Clare Flannery, MD

• Christian Pettker
• Emre Seli
• Shannon Whirledge
• Yingqun Huang

Diabetes Mellitus, Type 2; Endometrial Hyperplasia; Obesity; Placenta; Endometrial Neoplasms; Perimenopause

• Estradiol cycling drives female obesogenic adipocyte hyperplasiadel M. Saavedra-Peña R, Taylor N, Flannery C, Rodeheffer M. Estradiol cycling drives female obesogenic adipocyte hyperplasia. Cell Reports 2023, 42: 112390. PMID: 37053070, PMCID: PMC10567995, DOI: 10.1016/j.celrep.2023.112390.
• Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice.Saleh FL, Joshi AA, Tal A, Xu P, Hens J, Wong SL, Flannery C. Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice. Journal Of Endocrinology 2022, 254: 121-135. PMID: 35904489, PMCID: PMC9837806, DOI: 10.1530/joe-21-0447.
• LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTHGlenn T, Silva E, Suarez P, Flannery C, Whirledge S. LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH. Fertility And Sterility 2021, 116: e419-e420. DOI: 10.1016/j.fertnstert.2021.07.1121.
• Identification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed EstradiolKelly K, Huang J, Joshi A, Tal A, Wong S, Flannery C. Identification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed Estradiol. Journal Of The Endocrine Society 2021, 5: a750-a751. DOI: 10.1210/jendso/bvab048.1526.
• Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age MiceHuang J, Xiao E, Tal A, Kelly K, Kim J, Whirledge S, Flannery C. Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice. Journal Of The Endocrine Society 2021, 5: a752-a752. DOI: 10.1210/jendso/bvab048.1529.
• OR20-07 Placentas from Obese Women Are Resistant to the Effect of Insulin on Triglyceride Content Ex VivoAnam A, Cooke K, O’Bryan J, Vijayakumar P, Vatner D, Flannery C. OR20-07 Placentas from Obese Women Are Resistant to the Effect of Insulin on Triglyceride Content Ex Vivo. Journal Of The Endocrine Society 2020, 4: or20-07. PMCID: PMC7208041, DOI: 10.1210/jendso/bvaa046.1911.
• SAT-LB041 Insulin and IGF-2 Equally Regulate Placental Triglyceride ContentAnam A, Cooke K, O'Bryan J, Flannery C. SAT-LB041 Insulin and IGF-2 Equally Regulate Placental Triglyceride Content. Journal Of The Endocrine Society 2019, 3: sat-lb041. PMCID: PMC6552031, DOI: 10.1210/js.2019-sat-lb041.
• SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor TransactivationSmalls B, Millard C, Kisanga E, Flannery C, Al-Hendy A, Whirledge S. SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation. Journal Of The Endocrine Society 2019, 3: sun-019. PMCID: PMC6553416, DOI: 10.1210/js.2019-sun-019.
• Postmenopausal Women with Endometrial Cancer Have Greater Metabolic Dysfunction and Higher BMI than Women with Benign EndometriumCOOKE K, DUN E, ANAM A, FLANNERY C. Postmenopausal Women with Endometrial Cancer Have Greater Metabolic Dysfunction and Higher BMI than Women with Benign Endometrium. Diabetes 2018, 67 DOI: 10.2337/db18-302-lb.
• Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of PubertySALEH F, TAYLOR H, FLANNERY C. Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty. Diabetes 2018, 67 DOI: 10.2337/db18-245-lb.
• Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and managementAraque KA, Kadayakkara DK, Gigauri N, Sheehan D, Majumdar S, Buller G, Flannery CA. Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management. BMJ Open Quality 2018, 7: e000120. PMID: 29756070, PMCID: PMC5942454, DOI: 10.1136/bmjoq-2017-000120.
• Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.
• Ovarian Morphology by Transabdominal Ultrasound Correlates With Reproductive and Metabolic Disturbance in Adolescents With PCOSRackow BW, Brink H, Hammers L, Flannery CA, Lujan ME, Burgert TS. Ovarian Morphology by Transabdominal Ultrasound Correlates With Reproductive and Metabolic Disturbance in Adolescents With PCOS. Journal Of Adolescent Health 2017, 62: 288-293. PMID: 29217212, PMCID: PMC9843701, DOI: 10.1016/j.jadohealth.2017.09.005.
• Time course analysis of RNA quality in placenta preserved by RNAlater or flash freezingMartin NM, Cooke KM, Radford CC, Perley LE, Silasi M, Flannery CA. Time course analysis of RNA quality in placenta preserved by RNAlater or flash freezing. American Journal Of Reproductive Immunology 2017, 77 PMID: 28138995, PMCID: PMC5397349, DOI: 10.1111/aji.12637.
• Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine EndometriumFlannery CA, Fleming AG, Choe GH, Naqvi H, Zhang M, Sharma A, Taylor HS. Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium. Endocrinology 2016, 157: 3699-3708. PMID: 27267714, PMCID: PMC5045514, DOI: 10.1210/en.2016-1233.
• Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in AdenocarcinomaFlannery CA, Saleh FL, Choe GH, Selen DJ, Kodaman PH, Kliman HJ, Wood TL, Taylor HS. Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 2883-2891. PMID: 27088794, PMCID: PMC4929835, DOI: 10.1210/jc.2016-1795.
• Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor IsoformsFlannery CA, Rowzee AM, Choe GH, Saleh FL, Radford CC, Taylor HS, Wood TL. Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms. Endocrinology 2016, 157: 1702-1708. PMID: 26862994, PMCID: PMC4816738, DOI: 10.1210/en.2015-1698.
