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Dianqing (Dan) Wu, PhD

Gladys Phillips Crofoot Professor of Pharmacology

Research & Publications
Biography
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Research Summary

Dr. Wu’s lab is interested in the mechanisms and functions of chemoattractant and Wnt-activated signaling. Chemoattractants, including chemokines, play an important role in host defense. However, their unchecked activities contribute to may inflammation-related diseases, including atherosclerosis, arthritis, tumorigenesis, and various allergies. The Wnt family of secretory glycoproteins participates in a wide variety of developmental events including, control of cell growth, generation of cell polarity, and specification of cell fate. Wnt pathways have been also closely linked to tumorigenesis, glucose metabolism, and bone formation. We are using a combination of molecular and cell biological, biochemical, chemical biological, transgenic, functional genomic, and proteomic approaches to discover novel signaling mechanisms and functions for these signaling proteins.

Specialized Terms: Wnt; signal transduction; G protein, Chemotaxis;Cell migration; Cancer biology and therapeutics; Stem cell biology; Chemoattractant signaling; Inflammation

Extensive Research Description

Our long-term goal is to understand the molecular basis and function of signal transduction pathways, with the emphasis on those initiated by seven-transmembrane receptors. These receptors can be divided into two groups: one couples to heterotrimeric GTP-binding proteins; and the other binds to ligands including hedgehog proteins and Wnt proteins. Currently, we are focusing on chemoattractant and Wnt-activated signaling. Chemoattractants, including the superfamily of chemotactic cytokines, chemokines, play an important role in host defense by attracting and activating leukocytes at sites of injury and infection. However, their unchecked activities contribute to may inflammation-related diseases, including atherosclerosis, arthritis, tumorigenesis, and various allergies. Work in my lab has made significant contributions to the understanding of signaling mechanisms and functions of a number of chemoattractant-activated pathways. These include pathways linked by PLC ß, PI3K?, PIXa/Pak/Cdc42, PTEN, P-Rex1, and Myo1f. We are continuing to use a combination of molecular and cell biological, biochemical, transgenic, functional genomic, and proteomic approaches to characterize novel chemoattractant signaling mechanisms and study their functions in cell migration and inflammation-related paradigms. The Wnt family of secretory glycoproteins participates in a wide variety of developmental events including, control of cell growth, generation of cell polarity, and specification of cell fate. Wnt pathways have been also closely linked to tumorigenesis and bone formation. Most notable contributions from my is the discovery of the interaction between Wnt coreceptor LRP-5 and Axin, which provides the first connection from a Wnt receptor to a intracellular signaling component and the characterization of the role of Dkk2 in regulation of osteogenic differentiation. We are continuing to work on the elucidation of fundamental mechanisms of Wnt signaling and characterization of their role in pathophysiological processes, including osteoporosis, metabolic syndrome, diabetes, and tumorigenesis, using computation-based virtual screening and chemical genomic approaches, in addition to the aforementioned ones.1) Wnt signaling mechanisms and functions
2) Regulation of neutrophil migration
3) Atherosclerosis
4) Wnt signaling in bone development and diseases
5) Wnt signaling and stem cell biology

Coauthors

Research Interests

Chemotaxis; Inflammation; Pharmacology; Stem Cells; Signal Transduction; GTP-Binding Proteins; Chemicals and Drugs

