HM, Kwan JM, Issa JP, Yang AS. Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition. British Journal Of Haematology 2007, 138: 616-23. PMID: 17686055, DOI: 10.1111/j.1365-2141.2007.06707.x.
- Rapid and quantitative method of allele-specific DNA methylation analysis.Wong HL, Byun HM, Kwan JM, Campan M, Ingles SA, Laird PW, Yang AS. Rapid and quantitative method of allele-specific DNA methylation analysis. BioTechniques 2006, 41: 734-9. PMID: 17191619, DOI: 10.2144/000112305.
- Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.Chuang JC, Yoo CB, Kwan JM, Li TW, Liang G, Yang AS, Jones PA. Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine. Molecular Cancer Therapeutics 2005, 4: 1515-20. PMID: 16227400, DOI: 10.1158/1535-7163.MCT-05-0172.
- Immunity regulatory DNAs share common organizational features in Drosophila.Senger K, Armstrong GW, Rowell WJ, Kwan JM, Markstein M, Levine M. Immunity regulatory DNAs share common organizational features in Drosophila. Molecular Cell 2004, 13: 19-32. PMID: 14731391.