Dongju Seo, PhD
Research & Publications
Biography
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Research Summary
My research is focused on understanding neural mechanisms underlying the link between stress and addiction and developing effective treatment strategies for stress and addiction related illnesses. I use multimodal neuroimaging combining functional magnetic resonance imaging (fMRI), electrocardiogram (ECG), and hormone monitoring to examine neurobiological correlates of stress, autonomic nervous system, and hypothalamic-pituitary-adrenal axis regulation and their roles in addiction. I am interested in developing an interdisciplinary program of translational research to identify common and differential neural circuits involved in various types of addictive disorders (e.g, alcoholism and other substance abuse) with the application of advanced multimodal neuroimaging techniques.
Extensive Research Description
Laboratory for Healthy Minds (LHM)
https://medicine.yale.edu/lab/lhm/
The LHM (director: Dongju Seo, PhD) is a clinical neuroimaging laboratory for translational research of stress and addiction. Its mission is to understand the neurobiological mechanisms of and develop effective treatment for stress and addiction related disorders. To bridge the gap between neuroscience and clinical research, LHM conducts interdisciplinary research using novel approaches such as simultaneous collection of fMRI and peripheral measures including the autonomic nervous system (electrocardiogram (ECG)) and hypothalamic-pituitary-adrenal (HPA) axis. LHM has two sections of laboratory facilities located at large research centers: (1) clinical research section located at Yale Stress Center and (2) neuroimaging section located at Yale Magnetic Resonance Research Center. In addition to multimodal imaging, LHM utilizes intensive longitudinal methods including daily monitoring via smartphone technology to collect daily stress and addiction-related behaviors in a real-life setting.
Ongoing studies at LHM focus on the following four areas.
1) Brain & Heart
"Multimodal neuroimaging of stress, arousal, and alcoholism risk"
The goal of this project is to identify and develop neural makers of alcoholism risk and associated stress and autonomic nervous system dysregulation to predict future alcohol intake in heavy social drinkers. This project involves a multimodal neuroimaging technique combining functional magnetic resonance imaging (fMRI) and electrocardiogram (ECG).
2) Brain & Hormone
"Dynamic neurobiological responses in alcoholism and early adversity"
This project examines neurobiological mechanisms of comorbid alcoholism and early adversity and their prospective prediction of alcohol relapse using multimodal neuroimaging that combines fMRI and HPA axis measures. The study utilizes a novel task involving exposure to stress, alcohol, and neutral cues in separate blocks, which allows simultaneous fMRI and stress hormone monitoring. After the MRI scan, participants are engaged in 8-week outpatient treatment and then prospectively followed for 90 days. We utilizes face-to-face follow-up interviews in conjunction with daily monitoring of stress and alcohol use through a smartphone app.
3) Stress, Mood, and Addiction
This study aims to understand the neurobiology of comorbidity between depression and alcohol misuse using fMRI and HPA axis measures. The project examines brain and hormone responses to stress and alcohol cues and functional connectivity patterns that may contribute to mood and reward dysregulation in individuals with comorbid depression and alcohol misuse.
4) Technology-Assisted Prevention
The LHM develops a technology-assisted prevention program for stress and addiction related illnesses (e.g., alcohol misuse) using a smartphone app. This project aims to develop an innovative prevention program involving computer and smartphone-app based intervention. Using the technology-assisted prevention program, the project is intended to reach out young adults and those who reside in various community settings to prevent addiction.
Coauthors
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Selected Publications
- 1994-P: Task-Oriented Connectivity Analysis of Disease-Dependent Effects of DietWATT C, STANLEY T, LACADIE C, LAM K, SAVOYE M, SINHA R, CONSTABLE T, SEO D, HWANG J, BELFORT-DEAGUIAR R. 1994-P: Task-Oriented Connectivity Analysis of Disease-Dependent Effects of Diet. Diabetes 2020, 69 DOI: 10.2337/db20-1994-p.
- 145-OR: GLP-1 Analogue Effects on Neural Responses to High-Fructose Corn Syrup and Eating Behavior in ObesityJOSEPH K, LEVENTHAL J, HWANG S, KNIGHT M, SEO D, LACADIE C, VAN NAME M, CAPRIO S, SHERR J, TAMBORLANE W, SINHA R, JASTREBOFF A. 145-OR: GLP-1 Analogue Effects on Neural Responses to High-Fructose Corn Syrup and Eating Behavior in Obesity. Diabetes 2020, 69 DOI: 10.2337/db20-145-or.
- Differential resting state connectivity responses to glycemic state in type 1 diabetesParikh L, Seo D, Lacadie C, Belfort-DeAguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang J. Differential resting state connectivity responses to glycemic state in type 1 diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019 DOI: 10.1210/jcem/dgz004.
- 275-LB: Connectome Predictive Modeling May Identify Brain Connectivity Signatures to Help Predict Who Will Benefit from Low-Calorie DietGROSKREUTZ D, LAM W, LACADIE C, ELSHAFIE A, HWANG J, SEO D, SAVOYE M, SINHA R, CONSTABLE T, SHERWIN R, BELFORT-DEAGUIAR R. 275-LB: Connectome Predictive Modeling May Identify Brain Connectivity Signatures to Help Predict Who Will Benefit from Low-Calorie Diet. Diabetes 2019, 68 DOI: 10.2337/db19-275-lb.