Research Images

4436962

A polarized mouse neutrophil

Selected Publications

Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activationHan S, Wang Q, Song Y, Pang M, Ren C, Wang J, Guan D, Xu W, Li F, Wang F, Zhou X, Fernández-Hernando C, Zhang H, Wu D, Ye Z. Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation IScience 2023, 26: 106613. PMID: 37128603, PMCID: PMC10148154, DOI: 10.1016/j.isci.2023.106613.
Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Vesely M, Kim W, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM, Bothwell ALM. Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1 IScience 2021, 24: 102411. PMID: 33997693, PMCID: PMC8099562, DOI: 10.1016/j.isci.2021.102411.
In vivo self-assembled small RNAs as a new generation of RNAi therapeuticsFu Z, Zhang X, Zhou X, Ur-Rehman U, Yu M, Liang H, Guo H, Guo X, Kong Y, Su Y, Ye Y, Hu X, Cheng W, Wu J, Wang Y, Gu Y, Lu S, Wu D, Zen K, Li J, Yan C, Zhang C, Chen X. In vivo self-assembled small RNAs as a new generation of RNAi therapeutics Cell Research 2021, 31: 631-648. PMID: 33782530, PMCID: PMC8169669, DOI: 10.1038/s41422-021-00491-z.
Srf Is Required For Neutrophil Migration In Response To InflammationTaylor A, Tang W, Bruscia E, Zhang P, Lin A, Gaines P, Vu L, Wu D, Halene S. Srf Is Required For Neutrophil Migration In Response To Inflammation Blood 2013, 122: 319-319. DOI: 10.1182/blood.v122.21.319.319.
PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis miceLi H, Park D, Abdul-Muneer P, Xu B, Wang H, Xing B, Wu D, Li S. PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice Neuroscience 2013, 253: 89-99. PMID: 24012746, PMCID: PMC9529370, DOI: 10.1016/j.neuroscience.2013.08.051.
Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.Kang H, Viollet B, Wu D. Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice. Journal Of Biological Chemistry 2013, 288: 23432. PMCID: PMC3743511, DOI: 10.1074/jbc.a112.430389.
P‐Rex1 is critical for vascular hyper‐permeability and edema in the lungsNaikawadi R, Cheng N, Vogel S, Wu D, Malik A, Ye R. P‐Rex1 is critical for vascular hyper‐permeability and edema in the lungs The FASEB Journal 2012, 26: 842.10-842.10. DOI: 10.1096/fasebj.26.1_supplement.842.10.
A non‐GPCR dependent role for P‐Rex1 in endothelial cellsNaikawadi R, Cheng N, Wu D, Ye R. A non‐GPCR dependent role for P‐Rex1 in endothelial cells The FASEB Journal 2011, 25: 631.9-631.9. DOI: 10.1096/fasebj.25.1_supplement.631.9.
[High glucose increases periostin expression and the related signal pathway in adult rat cardiac fibroblasts].Zou P, Wu L, Wu D, Fan D, Cui X, Zhou Y, Wang C, Li L. [High glucose increases periostin expression and the related signal pathway in adult rat cardiac fibroblasts]. Acta Physiol Sinica 2010, 62: 247-54. PMID: 20571742.
P‐Rex1 regulates lung microvascular permeabilityNaikawadi R, Cheng N, Wu D, Ye R. P‐Rex1 regulates lung microvascular permeability The FASEB Journal 2010, 24: lb554-lb554. DOI: 10.1096/fasebj.24.1_supplement.lb554.
Sites of Regulated Phosphorylation that Control K-Cl Cotransporter ActivityRinehart J, Maksimova Y, Tanis J, Stone K, Hodson C, Zhang J, Risinger M, Pan W, Wu D, Colangelo C. Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity Journal Of End-to-End-testing 2009, 138: 525-536. DOI: 10.1016/s9999-9994(09)20390-4.
Sites of Regulated Phosphorylation that Control K-Cl Cotransporter ActivityRinehart J, Maksimova Y, Tanis J, Stone K, Hodson C, Zhang J, Risinger M, Pan W, Wu D, Colangelo C, Forbush B, Joiner C, Gulcicek E, Gallagher P, Lifton R. Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity Journal Of End-to-End-testing 2009, 138: 525-536. DOI: 10.1016/s9999-9994(09)20441-7.
Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction*Tang L, Deng N, Wang L, Dai J, Wang Z, Jiang X, Li S, Li L, Sheng Q, Wu D, Li L, Zeng R. Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction* Molecular & Cellular Proteomics 2007, 6: 1952-1967. PMID: 17693683, DOI: 10.1074/mcp.m700120-mcp200.
Metabolic Syndrome—What We Know and What We Don't Know LPR6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors. Science 315: 1278–1282, 2007Mani A, Radhakrishnan J, Wang H, Mani A, Mani M, Nelson-Williams C, Carew K, Mane S, Najmabadi H, Wu D, Lifton R. Metabolic Syndrome—What We Know and What We Don't Know LPR6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors. Science 315: 1278–1282, 2007 Journal Of The American Society Of Nephrology 2007, 18: 1619-1623. DOI: 10.1681/asn.2007040522.
