Bao-Zhu Yang, PhD

• Christopher van Dyck
• Edward Perry
• Hang Zhou
• Hongyu Zhao
• Irina Esterlis
• Joel Gelernter
• Kelly Cosgrove

Alcoholism; Behavior and Behavior Mechanisms; Mental Disorders; Depression; Epidemiology; Stress Disorders, Post-Traumatic; Models, Statistical; Psychiatry and Psychology

• F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISKZhou H, Yang B, Kranzler H, Gelernter J. F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK. European Neuropsychopharmacology 2023, 75: s274. DOI: 10.1016/j.euroneuro.2023.08.480.
• Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorderHe L, Yang B, Ma Y, Wen L, Liu F, Zhang X, Liu T. Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder. Frontiers In Cellular And Infection Microbiology 2023, 13: 1103919. PMID: 36909722, PMCID: PMC9996337, DOI: 10.3389/fcimb.2023.1103919.
• Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)Ma YJ, Wang YY, Liu MQ, Fang T, Wei ZR, Chen SB, Tan H, Nunez YZ, Zhang XJ, Hao W, Malison RT, Kranzler HR, Gelernter J, Liu TQ, Yang BZ. Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug And Alcohol Dependence 2021, 229: 109047. PMID: 34710713, DOI: 10.1016/j.drugalcdep.2021.109047.
• Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preferenceYang C, Fu X, Hao W, Xiang X, Liu T, Yang B, Zhang X. Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference. Addiction Biology 2020, 26: e12975. PMID: 33094505, DOI: 10.1111/adb.12975.
• GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individualsYang BZ, Balodis IM, Kober H, Worhunsky PD, Lacadie CM, Gelernter J, Potenza MN. GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals. Addictive Behaviors 2020, 114: 106695. PMID: 33153773, PMCID: PMC8299472, DOI: 10.1016/j.addbeh.2020.106695.
• Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese VersionYang BZ, Wang LJ, Huang MC, Wang SC, Tsai MC, Huang YC, Nuñez YZ, Ng MH, Kranzler HR, Gelernter J, Chen CK. Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version. Complex Psychiatry 2020, 6: 62-67. PMID: 34882761, PMCID: PMC7923924, DOI: 10.1159/000511606.
• Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated childrende Araújo CM, Hudziak J, Crocetti D, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Yang BZ, Mostofsky S, Jackowski A, Lee RS, Gelernter J, Kaufman J. Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children. Psychiatry Research Neuroimaging 2020, 298: 111058. PMID: 32120304, DOI: 10.1016/j.pscychresns.2020.111058.
• Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African AmericansYang BZ, Zhou H, Cheng Z, Kranzler HR, Gelernter J. Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans. Scientific Reports 2019, 9: 18070. PMID: 31792237, PMCID: PMC6889277, DOI: 10.1038/s41598-019-53560-0.
• Genome‐wide scan identifies opioid overdose risk locus close to MCOLN1Cheng Z, Yang B, Zhou H, Nunez Y, Kranzler HR, Gelernter J. Genome‐wide scan identifies opioid overdose risk locus close to MCOLN1. Addiction Biology 2019, 25: e12811. PMID: 31362332, PMCID: PMC7485539, DOI: 10.1111/adb.12811.
• M31 GENOME-WIDE ASSOCIATION STUDY OF COMORBID ALCOHOL DEPENDENCE AND MAJOR DEPRESSIONZhou H, Polimanti R, Yang B, Wang Q, Han S, Sherva R, Nunez Y, Zhao H, Farrer L, Kranzler H, Gelernter J. M31 GENOME-WIDE ASSOCIATION STUDY OF COMORBID ALCOHOL DEPENDENCE AND MAJOR DEPRESSION. European Neuropsychopharmacology 2019, 29: s971. DOI: 10.1016/j.euroneuro.2017.08.338.
• F135GENOMEWIDE SEX-BY-SNP INTERACTION SCAN IDENTIFIES ADGRV1 FOR THE SEX DIFFERENCES OF OPIOID DEPENDENCE IN AFRICAN AMERICAN AND SUPPORTING EVIDENCE IN RELATIONS WITH TREATMENT SIDE EFFECTS IN THE ASIAN POPULATIONYang B, Zhou H, Cheng Z, Liu T, Chung R, Kranzler H, Wang S, Farrer L, Liu Y, Gelernter J. F135GENOMEWIDE SEX-BY-SNP INTERACTION SCAN IDENTIFIES ADGRV1 FOR THE SEX DIFFERENCES OF OPIOID DEPENDENCE IN AFRICAN AMERICAN AND SUPPORTING EVIDENCE IN RELATIONS WITH TREATMENT SIDE EFFECTS IN THE ASIAN POPULATION. European Neuropsychopharmacology 2019, 29: s1183-s1184. DOI: 10.1016/j.euroneuro.2018.08.215.
• GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and networkXiang B, Yang B, Zhou H, Kranzler H, Gelernter J. GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 180: 3-11. PMID: 30488612, PMCID: PMC6918694, DOI: 10.1002/ajmg.b.32692.
• Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major DepressionZhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry 2017, 74: 1234-1241. PMID: 29071344, PMCID: PMC6331050, DOI: 10.1001/jamapsychiatry.2017.3275.
• GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social DrinkersYang B, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clinical And Experimental Research 2017, 41: 2025-2032. PMID: 29131352, PMCID: PMC5764175, DOI: 10.1111/acer.13516.
• Sex‐specific linkage scans in opioid dependenceYang B, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex‐specific linkage scans in opioid dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 261-268. PMID: 27762075, PMCID: PMC5695218, DOI: 10.1002/ajmg.b.32507.
• The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorderJensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Translational Psychiatry 2014, 4: e353-e353. PMID: 24473444, PMCID: PMC3905232, DOI: 10.1038/tp.2013.122.
• Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular SmokingStephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen L, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang B, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng Y, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi M, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin M, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA. Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking. Genetic Epidemiology 2013, 37: 846-859. PMID: 24186853, PMCID: PMC3947535, DOI: 10.1002/gepi.21760.
• GABRA2 Genotype, Impulsivity, and Body MassBauer LO, Yang B, Houston RJ, Kranzler HR, Gelernter J. GABRA2 Genotype, Impulsivity, and Body Mass. American Journal On Addictions 2012, 21: 404-410. PMID: 22882390, PMCID: PMC3773931, DOI: 10.1111/j.1521-0391.2012.00252.x.
• Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substancesYang B, Han S, Kranzler HR, Farrer LA, Elston RC, Gelernter J. Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 361-369. PMID: 22354695, PMCID: PMC3920832, DOI: 10.1002/ajmg.b.32037.
• GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African AmericansIttiwut C, Yang B, Kranzler HR, Anton RF, Hirunsatit R, Weiss RD, Covault J, Farrer LA, Gelernter J. GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African Americans. Alcohol Clinical And Experimental Research 2011, 36: 588-593. PMID: 21919924, PMCID: PMC3250564, DOI: 10.1111/j.1530-0277.2011.01637.x.
• Association of CHRNA4 polymorphisms with smoking behavior in two populationsHan S, Yang B, Kranzler HR, Oslin D, Anton R, Gelernter J. Association of CHRNA4 polymorphisms with smoking behavior in two populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 421-429. PMID: 21445957, PMCID: PMC3742073, DOI: 10.1002/ajmg.b.31177.
• Variation in NGFB is associated with primary affective disorders in womenCui D, Zhang H, Yang B, Listman JB, Li D, Price LH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. Variation in NGFB is associated with primary affective disorders in women. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 401-412. PMID: 21294249, PMCID: PMC3108453, DOI: 10.1002/ajmg.b.31175.
• Corticotrophin-Releasing Hormone Type 1 Receptor Gene ( CRHR1 ) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury PatientsAmstadter A, Nugent N, Yang B, Miller A, Siburian R, Moorjani P, Haddad S, Basu A, Fagerness J, Saxe G, Smoller J, Koenen K. Corticotrophin-Releasing Hormone Type 1 Receptor Gene ( CRHR1 ) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients. Disease Markers 2011, 30: 89-99. DOI: 10.1155/2011/928497.
• A genomewide ordered-subset linkage analysis for alcohol dependence in African-AmericansHan S, Yang B, Kranzler H, Gelernter J. A genomewide ordered-subset linkage analysis for alcohol dependence in African-Americans. Genome Biology 2010, 11: o6. PMCID: PMC3026233, DOI: 10.1186/gb-2010-11-s1-o6.
• Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking BehaviorHan S, Gelernter J, Luo X, Yang BZ. Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior. Biological Psychiatry 2010, 67: 12-19. PMID: 19819424, PMCID: PMC2975396, DOI: 10.1016/j.biopsych.2009.08.028.
• Measurement of admixture proportions and description of admixture structure in different U.S. populationsHalder I, Yang B, Kranzler HR, Stein MB, Shriver MD, Gelernter J. Measurement of admixture proportions and description of admixture structure in different U.S. populations. Human Mutation 2009, 30: 1299-1309. PMID: 19572378, PMCID: PMC2867064, DOI: 10.1002/humu.21045.