• H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosisGhazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Molecular Medicine 2015, 7: 996-1003. PMID: 26089099, PMCID: PMC4551339, DOI: 10.15252/emmm.201505245.
• mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic EndometriumKaralok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.
• The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cellsGao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, Shulman GI, Huang Y. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Research 2014, 42: 13799-13811. PMID: 25399420, PMCID: PMC4267628, DOI: 10.1093/nar/gku1160.
• Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes‐Associated Uteroplacental InsufficiencyHan CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM. Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes‐Associated Uteroplacental Insufficiency. American Journal Of Reproductive Immunology 2014, 73: 362-371. PMID: 25394884, PMCID: PMC4356646, DOI: 10.1111/aji.12339.
• T-cell intracellular antigen (TIA-1) modulates the expression of immune factors in endometrial cells and may contribute to endometriosisDuke C, Karalok H, Choe G, Flannery C, Kallen C, Seli E. T-cell intracellular antigen (TIA-1) modulates the expression of immune factors in endometrial cells and may contribute to endometriosis. Fertility And Sterility 2014, 102: e5. DOI: 10.1016/j.fertnstert.2014.07.024.
• The noncoding RNAs H19 and let-7 alter IGF signaling and stromal cell growth in the endometrium of women with endometriosisGhazal S, McKinnon B, Zhou J, Mueller M, Flannery C, Huang Y, Taylor H. The noncoding RNAs H19 and let-7 alter IGF signaling and stromal cell growth in the endometrium of women with endometriosis. Fertility And Sterility 2014, 102: e5-e6. DOI: 10.1016/j.fertnstert.2014.07.025.
• Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the ElderlyFlannery C, Dufour S, Rabøl R, Shulman GI, Petersen KF. Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly. Diabetes 2012, 61: 2711-2717. PMID: 22829450, PMCID: PMC3478531, DOI: 10.2337/db12-0206.
• Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMIFlannery CA, Rackow B, Cong X, Duran E, Selen DJ, Burgert TS. Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI. Pediatric Diabetes 2012, 14: 42-49. PMID: 22925367, PMCID: PMC4864958, DOI: 10.1111/j.1399-5448.2012.00902.x.
• Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individualsRabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 13705-13709. PMID: 21808028, PMCID: PMC3158147, DOI: 10.1073/pnas.1110105108.
• Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistanceWeismann D, Erion DM, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao JJ, Flannery C, Birkenfeld AL, May T, Kahn M, Zhang D, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Shulman GI, Samuel VT. Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance. Diabetologia 2010, 54: 935-944. PMID: 21190014, PMCID: PMC4061906, DOI: 10.1007/s00125-010-1984-5.
• Understanding the presentation of polycystic ovary syndrome (PCOS) in the adolescent population: results from a multispecialty adolescent PCOS programRackow B, Duran E, Flannery C, Burgert T. Understanding the presentation of polycystic ovary syndrome (PCOS) in the adolescent population: results from a multispecialty adolescent PCOS program. Fertility And Sterility 2010, 94: s71. DOI: 10.1016/j.fertnstert.2010.07.275.
• Impaired Glucose Tolerance in Adolescents with Polycystic Ovarian SyndromeRackow B, Thomas M, Duran E, Flannery C, Burgert T. Impaired Glucose Tolerance in Adolescents with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2010, 23: e62-e63. DOI: 10.1016/j.jpag.2010.01.010.
• Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding ProteinErion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI. Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein. Cell Metabolism 2009, 10: 499-506. PMID: 19945407, PMCID: PMC2799933, DOI: 10.1016/j.cmet.2009.10.007.
• Micelle-Induced Changes in the Solvation of Carbocations: Effect of Sodium Dodecyl Sulfate Micelles on the Enantiomer-Specific Oxygen Exchange Reactions of 1-Phenyl-1-ethanol and 1-Phenyl-1-butanolMerritt M, Chang I, Flannery C, Hsieh S, Lee K, Yung J. Micelle-Induced Changes in the Solvation of Carbocations: Effect of Sodium Dodecyl Sulfate Micelles on the Enantiomer-Specific Oxygen Exchange Reactions of 1-Phenyl-1-ethanol and 1-Phenyl-1-butanol. Journal Of The American Chemical Society 1995, 117: 9791-9799. DOI: 10.1021/ja00144a002.
• Enantiomer-Specific Oxygen Exchange Reactions. 2. Acid-Catalyzed Water Exchange with 1-Phenyl-1-alkanolsMerritt M, Anderson D, Basu K, Chang I, Cheon H, Mukundan N, Flannery C, Kim A, Vaishampayan A, Yens D. Enantiomer-Specific Oxygen Exchange Reactions. 2. Acid-Catalyzed Water Exchange with 1-Phenyl-1-alkanols. Journal Of The American Chemical Society 1994, 116: 5551-5559. DOI: 10.1021/ja00092a005.