Corrigendum to “Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells” [Prostag. Oth. Lipid. M. 76 (2005) 95–104]Li Z, Paik J, Wang Z, Hla T, Wu D. Corrigendum to “Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells” [Prostag. Oth. Lipid. M. 76 (2005) 95–104] Prostaglandins And Other Lipid Mediators 2006, 79: 195. DOI: 10.1016/j.prostaglandins.2005.10.003.
Using biosensors to detect the release of serotonin from taste buds during taste stimulation.Huang Y, Maruyama Y, Lu K, Pereira E, Plonsky I, Baur J, Wu D, Roper S. Using biosensors to detect the release of serotonin from taste buds during taste stimulation. Archives Italiennes De Biologie 2005, 143: 87-96. PMID: 16106989, PMCID: PMC3712826.
Mouse Taste Buds Use Serotonin as a NeurotransmitterHuang Y, Maruyama Y, Lu K, Pereira E, Plonsky I, Baur J, Wu D, Roper S. Mouse Taste Buds Use Serotonin as a Neurotransmitter Journal Of Neuroscience 2005, 25: 843-847. PMID: 15673664, PMCID: PMC6725637, DOI: 10.1523/jneurosci.4446-04.2005.
PLCβ Is Critical for T-Cell Chemotaxis In Vivo.Bach T, Chen Q, Jordan M, Choi J, Wu D, Koretzky G, Zigmond S, Abrams C. PLCβ Is Critical for T-Cell Chemotaxis In Vivo. Blood 2004, 104: 2650-2650. DOI: 10.1182/blood.v104.11.2650.2650.
Roles of PI3K in Neutrophil FunctionHannigan M, Huang C, Wu D. Roles of PI3K in Neutrophil Function 2004, 282: 165-175. PMID: 14594217, DOI: 10.1007/978-3-642-18805-3_6.
Analysis of the Coupling of G12/13 to G Protein-Coupled Receptors Using a Luciferase Reporter AssayLiu B, Wu D. Analysis of the Coupling of G12/13 to G Protein-Coupled Receptors Using a Luciferase Reporter Assay 2003, 237: 145-149. DOI: 10.1385/1-59259-430-1:145.
Analysis of G Protein-Mediated Activation of Phospholipase C in Cultured CellsLiu B, Wu D. Analysis of G Protein-Mediated Activation of Phospholipase C in Cultured Cells 2003, 237: 99-102. DOI: 10.1385/1-59259-430-1:99.
Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1*Mao J, Maye P, Kogerman P, Tejedor F, Toftgard R, Xie W, Wu G, Wu D. Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1* Journal Of Biological Chemistry 2002, 277: 35156-35161. PMID: 12138125, DOI: 10.1074/jbc.m206743200.
Gα16 Couples Chemoattractant Receptors to NF-κB ActivationYang M, Sang H, Rahman A, Wu D, Malik A, Ye R. Gα16 Couples Chemoattractant Receptors to NF-κB Activation The Journal Of Immunology 2001, 166: 6885-6892. PMID: 11359849, DOI: 10.4049/jimmunol.166.11.6885.
Deficient long‐term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C β4 mutant miceMiyata M, Kim H, Hashimoto K, Lee T, Cho S, Jiang H, Wu Y, Jun K, Wu D, Kano M, Shin H. Deficient long‐term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C β4 mutant mice European Journal Of Neuroscience 2001, 13: 1945-1954. PMID: 11403688, DOI: 10.1046/j.0953-816x.2001.01570.x.
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling PathwayMao J, Wang J, Liu B, Pan W, Farr G, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D. Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway Molecular Cell 2001, 7: 801-809. PMID: 11336703, DOI: 10.1016/s1097-2765(01)00224-6.
Calcium Responses to Thyrotropin-Releasing Hormone, Gonadotropin-Releasing Hormone and Somatostatin in Phospholipase Cβ3 Knockout MiceRomoser V, Graves T, Wu D, Jiang H, Hinkle P. Calcium Responses to Thyrotropin-Releasing Hormone, Gonadotropin-Releasing Hormone and Somatostatin in Phospholipase Cβ3 Knockout Mice Endocrinology 2001, 15: 125-135. PMID: 11145744, DOI: 10.1210/mend.15.1.0588.
Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathwayWong H, Mao J, Nguyen J, Srinivas S, Zhang W, Liu B, Li L, Wu D, Zheng J. Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway Nature Structural & Molecular Biology 2000, 7: 1178-1184. PMID: 11101902, PMCID: PMC4381838, DOI: 10.1038/82047.
Roles of phospholipid signaling in chemoattractant-induced responsesWu D, Huang C, Jiang H. Roles of phospholipid signaling in chemoattractant-induced responses Journal Of Cell Science 2000, 113: 2935-2940. PMID: 10934033, DOI: 10.1242/jcs.113.17.2935.
Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal TransductionLi Z, Jiang H, Xie W, Zhang Z, Smrcka A, Wu D. Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction Science 2000, 287: 1046-1049. PMID: 10669417, DOI: 10.1126/science.287.5455.1046.
Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription*Wu D, Strovel E, Sussman D. Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription* Journal Of Biological Chemistry 2000, 275: 2399-2403. PMID: 10644691, DOI: 10.1074/jbc.275.4.2399.
Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Wu D, Simon M, Kano M. Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4 2000, 124: 31-48. PMID: 10943115, DOI: 10.1016/s0079-6123(00)24006-5.
Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells.Li L, Yuan H, Xie W, Mao J, Caruso A, Sussman D, Wu D. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. Journal Of Biological Chemistry 1999, 274: 33178. DOI: 10.1016/s0021-9258(17)46631-2.
Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation*Yuan H, Mao J, Li L, Wu D. Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation* Journal Of Biological Chemistry 1999, 274: 30419-30423. PMID: 10521419, DOI: 10.1074/jbc.274.43.30419.
Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioidsXie W, Samoriski G, McLaughlin J, Romoser V, Smrcka A, Hinkle P, Bidlack J, Gross R, Jiang H, Wu D. Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 10385-10390. PMID: 10468617, PMCID: PMC17897, DOI: 10.1073/pnas.96.18.10385.
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1Li L, Yuan H, Weaver C, Mao J, Farr G, Sussman D, Jonkers J, Kimelman D, Wu D. Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1 The EMBO Journal 1999, 18: 4233-4240. PMID: 10428961, PMCID: PMC1171499, DOI: 10.1093/emboj/18.15.4233.
Dishevelled Proteins Lead to Two Signaling Pathways REGULATION OF LEF-1 AND c-Jun N-TERMINAL KINASE IN MAMMALIAN CELLS*Li L, Yuan H, Xie W, Mao J, Caruso A, McMahon A, Sussman D, Wu D. Dishevelled Proteins Lead to Two Signaling Pathways REGULATION OF LEF-1 AND c-Jun N-TERMINAL KINASE IN MAMMALIAN CELLS* Journal Of Biological Chemistry 1999, 274: 129-134. PMID: 9867820, DOI: 10.1074/jbc.274.1.129.
Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellumKano M, Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Simon M, Wu D. Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 15724-15729. PMID: 9861037, PMCID: PMC28111, DOI: 10.1073/pnas.95.26.15724.
Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13Mao J, Yuan H, Xie W, Wu D. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13 Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 12973-12976. PMID: 9789025, PMCID: PMC23675, DOI: 10.1073/pnas.95.22.12973.
Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13Mao J, Xie W, Yuan H, Simon M, Mano H, Wu D. Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13 The EMBO Journal 1998, 17: 5638-5646. PMID: 9755164, PMCID: PMC1170892, DOI: 10.1093/emboj/17.19.5638.
Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors*Mao J, Yuan H, Xie W, Simon M, Wu D. Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors* Journal Of Biological Chemistry 1998, 273: 27118-27123. PMID: 9765229, DOI: 10.1074/jbc.273.42.27118.
Identification of a Structural Element in Phospholipase C β2 That Interacts with G Protein βγ Subunits*Sankaran B, Osterhout J, Wu D, Smrcka A. Identification of a Structural Element in Phospholipase C β2 That Interacts with G Protein βγ Subunits* Journal Of Biological Chemistry 1998, 273: 7148-7154. PMID: 9507029, DOI: 10.1074/jbc.273.12.7148.
Two Basic Amino Acids in the Second Inner Loop of the Interleukin-8 Receptor Are Essential for Gα16 Coupling*Xie W, Jiang H, Wu Y, Wu D. Two Basic Amino Acids in the Second Inner Loop of the Interleukin-8 Receptor Are Essential for Gα16 Coupling* Journal Of Biological Chemistry 1997, 272: 24948-24951. PMID: 9312098, DOI: 10.1074/jbc.272.40.24948.
Roles of phospholipase C β2 in chemoattractant-elicited responsesJiang H, Kuang Y, Wu Y, Xie W, Simon M, Wu D. Roles of phospholipase C β2 in chemoattractant-elicited responses Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 7971-7975. PMID: 9223297, PMCID: PMC21539, DOI: 10.1073/pnas.94.15.7971.
α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled ReceptorKrasnoperov V, Bittner M, Beavis R, Kuang Y, Salnikow K, Chepurny O, Little A, Plotnikov A, Wu D, Holz R, Petrenko A. α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor Neuron 1997, 18: 925-937. PMID: 9208860, DOI: 10.1016/s0896-6273(00)80332-3.
