2015
Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats
Haley JM, Thackeray JT, Kolajova M, Thorn SL, DaSilva JN. Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats. Life Sciences 2015, 132: 101-107. PMID: 25934520, DOI: 10.1016/j.lfs.2015.03.024.Peer-Reviewed Original ResearchConceptsCardiac β-ARPositron emission tomographyΒ-ARHeart rateInsulin therapyDiabetes mellitusΒ-adrenoceptorsCV functionWestern blottingInsulin effectDuration of hyperglycemiaMyocardial β-adrenoceptorsΒ-AR expressionOnset of hyperglycemiaWeeks of hyperglycemiaCardiac β-adrenoceptorsΒ-AR subtypesReduced heart rateMyocardial β-ARsGlycemic therapyStreptozotocin ratsSerial echocardiographySTZ ratsGlycemic controlCardiovascular dysfunction
2005
Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders.
Yoshinaga K, Chow BJ, dekemp RA, Thorn S, Ruddy TD, Davies RA, DaSilva JN, Beanlands R. Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders. Current Pharmaceutical Design 2005, 11: 903-32. PMID: 15777243, DOI: 10.2174/1381612053381800.Peer-Reviewed Original ResearchConceptsVivo pharmacokinetic studyDrug deliveryMolecular probesCardiovascular diseaseEffect of therapyAccuracy of PETPET/CTNon-invasive imaging modalityEvaluation of drugsMolecular imagingPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyPotential of PETNon-invasive modalityMechanism of actionPharmacokinetic studyCardiac molecular imagingEarly drug developmentAdvantages of PETDrug therapyDisease progressionSerial evaluationDrug treatmentReceptor levels