1992
Hydroxypropylcyclodextrins in parenteral use. II: Effects on transport and disposition of lipids in rabbit and humans
Irie T, Fukunaga K, Garwood M, Carpenter T, Pitha J, Pitha J. Hydroxypropylcyclodextrins in parenteral use. II: Effects on transport and disposition of lipids in rabbit and humans. Journal Of Pharmaceutical Sciences 1992, 81: 524-528. PMID: 1522488, DOI: 10.1002/jps.2600810610.Peer-Reviewed Original ResearchConceptsTotal cholesterolHyperlipidemic Watanabe rabbitsOnly untoward effectSingle intravenous administrationProximal convoluted tubulesDisposition of lipidsIntravenous infusionHypervitaminosis ARepeated administrationThoracic aortaWatanabe rabbitsIntravenous administrationUntoward effectsAtherosclerotic lesionsSingle injectionConvoluted tubulesParenteral administrationParenteral useCholesterolAdministrationSlight reliefPatientsInfusionRabbitsHydroxypropyl-beta
1987
Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake
Carpenter T, Pettifor J, Russell R, Pitha J, Mobarhan S, Ossip M, Wainer S, Anast C. Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake. The Journal Of Pediatrics 1987, 111: 507-512. PMID: 3655980, DOI: 10.1016/s0022-3476(87)80109-9.Peer-Reviewed Original ResearchConceptsSimilar clinical featuresRetinyl ester levelsRetinol intakeTherapeutic trialsClinical featuresHypervitaminosis ADietary vitaminLiver spreadVitamin AMicrograms/Total vitaminInfusionRetinyl estersSame dietIntakeEventual deathVitaminEster levelsYounger brotherAgent 2SyndromeSymptomsYearsExcretionIntoxication