2025
Advancing the Evaluation and Management of CDH1-Associated Gastric Cancer.
Lerner B, Gupta S, Burke C, Kupfer S, Katona B, Grady W, Samadder J, Yurgelun M, Kelly K, Moreno Prats M, Joseph N, Idos G, Swanson B, Kieber-Emmons A, Weiss J, Llor X. Advancing the Evaluation and Management of CDH1-Associated Gastric Cancer. Journal Of The National Comprehensive Cancer Network 2025, 23 PMID: 40203872, DOI: 10.6004/jnccn.2025.7006.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDCadherinsCarcinoma, Signet Ring CellCdh1 ProteinsGastrectomyGenetic Predisposition to DiseaseGerm-Line MutationHumansStomach NeoplasmsConceptsSignet ring cell carcinomaPathogenic variant carriersGastric cancerEndoscopic surveillanceTotal gastrectomyVariant carriersGermline pathogenic variant carriersBenefits of gastrectomyCDH1 pathogenic variantsRisk of gastric cancerAdvanced gastric cancerProphylactic total gastrectomyPathogenic germline variantsFollow-up periodCumulative lifetime riskEvidence-based recommendationsUpper endoscopyCell carcinomaGlobal health concernDetected signet ring cell carcinomasGermline variantsPathogenic variantsGastrectomyGastrectomy specimensAdvanced cancer
2011
Validation Microsatellite Path Score in a Population-Based Cohort of Patients With Colorectal Cancer
Bessa X, Alenda C, Paya A, Álvarez C, Iglesias M, Seoane A, Dedeu JM, Abulí A, Ilzarbe L, Navarro G, Pellise M, Balaguer F, Castellvi-Bel S, LLor X, Castells A, Jover R, Andreu M. Validation Microsatellite Path Score in a Population-Based Cohort of Patients With Colorectal Cancer. Journal Of Clinical Oncology 2011, 29: 3374-3380. PMID: 21788563, DOI: 10.1200/jco.2010.34.3947.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdenocarcinoma, MucinousAgedCarcinoma, MedullaryCarcinoma, Signet Ring CellCohort StudiesColorectal NeoplasmsDNA Mismatch RepairFemaleFollow-Up StudiesGerm-Line MutationHeterozygoteHumansMaleMicrosatellite InstabilityMutL Protein Homolog 1MutS Homolog 2 ProteinNuclear ProteinsPrognosisProspective StudiesProto-Oncogene Proteins B-rafSensitivity and SpecificitySpainConceptsPositive predictive valuePathologic featuresColorectal cancerLynch syndromeGermline MSH2 mutationMLH1/MSH2Cohort of patientsColorectal cancer populationSelection of patientsPopulation-based cohortBRAF mutation analysisMicrosatellite instability analysisHigher CRCGermline testingBethesda guidelinesTumor characteristicsPathological scoresTumor locationCancer populationMismatch repairMMR statusFamily historyMutation carriersPatientsMSH2 mutations
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