302 Multiple climbing fiber innervation of cerebellar purkinje cells in mutant mice lacking the phospholipase C-β4 (PLC β4)Kano M, Hashimoto K, Watanabe M, Kurihara H, Inoue Y, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Simon M, Wu D. 302 Multiple climbing fiber innervation of cerebellar purkinje cells in mutant mice lacking the phospholipase C-β4 (PLC β4) Neuroscience Research 1997, 28: s53. DOI: 10.1016/s0168-0102(97)90133-4.
Phospholipase C β4 is involved in modulating the visual response in miceJiang H, Lyubarsky A, Dodd R, Vardi N, Pugh E, Baylor D, Simon M, Wu D. Phospholipase C β4 is involved in modulating the visual response in mice Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14598-14601. PMID: 8962098, PMCID: PMC26179, DOI: 10.1073/pnas.93.25.14598.
Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors*Jiang H, Kuang Y, Wu Y, Smrcka A, Simon M, Wu D. Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors* Journal Of Biological Chemistry 1996, 271: 13430-13434. PMID: 8662841, DOI: 10.1074/jbc.271.23.13430.
Identification of a phospholipase C beta2 region that interacts with Gbeta-gamma.Kuang Y, Wu Y, Smrcka A, Jiang H, Wu D. Identification of a phospholipase C beta2 region that interacts with Gbeta-gamma. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 2964-2968. PMID: 8610151, PMCID: PMC39743, DOI: 10.1073/pnas.93.7.2964.
Selective G Protein Coupling by C-C Chemokine Receptors (∗)Kuang Y, Wu Y, Jiang H, Wu D. Selective G Protein Coupling by C-C Chemokine Receptors (∗) Journal Of Biological Chemistry 1996, 271: 3975-3978. PMID: 8626727, DOI: 10.1074/jbc.271.8.3975.
Selective Coupling of β2-Adrenergic Receptor to Hematopoietic-specific G Proteins (∗)Wu D, Kuang Y, Wu Y, Jiang H. Selective Coupling of β2-Adrenergic Receptor to Hematopoietic-specific G Proteins (∗) Journal Of Biological Chemistry 1995, 270: 16008-16010. PMID: 7608160, DOI: 10.1074/jbc.270.27.16008.
Different α1-Adrenergic Receptor Sequences Required for Activating Different Gα Subunits of Gq Class of G Proteins (∗)Wu D, Jiang H, Simon M. Different α1-Adrenergic Receptor Sequences Required for Activating Different Gα Subunits of Gq Class of G Proteins (∗) Journal Of Biological Chemistry 1995, 270: 9828-9832. PMID: 7730363, DOI: 10.1074/jbc.270.17.9828.
Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins.Jiang H, Wu D, Simon M. Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins. Journal Of Biological Chemistry 1994, 269: 7593-7596. PMID: 8125982, DOI: 10.1016/s0021-9258(17)37328-3.
The transforming activity of activated Gα12Jiang H, Wu D, Simon M. The transforming activity of activated Gα12 FEBS Letters 1993, 330: 319-322. PMID: 8397105, DOI: 10.1016/0014-5793(93)80896-3.
G Protein-Coupled Signal Transduction Pathways for Interleukin-8Wu D, LaRosa G, Simon M. G Protein-Coupled Signal Transduction Pathways for Interleukin-8 Science 1993, 261: 101-103. PMID: 8316840, DOI: 10.1126/science.8316840.
Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins.Wu D, Jiang H, Katz A, Simon M. Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins. Journal Of Biological Chemistry 1993, 268: 3704-3709. PMID: 8381437, DOI: 10.1016/s0021-9258(18)53750-9.
Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase CKatz A, Wu D, Simon M. Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C Nature 1992, 360: 686-689. PMID: 1465134, DOI: 10.1038/360686a0.
Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.Wu D, Katz A, Lee C, Simon M. Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. Journal Of Biological Chemistry 1992, 267: 25798-25802. PMID: 1334487, DOI: 10.1016/s0021-9258(18)35680-1.
Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.Wu D, Lee C, Rhee S, Simon M. Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells. Journal Of Biological Chemistry 1992, 267: 1811-1817. PMID: 1309799, DOI: 10.1016/s0021-9258(18)46018-8.
Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.Gutowski S, Smrcka A, Nowak L, Wu D, Simon M, Sternweis P. Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones. Journal Of Biological Chemistry 1991, 266: 20519-20524. PMID: 1657928, DOI: 10.1016/s0021-9258(18)54955-3.

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Dianqing (Dan) Wu, PhD

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