- Short-Term Weight Loss Undermines Brain Regulation of Food ConsumptionLAM W, SEO D, LACADIE C, SCHMIDT C, ROSENBERG S, HOANG H, HWANG J, CONSTABLE T, SAVOYE M, SINHA R, SHERWIN R, BELFORT-DEAGUIAR R. Short-Term Weight Loss Undermines Brain Regulation of Food Consumption. Diabetes 2018, 67 DOI: 10.2337/db18-1802-p.
- Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network ConnectivityGROSKREUTZ D, HWANG J, SEO D, LACADIE C, PARIKH L, BELFORT-DEAGUIAR R, SCHEINOST D, SINHA R, CONSTABLE T, SHERWIN R. Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity. Diabetes 2018, 67 DOI: 10.2337/db18-11-lb.
- Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in ObesityGROSKREUTZ D, SINHA R, LACADIE C, LAM W, HAMZA M, SCHMIDT C, SEO D, HWANG J, BELFORT-DEAGUIAR R, LEVENTHAL J, ROSENBERG S, PARIKH L, CONSTABLE T, SHERWIN R, JASTREBOFF A. Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity. Diabetes 2018, 67 DOI: 10.2337/db18-365-or.
- 98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use DisordersSinha R, Seo D, Lacadie C, Constable T, Hermes G. 98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use Disorders. Biological Psychiatry 2018, 83: s40. DOI: 10.1016/j.biopsych.2018.02.116.
- Binge-heavy alcohol alters cortisol and subjective craving: Impact on compulsive alcohol motivation and intakeBlaine S, Seo D, Sinha R. Binge-heavy alcohol alters cortisol and subjective craving: Impact on compulsive alcohol motivation and intake. Alcohol 2017, 60: 212-213. DOI: 10.1016/j.alcohol.2017.02.224.
- PM304. Neural Circuits for Stress-related Impulse Control Difficulties in AlcoholismSeo D, Lacadie C, Sinha R. PM304. Neural Circuits for Stress-related Impulse Control Difficulties in Alcoholism. The International Journal Of Neuropsychopharmacology 2016, 19: 8-9. PMCID: PMC5616240, DOI: 10.1093/ijnp/pyw041.304.
- Neuroplasticity and Predictors of Alcohol Recovery.Seo D, Sinha R. Neuroplasticity and Predictors of Alcohol Recovery. Alcohol Research 2015, 37: 143-52. PMID: 26259094, PMCID: PMC4476600.
- Chapter 3 Prefrontal Limbic-Striatal Circuits and Alcohol Addiction in HumansSeo D, Sinha R. Chapter 3 Prefrontal Limbic-Striatal Circuits and Alcohol Addiction in Humans. 2014, 49-63. DOI: 10.1016/b978-0-12-405941-2.00003-1.
- Neural correlates of preparatory and regulatory control over positive and negative emotionSeo D, Olman CA, Haut KM, Sinha R, MacDonald AW, Patrick CJ. Neural correlates of preparatory and regulatory control over positive and negative emotion. Social Cognitive And Affective Neuroscience 2013, 9: 494-504. PMID: 23887812, PMCID: PMC3989138, DOI: 10.1093/scan/nst115.
- Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse RiskSeo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.
- Neural Mechanisms of Stress and AddictionSeo D, Sinha R. Neural Mechanisms of Stress and Addiction. 2011, 209-233. DOI: 10.1002/9781119998938.ch9.
- Circulating glucose levels modulate neural control of desire for high-calorie foods in humansPage KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.
- Sex differences in neural responses to stress and alcohol context cuesSeo D, Jia Z, Lacadie CM, Tsou KA, Bergquist K, Sinha R. Sex differences in neural responses to stress and alcohol context cues. Human Brain Mapping 2010, 32: 1998-2013. PMID: 21162046, PMCID: PMC3236497, DOI: 10.1002/hbm.21165.
- Decreased Activity in Brain Regions of Emotion Regulation Predicted Alcohol Cravings during Stress and Alcohol-cue Exposures in Individuals with Alcohol DependenceSeo D, Lacadie C, Bergquist K, Sinha R. Decreased Activity in Brain Regions of Emotion Regulation Predicted Alcohol Cravings during Stress and Alcohol-cue Exposures in Individuals with Alcohol Dependence. NeuroImage 2009, 47: s138. DOI: 10.1016/s1053-8119(09)71362-x.
- Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disordersSeo D, Patrick CJ, Kennealy PJ. Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders. Aggression And Violent Behavior 2008, 13: 383-395. PMID: 19802333, PMCID: PMC2612120, DOI: 10.1016/j.avb.2008.06.003.
Clinical Trials
Conditions | Study Title |
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Addictive Behaviors; Mental Health & Behavioral Research | Effects of Stress Intervention |
Alcohol Addiction | Neurobiological Responses in Alcoholism and Early Trauma |