Featured Publications
Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors
Lin ZP, Ratner ES, Whicker ME, Lee Y, Sartorelli AC. Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors. Molecular Cancer Research 2014, 12: 381-393. PMID: 24413181, PMCID: PMC3962722, DOI: 10.1158/1541-7786.mcr-13-0480.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Ovarian EpithelialCarrier ProteinsCell Line, TumorDrug SynergismFemaleHumansNeoplasms, Glandular and EpithelialOvarian NeoplasmsPhthalazinesPiperazinesPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesPyridinesRecombination, GeneticRecombinational DNA RepairThiosemicarbazonesTopoisomerase InhibitorsTransfectionConceptsHomologous recombination repairEOC cellsCtIP phosphorylationRecombination repairDNA double-strand break resectionCyclin-dependent kinase activityTopoisomerase II inhibitor etoposidePhosphorylation of CtIPDouble-strand break resectionSmall molecule inhibitorsRPA32 phosphorylationBRCA1 interactionBRCA1 fociNbs1 complexMre11-Rad50Chk1 activationDSB resectionKinase activitySynthetic lethalityRAD51 fociOvarian cancer cellsInhibitor etoposideCell cycleRibonucleotide reductaseCtIP
2004
Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06
Zeng H, Lin ZP, Sartorelli AC. Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06. Biochemical Pharmacology 2004, 68: 911-921. PMID: 15294454, DOI: 10.1016/j.bcp.2004.06.004.Peer-Reviewed Original Research
2002
Comparative study of the importance of multidrug resistance-associated protein 1 and P-glycoprotein to drug sensitivity in immortalized mouse embryonic fibroblasts.
Lin ZP, Johnson DR, Finch RA, Belinsky MG, Kruh GD, Sartorelli AC. Comparative study of the importance of multidrug resistance-associated protein 1 and P-glycoprotein to drug sensitivity in immortalized mouse embryonic fibroblasts. Molecular Cancer Therapeutics 2002, 1: 1105-14. PMID: 12481434.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnticarcinogenic AgentsAntineoplastic AgentsAntineoplastic Agents, PhytogenicATP Binding Cassette Transporter, Subfamily B, Member 1Biological TransportBlotting, WesternCell SurvivalCells, CulturedChemokines, CCDose-Response Relationship, DrugEtoposideFibroblastsFluoresceinsInhibitory Concentration 50MiceMice, KnockoutPrecipitin TestsReverse Transcriptase Polymerase Chain ReactionRNATime FactorsTransfectionTumor Cells, CulturedVincristineConceptsMultidrug resistance-associated protein 1P-glycoproteinWT fibroblastsDKO fibroblastsCalcein accumulationDrug sensitivityProtein 1Unrelated anticancer agentsAnticancer agentsImmortalized mouse embryonic fibroblastsWestern blot analysisKnockout miceCompensatory mechanismsAccumulation assaysMouse embryonic fibroblastsCompensatory changesEmbryonic fibroblastsMRP1Drug substratesBlot analysisCell viabilityMajor determinantFamily membersFibroblastsFibroblast lines