• Is the Tail-Strength Measure More Powerful in Tests of Genetic Association?Han S, Ma L, Li D, Yang BZ. Is the Tail-Strength Measure More Powerful in Tests of Genetic Association? American Journal Of Human Genetics 2009, 84: 295-298. PMID: 19215734, PMCID: PMC2668021, DOI: 10.1016/j.ajhg.2009.01.015.
• Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug DependenceYang B, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence. Alcohol Clinical And Experimental Research 2008, 32: 2117-2127. PMID: 18828801, PMCID: PMC2975565, DOI: 10.1111/j.1530-0277.2008.00800.x.
• Single nucleotide polymorphisms of ANKK1 and CHRNA4: Influence on nicotinic acetylcholine receptor availability in nonsmokers measured using [123I]5-IA-85380 SPECTBatis J, Yang B, Cosgrove K, Bois F, Esterlis I, Stiklus S, Kloczynski T, Perry E, Seibyl J, Tamagnan G, Van Dyck C, Gelernter J, Staley J. Single nucleotide polymorphisms of ANKK1 and CHRNA4: Influence on nicotinic acetylcholine receptor availability in nonsmokers measured using [123I]5-IA-85380 SPECT. NeuroImage 2008, 41: t174. DOI: 10.1016/j.neuroimage.2008.04.141.
• Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samplesYang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samples. Human Molecular Genetics 2007, 16: 2844-2853. PMID: 17761687, DOI: 10.1093/hmg/ddm240.
• The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence riskZhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Molecular Psychiatry 2007, 13: 531-543. PMID: 17622222, PMCID: PMC3163084, DOI: 10.1038/sj.mp.4002035.
• Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependenceZhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Price LH, Southwick S, Yang B, Rasmussen A, Gelernter J. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 141B: 387-393. PMID: 16649215, PMCID: PMC2567822, DOI: 10.1002/ajmg.b.30332.
• Tumour necrosis factor α polymorphism (−1031T/C) is associated with age of onset of schizophreniaZhang X, Haile C, Tan Y, Zuo L, Yang B, Cao L, Zhou D. Tumour necrosis factor α polymorphism (−1031T/C) is associated with age of onset of schizophrenia. Molecular Psychiatry 2005, 10: 897-899. PMID: 16027740, DOI: 10.1038/sj.mp.4001710.
• Practical population group assignment with selected informative markers: Characteristics and properties of Bayesian clustering via STRUCTUREYang B, Zhao H, Kranzler HR, Gelernter J. Practical population group assignment with selected informative markers: Characteristics and properties of Bayesian clustering via STRUCTURE. Genetic Epidemiology 2005, 28: 302-312. PMID: 15782414, DOI: 10.1002/gepi.20070.
• Social supports and serotonin transporter gene moderate depression in maltreated childrenKaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17316-17321. PMID: 15563601, PMCID: PMC534414, DOI: 10.1073/pnas.0404376101.
• Fingerprinting PCB patterns among Mohawk womenHWANG S, YANG B, FITZGERALD E, BUSH B, COOK K. Fingerprinting PCB patterns among Mohawk women. Journal Of Exposure Science & Environmental Epidemiology 2001, 11: 184-192. PMID: 11477516, DOI: 10.1038/sj.jea.7500159.
• Assessing Environmental Exposure to PCBs among Mohawks at Akwesasne through the Use of Geostatistical MethodsHwang S, Fitzgerald E, Cayo M, Yang B, Tarbell A, Jacobs A. Assessing Environmental Exposure to PCBs among Mohawks at Akwesasne through the Use of Geostatistical Methods. Environmental Research 1999, 80: s189-s199. PMID: 10092433, DOI: 10.1006/enrs.1998.3913.
• Local Fish Consumption and Serum PCB Concentrations among Mohawk Men at AkwesasneFitzgerald E, Deres D, Hwang S, Bush B, Yang B, Tarbell A, Jacobs A. Local Fish Consumption and Serum PCB Concentrations among Mohawk Men at Akwesasne. Environmental Research 1999, 80: s97-s103. PMID: 10092423, DOI: 10.1006/enrs.1998.3908.
• Statistical model for estimating measurement error in the congener-specific analysis of PCBs by gas chromatographyYang B, Zurbenko I, Hwang S. Statistical model for estimating measurement error in the congener-specific analysis of PCBs by gas chromatography. Chemometrics And Intelligent Laboratory Systems 1996, 34: 217-229. DOI: 10.1016/0169-7439(96)00030-5.