Research & Publications
Dr. Fredericks’ research focuses on preclinical Alzheimer’s disease and on less common Alzheimer’s variants, using advanced imaging tools to better understand how Alzheimer’s disease progresses through functional networks in the brain.
Extensive Research Description
Specific projects we are currently pursuing include:
1) Using functional MRI and amyloid and tau PET to characterize how tau protein spreads in less common Alzheimer's variants such as posterior cortical atrophy and logopenic aphasia, and how tau spread relates to changes in functional network connectivity and how participants perform on neuropsychological tasks.
2) Using high-resolution structural and functional MRI to define the role of subcortical structures, such as certain brainstem and thalamic nuclei, in functional networks in Alzheimer's disease (including less common variants).
3) Developing paradigms that incorporate eye-tracking and functional MRI to understand how patients with posterior cortical atrophy process visual information.
Alzheimer Disease; Magnetic Resonance Imaging; Neuroimaging; Functional Neuroimaging; Positron Emission Tomography Computed Tomography